Efficacy and safety of retinaldehyde 0.1% and 0.05% creams used to treat photoaged skin: A randomized double‐blind controlled trial

Kwon, Hyuck Sun; Lee, Ji Hae; Kim, Gyong Moon; Bae, Jung Min

doi:10.1111/jocd.12551

Cited by 20 publications

(28 citation statements)

References 14 publications

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“…10 As for melanin index, only the 0.1% retinaldehyde cream demonstrated a significant improvement. 10…”

Section: Retinaldehydementioning

confidence: 90%

“…evaluated the efficacy and safety of creams containing 0.05% and 0.1% retinaldehyde in a 3‐month randomized, double‐blind, controlled trial ( n = 40) . Subjects applied the treatment twice daily for 3 months . Wrinkles were quantitatively assessed using the Antera 3D® system .…”

Section: Vitaminsmentioning

confidence: 99%

“…Kwon et al evaluated the efficacy and safety of creams containing 0.05% and 0.1% retinaldehyde in a Figure 1 Sequence of conversions cosmeceutical retinoids undergo to become biologically active retinoic acid 3-month randomized, double-blind, controlled trial (n = 40). 10 Subjects applied the treatment twice daily for 3 months. 10 Wrinkles were quantitatively assessed using the Antera 3Dâ system.…”

Section: Retinaldehydementioning

confidence: 99%

“…10 Subjects applied the treatment twice daily for 3 months. 10 Wrinkles were quantitatively assessed using the Antera 3Dâ system. 10 Transepidermal water loss (TEWL), skin hydration, the melanin index, skin brightness, and overall improvement were also examined.…”

Section: Retinaldehydementioning

confidence: 99%

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Popular over‐the‐counter cosmeceutical ingredients and their clinical efficacy

2019

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The cosmeceutical market is a vast and rapidly growing global industry with hundreds of new products introduced each year. Patients often turn to cosmeceuticals to address their skin problems since these products are more accessible and affordable than prescription products. Unlike most drugs, cosmeceuticals do not undergo strict safety or efficacy testing by the FDA since they are classified as cosmetics. While the marketed properties of some ingredients are thoroughly researched and supported by clinical studies, not all ingredients have been tested to this standard, with some having only molecular or in vitro evidence and hardly any clinical authentication to support their use. Given these characteristics of the industry, dermatologists need to be familiar with cosmeceuticals in order to provide appropriate recommendations to their patients. The goal of this review was to explain the mechanism of action and evaluate the efficacy of popular cosmeceutical ingredients.

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“…10 As for melanin index, only the 0.1% retinaldehyde cream demonstrated a significant improvement. 10…”

Section: Retinaldehydementioning

confidence: 90%

Section: Vitaminsmentioning

confidence: 99%

Section: Retinaldehydementioning

confidence: 99%

Section: Retinaldehydementioning

confidence: 99%

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Popular over‐the‐counter cosmeceutical ingredients and their clinical efficacy

2019

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“…Retinal showed a significant reduction in wrinkles depth, size and roughness; [64]. More recently, this ingredient also showed to provide significant differences in fine wrinkles, skin roughness, TEWL reduction, hydration increase and melanin index [65].…”

Section: Othersmentioning

confidence: 96%

Evolution of the use of antioxidants in anti‐ageing cosmetics

Silva

Ferreira

Oliveira

et al. 2019

Intern J of Cosmetic Sci

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Objective Skin health and beauty are a cornerstone of general well‐being in humans. Anti‐ageing cosmetics are used to provide a healthy and youthful appearance. Among the different cosmetic actives, antioxidants are incorporated in anti‐ageing products due to their beneficial effects in preventing and minimizing the signs of skin ageing. This work aims to understand how anti‐ageing formulations changed in the past 7 years regarding pure antioxidants composition. Methods Data were collected from anti‐ageing formulations commercialized in main stores and pharmacies in the Portuguese market. The study started on 2011 and was updated with products launched or whose composition has been renewed on 2013, 2015 or 2018. Results Ascorbic acid and tocopherol and their derivatives were consistently the most used antioxidants in anti‐ageing formulations; followed by niacinamide and retinyl palmitate. Seven ascorbic acid derivatives are currently used in anti‐ageing formulations while only three tocopherol derivatives were identified in this study. Several combinations of antioxidants were routinely found, mainly tocopherol (or tocopherol derivatives) with other antioxidants and tocopherol with tocopherol derivatives. We have not identified emerging antioxidants with great impact in anti‐ageing formulations even though niacinamide and retinyl palmitate exhibited over 10% more usage in 2018. Conclusion This insight is relevant to the cosmetic industry providing a better understanding of the scientific‐based formulation of modern cosmetics and supports the need for innovative antioxidants in anti‐ageing cosmetics.

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