Efficacy and safety of Sijunzi Decoction for peptic ulcers: A systematic review and meta-analysis

Huang, Xiaoyu; Sun, Xin; Yu, Xue; Qian, Huinan

doi:10.1016/j.jtcms.2018.11.001

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…2 This is usually caused by impaired mucosal against the offensive factors of the gastrointestinal tract. 3 Ulcers develop when the normal gastric equilibrium between the aggressive (acid and pepsin production and Helicobacter pylori) and protective mechanism (mucus and bicarbonate secretion, increased blood flow, cell turnover, permeability to H+ etc) are disturbed by enhanced aggressive factors or reduced defensive factors or both. 4 According to Khushtar et al, about 10% of the global population is affected and the annual new cases are is about four million annually and prevalence have shifted from have shifted from predominance in males to similar occurrence in both sexes while age group mostly affected are now increasingly older women and less frequently in younger men.…”

Section: Introductionmentioning

confidence: 99%

Comparative anti-ulcerogenic activities of the leaf, seed and stem bark hydromethanolic extracts of Picralima nitida in rats

Ezeja¹,

Igwe²,

Ikpeazu³

2020

Int J Basic Clin Pharmacol

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Background: Picralima nitida (Stapf) commonly called akuamma belongs to the family apocynaceae found mostly in forest areas of Africa. It is a shrub or a deciduous tree that can grow up to 35 meters in height. It has a cylindrical trunk measuring about 60 cm in diameter with white latex in its parts. The bark of the trunk is fragile and is greyish brown or black in colour.Methods: The acute oral toxicity test was done using up and down method. The anti-ulcerogenic activities of the leaf, seed and stem bark extracts were evaluated using ethanol-induced ulceration model in rats.Results: There were no signs of morbidity and mortality in rats following oral acute toxicity test. The extracts produced a significant (p<0.05) dose dependent reduction in the number of ulcers and ulcer scores reducing them from 14.00±2.82 and to 56.00±4.55 to as low as 2.00±1.21 and 8.45±1.24 respectively. The ulcer preventive index was also increased by P. nitida extracts in a dose dependent manner with the (Picralima nitida leaf extract) PNLE at the dose of 400 mg/kg causing up to 76.13% inhibition of ulcers in the rats.Conclusions: Picralima nitida extracts demonstrated significant anti-ulcerogenic activities in ethanol-induced gastric ulcerations in rats.

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Section: Introductionmentioning

confidence: 99%

Comparative anti-ulcerogenic activities of the leaf, seed and stem bark hydromethanolic extracts of Picralima nitida in rats

Ezeja¹,

Igwe²,

Ikpeazu³

2020

Int J Basic Clin Pharmacol

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“…[12–17] In TCM theory, most cases of PUD can be classified as spleen qi deficiency (SQD) syndrome, in which the patient's spleen (an abstract organ responsible for transporting and transforming food and water that differs from the organ in Western medicine) and qi (a kind of abstract energy that sustains life) are weakened by disease to the point that are unable to function normally, resulting in a range of gastrointestinal and systemic symptoms. [18] Therefore, the TCM treatment of SQD syndrome emphasizes invigorating spleen and replenishing qi to improve immunity and self-healing, and integrated TCM and routine treatments are expected to have greater efficacy against PUD.…”

Section: Introductionmentioning

confidence: 99%