Efficacy and Safety of Rofecoxib in Patients with Chronic Low Back Pain

Katz, Nathaniel; Ju, William; Krupa, David; Sperling, Rhoda; Rodgers, Diana Bozalis; Gertz, Barry J.; Gimbel, Joseph; Coleman, Spencer; Fisher, Chester; Nabizadeh, Shahriar; Borenstein, David G.

doi:10.1097/01.brs.0000059762.89308.97

Cited by 44 publications

(4 citation statements)

References 36 publications

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“…The efficacy of prescribed anti-inflammatories, namely COX-2 selective inhibitors, in treating NeP hyper-inflammation remains unexplored. Existing research only demonstrated improved patient-reported outcomes for NoP cases [ [6] , [7] , [8] ]. This study demonstrated equivalent efficacy in patients taking prescribed anti-inflammatories for NeP and NoP.…”

Section: Discussionmentioning

confidence: 99%

“…Paracetamol (acetaminophen) and non-steroid anti-inflammatory drugs (NSAIDs) have anti-pyrectic and analgesic actions. Studies have only shown NSAIDs and paracetamol to be effective in patients with chronic LBP without sciatica and NeP signs [ [6] , [7] , [8] ]. The positioning of neuromodulating agents and opioids, is heavily debated by national and international guidelines in treating chronic LBP.…”

Section: Introductionmentioning

confidence: 99%

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Nociceptive pain assessed by the PainDETECT questionnaire may predict response to opioid treatment for chronic low back pain

Sima,

Lapkin,

Gan

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nociceptive pain assessed by the PainDETECT questionnaire may predict response to opioid treatment for chronic low back pain

Sima,

Lapkin,

Gan

et al. 2024

Heliyon

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“…При хронической неспецифической ПБ в сравнении с плацебо изучались напроксен [50], эторикоксиб [51], валь-декоксиб [52] и рофекоксиб [53]. Показана эффективность различных НПВП в отношении уменьшения боли, повышения функциональной активности, улучшения физического КЖ; не установлено преимущество какого-либо определенного НПВП перед другими [12,54].…”

Section: лекарственная терапияunclassified

Chronic nonspecific (musculoskeletal) low back pain. Guidelines of the Russian Society for the Study of Pain (RSSP)

Parfenov

Yakhno

Davydov

et al. 2019

RJTAO

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Examination of a patient with chronic low back pain (LBP) is aimed at eliminating its specific cause and assessing the social and psychological factors of chronic pain. The diagnosis of chronic nonspecific (musculoskeletal) LBP is based on the exclusion of a specific cause of pain, discogenic radiculopathy, and lumbar stenosis. It is advisable to identify possible pain sources: pathology of intervertebral disc pathology, facet joints, and sacroiliac joint and myofascial syndrome.An integrated multidisciplinary approach (a high level of evidence), including therapeutic exercises, physical activity optimization, psychological treatments (cognitive behavioral therapy), an educational program (back pain school for patients), and manual therapy, is effective in treating chronic musculoskeletal LBP. For pain relief, one may use nonsteroidal anti-inflammatory drugs in minimally effective doses and in a short cycle, muscle relaxants, and a capsaicin patch, and, if there is depressive disorder, antidepressants (a medium level of evidence). Radiofrequency denervation or therapeutic blockages with anesthetics and glucocorticoids (damage to the facet joints, sacroiliac joint), back massage, and acupuncture (a low level of evidence) may be used in some patients.Therapeutic exercises and an educational program (the prevention of excessive loads and prolonged static and uncomfortable postures and the use of correct methods for lifting weights, etc.) are recommended for preventive purposes.

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“…Effective therapies from drugs to surgery for CNLBP are widely used ( Ma et al, 2019 ). NSAIDs, such as Celecoxib and other COX-2 inhibitors are frequently advised for the treatment of CNLBP ( Birbara et al, 2003 ; Katz et al, 2003 ; Pallay et al, 2004 ; Airaksinen et al, 2006 ). The effectiveness of exercise therapy in CNLBP, including pilates, Tai Chi, yoga, and motor control exercise (MCE), has received greater attention in recent years ( van Middelkoop et al, 2011 ; Holtzman and Beggs, 2013 ; Macedo et al, 2013 ; Eliks et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Mawangdui-Guidance Qigong Exercise for patients with chronic non-specific low back pain: Study protocol of a randomized controlled trial

et al. 2023

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IntroductionWorldwide, there is a high frequency of chronic non-specific low back pain (CNLBP), which is a significant public health concern. The etiology is complicated and diverse, and it includes a number of risk factors such as diminished stability and weak core muscles. Mawangdui-Guidance Qigong has been employed extensively to bolster the body in China for countless years. However, the effectiveness of treating CNLBP has not been assessed by a randomized controlled trial (RCT). In order to verify the results of the Mawangdui-Guidance Qigong Exercise and examine its biomechanical mechanism, we intend to perform a randomized controlled trial.Methods and analysisOver the course of 4 weeks, 84 individuals with CNLBP will be randomly assigned to receive either Mawangdui-Guidance Qigong Exercise, motor control exercise, or medication (celecoxib). Electromyographic data, including muscle activation time, iEMGs, root mean square value (RMS) and median frequency (MF), will be the main outcomes. The Japanese Orthopedic Association (JOA) Score, the Mcgill Pain Questionnaire (MPQ), beta-endorphin, and substance P are examples of secondary outcomes. At the start of treatment and 4 weeks later, all outcomes will be evaluated. SPSS version 20.0 (SPSS Inc., Chicago, IL, USA) will be used for all of the analysis.DiscussionThe prospective findings are anticipated to offer an alternative treatment for CNLBP and provide a possible explanation of the mechanism of Mawangdui-Guidance Qigong Exercise on CNLBP.Ethics and disseminationThe Sichuan Regional Ethics Review Committee on Traditional Chinese Medicine has given the study approval (Approval No. 2020KL-067). It has also registered at the website of China Clinical Trial Center Registration. The application adheres to the Declaration of Helsinki’s tenets (Version Edinburgh 2000). Peer-reviewed papers will be used to publicize the trial’s findings.Trial registration numberClinicalTrials.gov, identifier ChiCTR2000041080.

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Efficacy and Safety of Rofecoxib in Patients with Chronic Low Back Pain

Abstract: Rofecoxib significantly reduced chronic low back pain in adults and was well tolerated.

Cited by 44 publications

References 36 publications

Nociceptive pain assessed by the PainDETECT questionnaire may predict response to opioid treatment for chronic low back pain

Nociceptive pain assessed by the PainDETECT questionnaire may predict response to opioid treatment for chronic low back pain

Chronic nonspecific (musculoskeletal) low back pain. Guidelines of the Russian Society for the Study of Pain (RSSP)

Mawangdui-Guidance Qigong Exercise for patients with chronic non-specific low back pain: Study protocol of a randomized controlled trial

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