Efficacy and safety of selamectin against Sarcoptes scabiei on dogs and Otodectes cynotis on dogs and cats presented as veterinary patients

Six, Robert H.; Clemence, R. G.; Thomas, C.A; Behan, S; Boy, M.; Watson, P; Benchaoui, H. A.; Clements, P.J.M; Rowan, T.G.; Jernigan, A.D

doi:10.1016/s0304-4017(00)00300-9

Cited by 76 publications

(74 citation statements)

References 22 publications

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“…The investigation was conducted as a multi-centre, controlled, randomized, blinded field study according to a non-inferiority design to demonstrate that the efficacy of the test product is not inferior to that of a control product (Stronghold® spot-on; Pfizer Santé Animale, Paris, France) containing selamectin, which is efficacious against S. scabiei and O. cynotis in dogs (Shanks et al 2000;Six et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of imidacloprid 10% plus moxidectin 2.5% spot-on in the treatment of sarcoptic mange and otoacariosis in dogs: results af a European field study

Krieger

Heine

Dumont³

et al. 2005

Parasitol Res

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Efficacy and safety of treatment with imidacloprid 10%+moxidectin 2.5% spot-on (Advocate, Advantage multi; Bayer AG, Leverkusen, Germany) were tested in dogs naturally infested with Sarcoptes scabiei or Otodectes cynotis in a multi-centre, controlled, randomized, blinded field study conducted in France, Germany, Albania and the UK. The study was performed according to a non-inferiority design to demonstrate that the efficacy of imidacloprid/moxidectin spot-on was not inferior to that of a control product containing selamectin (Stronghold spot-on; Pfizer). All Sarcoptes-infested dogs were topically treated twice (days 0 and 28) with the dosage recommended by the respective manufacturer (27 dogs with imidacloprid/moxidectin, 26 with selamectin). All Otodectes-infested dogs were treated on day 0 (35 dogs with imidacloprid/moxidectin, 34 with selamectin), and only those still positive on day 28 received a second treatment. Parasitological cure rate in Sarcoptes-infested dogs was 100% for both treatments, while parasitological cures rates in the Otodectes-infested dogs at day 28 and day 56 were 68.6 and 85.7% with imidacloprid/moxidectin, and 64.7 and 88.2% with Stronghold. Non-inferiority of Advocate was confirmed statistically. Clinical assessment of skin lesion scores at day 56 showed that with either product >96% of the dogs treated against sarcoptic mange were improved or cured, the difference between the groups being non-significant. On the basis of a final clinical assessment of lesion scores, 80% of the dogs treated with imidacloprid/moxidectin against otoacariosis and 85.3% of those treated with selamectin were rated cured or improved. Only three mild, possibly drug-related adverse reactions were observed among alI treated animals (two in the imidacloprid/moxidectin group, one in the selamectin group). It is concluded that imidacloprid/moxidectin spot-on is an effective and safe treatment for sarcoptic mange and otoacariosis in the dog.

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Section: Introductionmentioning

confidence: 99%

Efficacy and safety of imidacloprid 10% plus moxidectin 2.5% spot-on in the treatment of sarcoptic mange and otoacariosis in dogs: results af a European field study

Krieger

Heine

Dumont³

et al. 2005

Parasitol Res

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“…Recently, a novel avermectin, selamectin has proved to be very effective against ectoparasites and some endoparasites in cats and dogs , Jernigan et al 2000, Six et al 2000.…”

