Efficacy and safety of Poulvac E. coli vaccine in broiler chickens challenged with E. coli serotype O78 and an acute field isolate

Sadeghi, Mohammad Reza; Tavakkoli, Hadi; Golchin, Mehdi; Ghanbarpour, Reza; Amanollahi, Shiva

doi:10.1007/s00580-018-2784-4

Cited by 8 publications

(7 citation statements)

References 18 publications

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“…The vaccine is available as a freeze-dried powder (lyophilisate) and is given as a single-dose vaccine either by spray application with chicks from one day of age or by adding to the drinking water of chicks from five days of age. One important limitation of this vaccine that has been reported is limited protection against the diversity of APEC belonging to a multitude of different serotypes [ 439 , 440 ]. There is, therefore, a need to develop a vaccine against APEC that would provide broader spectrum protection against multiple serotypes.…”

Section: Pathogenic E Coli Of Importance To Animal...mentioning

confidence: 99%

The Diversity of Escherichia coli Pathotypes and Vaccination Strategies against This Versatile Bacterial Pathogen

2023

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Escherichia coli (E. coli) is a gram-negative bacillus and resident of the normal intestinal microbiota. However, some E. coli strains can cause diseases in humans, other mammals and birds ranging from intestinal infections, for example, diarrhea and dysentery, to extraintestinal infections, such as urinary tract infections, respiratory tract infections, meningitis, and sepsis. In terms of morbidity and mortality, pathogenic E. coli has a great impact on public health, with an economic cost of several billion dollars annually worldwide. Antibiotics are not usually used as first-line treatment for diarrheal illness caused by E. coli and in the case of bloody diarrhea, antibiotics are avoided due to the increased risk of hemolytic uremic syndrome. On the other hand, extraintestinal infections are treated with various antibiotics depending on the site of infection and susceptibility testing. Several alarming papers concerning the rising antibiotic resistance rates in E. coli strains have been published. The silent pandemic of multidrug-resistant bacteria including pathogenic E. coli that have become more difficult to treat favored prophylactic approaches such as E. coli vaccines. This review provides an overview of the pathogenesis of different pathotypes of E. coli, the virulence factors involved and updates on the major aspects of vaccine development against different E. coli pathotypes.

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Section: Pathogenic E Coli Of Importance To Animal...mentioning

confidence: 99%

The Diversity of Escherichia coli Pathotypes and Vaccination Strategies against This Versatile Bacterial Pathogen

2023

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“…The second live attenuated vaccine is developed by deleting aroA gene of E. coli-O78 strain (Poulvac1, E. coli, Zoetis), and is usually administered via coarse spray in day-old chicks. In a field trial, the Poulvac vaccine did not affect the weight gain in broiler chickens [54]. In experimental conditions, several studies have suggested its efficacy against homologous challenge in reducing colibacillosis-associated pathological lesions [54][55][56][57][58].…”

Section: Live and Live Attenuated Vaccinesmentioning

confidence: 99%

A systematic review and meta-analysis on the efficacy of vaccination against colibacillosis in broiler production

Paudel,

Apostolakos,

Vougat Ngom

et al. 2024

PLoS ONE

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Colibacillosis, a disease caused by Escherichia coli in broiler chickens has serious implications on food safety, security, and economic sustainability. Antibiotics are required for treating the disease, while vaccination and biosecurity are used for its prevention. This systematic review and meta-analysis, conducted under the COST Action CA18217—European Network for Optimization of Veterinary Antimicrobial Treatment (ENOVAT), aimed to assess the efficacy of E. coli vaccination in broiler production and provide evidence-based recommendations. A comprehensive search of bibliographic databases, including, PubMed, CAB Abstracts, Web of Science and Agricola, yielded 2,722 articles. Following a defined protocol, 39 studies were selected for data extraction. Most of the studies were experimental infection trials, with only three field studies identified, underscoring the need for more field-based research. The selected studies reported various types of vaccines, including killed (n = 5), subunit (n = 8), outer membrane vesicles/protein-based (n = 4), live/live-attenuated (n = 16), and CpG oligodeoxynucleotides (ODN) (n = 6) vaccines. The risk of bias assessment revealed that a significant proportion of studies reporting mortality (92.3%) or feed conversion ratio (94.8%) as outcomes, had “unclear” regarding bias. The meta-analysis, focused on live-attenuated and CpG ODN vaccines, demonstrated a significant trend favoring both vaccination types in reducing mortality. However, the review also highlighted the challenges in reproducing colibacillosis in experimental setups, due to considerable variation in challenge models involving different routes of infection, predisposing factors, and challenge doses. This highlights the need for standardizing the challenge model to facilitate comparisons between studies and ensure consistent evaluation of vaccine candidates. While progress has been made in the development of E. coli vaccines for broilers, further research is needed to address concerns such as limited heterologous protection, practicability for application, evaluation of efficacy in field conditions and adoption of novel approaches.

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“…Lozica et al [ 81 ] reported that an autonomous E. coli vaccine significantly reduced morbidity and mortality and increased egg production in poultry. Several studies showed that an E. coli vaccine, Poulvac® (Zoetis, Parsippany, NJ, USA) effectively worked against the avian pathogenic E. coli in poultry [ 82 , 83 , 84 , 85 , 86 , 87 ].…”

Section: A Review Of Current Research Studies On the Efficacy Of Bact...mentioning

confidence: 99%

A Comprehensive Review on Bacterial Vaccines Combating Antimicrobial Resistance in Poultry

Islam

Rahman

2023

Vaccines

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Bacterial vaccines have become a crucial tool in combating antimicrobial resistance (AMR) in poultry. The overuse and misuse of antibiotics in poultry farming have led to the development of AMR, which is a growing public health concern. Bacterial vaccines are alternative methods for controlling bacterial diseases in poultry, reducing the need for antibiotics and improving animal welfare. These vaccines come in different forms including live attenuated, killed, and recombinant vaccines, and they work by stimulating the immune system to produce a specific response to the target bacteria. There are many advantages to using bacterial vaccines in poultry, including reduced use of antibiotics, improved animal welfare, and increased profitability. However, there are also limitations such as vaccine efficacy and availability. The use of bacterial vaccines in poultry is regulated by various governmental bodies and there are economic considerations to be taken into account, including costs and return on investment. The future prospects for bacterial vaccines in poultry are promising, with advancements in genetic engineering and vaccine formulation, and they have the potential to improve the sustainability of the poultry industry. In conclusion, bacterial vaccines are essential in combating AMR in poultry and represent a crucial step towards a more sustainable and responsible approach to poultry farming.

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Efficacy and safety of Poulvac E. coli vaccine in broiler chickens challenged with E. coli serotype O78 and an acute field isolate

Cited by 8 publications

References 18 publications

The Diversity of Escherichia coli Pathotypes and Vaccination Strategies against This Versatile Bacterial Pathogen

The Diversity of Escherichia coli Pathotypes and Vaccination Strategies against This Versatile Bacterial Pathogen

A systematic review and meta-analysis on the efficacy of vaccination against colibacillosis in broiler production

A Comprehensive Review on Bacterial Vaccines Combating Antimicrobial Resistance in Poultry

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