Section: Discussionmentioning

confidence: 99%

“…Earlier work with selamectin , Jernigan et al 2000, Six et al 2000 has confirmed that a single dose of 6-17.3 mg/kg has high efficacy against fleas, scabies, ticks, Toxocara canis, T. cati, T. leonina, Dirofilaria immitis and Ancylostoma tubaeforme in dogs and cats. However, the use of selamectin against other ectoand endoparasites in mice has not been reported.…”

mentioning

confidence: 98%

Efficacy of selamectin against mites (Myobia musculi, Mycoptes musculinus and Radfordia ensifera) and nematodes (Aspiculuris tetraptera and Syphacia obvelata) in mice

et al. 2006

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SummaryThe effects of selamectin were studied in mice naturally infected with the mites Myobia musculi, Myoceptes musculinus and Radfordia ensifera and with the oxyurid nematodes Aspiculuris tetraptera and Syphacia obvelata. The mice were divided into three treated and three control groups (n ¼ 9). Selamectin in the range 10-12.4 mg/kg was applied topically to the skin in a single spot at the base of the neck in front of the scapulae. The mice of treated and control groups were necropsied on the 4th, 7th and 21st day after the treatment. While selamectin was 100% effective in removing M. musculi, M. musculinus and R. ensifera by the seventh day, its effect against S. obvelata and A. tetraptera was 36.7% and 49.2%, respectively on the 21st day.

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“…Eles são reconhecidos como os principais causadores de otite externa nesses animais e, desta forma, têm importância considerável na clínica médica de pequenos (Six et al 2000, Lohse et al 2002. Acredita-se que o ácaro O. cynotis esteja envolvido em, aproximadamente, cinco a 10% dos casos de otite externa canina (Logas1994), valor que pode ser superior no Brasil, visto que Larsson (1987), em estudos realizados na cidade de São Paulo, verificou que 24,3% das otopatias em cães e gatos deviam-se às otites parasitárias.…”

Section: Introductionunclassified

Avaliação dos métodos de otoscopia e exame do swab parasitológico no diagnóstico da otocariose canina: uma abordagem bayesiana

et al. 2015

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Resumo Ácaros do gênero Otodectes são parasitos encontrados frequentemente no ouvido de cães e gatos, sendo reconhecidos como os principais causadores de otite externa nesses animais. Trezentos e vinte cães, oriundos do município de Cuiabá, Mato Grosso, foram examinados através da otoscopia e do exame do swab parasitológico, com o objetivo de avaliar, através da análise bayesiana para a estimativa da prevalência, sensibilidade e especificidade destes métodos no diagnóstico da infestação causada pelo ácaro utilizando-se de dados a priori informativos e não informativos. Cada animal foi considerado uma unidade experimental. Do total de cães examinados, 142 (44,37%) apresentaram-se positivos para otocariose. Em 100 animais (31,25%) a infestação foi diagnosticada pelos dois métodos, em 31 (9,69%) apenas pelo exame do swab parasitológico, em 11 (3,44%) apenas pela otoscopia e em 178 (55,62%) animais o resultado foi negativo por ambos os métodos. A sensibilidade da otoscopia, quando comparada ao exame do swab parasitológico, foi considerada menor, a especificidade dos testes, porém, não difere estatisticamente. O modelo, a priori informativo, demonstrou ser o mais plausível e reduziu consideravelmente o intervalo de credibilidade das estimativas dos parâmetros. Conclui-se que a análise bayesiana é efetiva na estimativa da prevalência e características dos testes diagnósticos.

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Efficacy and safety of selamectin against Sarcoptes scabiei on dogs and Otodectes cynotis on dogs and cats presented as veterinary patients

Cited by 76 publications

References 22 publications

Efficacy and safety of imidacloprid 10% plus moxidectin 2.5% spot-on in the treatment of sarcoptic mange and otoacariosis in dogs: results af a European field study

Efficacy and safety of imidacloprid 10% plus moxidectin 2.5% spot-on in the treatment of sarcoptic mange and otoacariosis in dogs: results af a European field study

Efficacy of selamectin against mites (Myobia musculi, Mycoptes musculinus and Radfordia ensifera) and nematodes (Aspiculuris tetraptera and Syphacia obvelata) in mice

Avaliação dos métodos de otoscopia e exame do swab parasitológico no diagnóstico da otocariose canina: uma abordagem bayesiana

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