Efficacy and safety of stellate ganglion block in chronic ulcerative colitis

Abstract

AIMTo investigate the efficacy and safety of stellate ganglion block for the treatment of patients with chronic ulcerative colitis.METHODSA total of 120 randomly selected patients with chronic ulcerative colitis treated in Cangzhou Central Hospital from January 2014 to January 2016 were included in this study. These patients were divided into two groups: control group (n = 30), patients received oral sulfasalazine treatment; experimental group (n = 90), patients received stellate ganglion block treatment. Clinical symptoms and disease activity in these two groups were compared before and after treatment using endoscopy. Blood was collected from patients on day 0, 10, 20 and 30 after treatment. Enzyme-linked immunosorbent assay was performed to determine interleukin-8 (IL-8) level. The changes in IL-8 level post-treatment in the two groups were compared using repeated measures analysis of variance.RESULTSAfter treatment, clinical symptoms and disease activity were shown to be alleviated by endoscopy in both the control and experimental groups. However, patients in the control group did not have obvious abdominal pain relief. In addition, the degree of pain relief in the experimental group was statistically better than that in the control group (P < 0.05). Ten days after treatment, IL-8 level was found to be significantly lower in the experimental group than in the control group, and the difference was statistically significant (P < 0.05). In addition, adverse events were significantly higher in the control group than in the experimental group, and the difference was statistically significant (χ2 = 33.215, P = 0.000).CONCLUSIONThe application of stellate ganglion block effectively improves treatment efficacy in chronic ulcerative colitis, relieves clinical symptoms in patients, and reduces the level of inflammatory factors. Furthermore, this approach also had a positive impact on the disease to a certain extent.

Effect of stellate ganglion block on postoperative recovery of gastrointestinal function in patients undergoing surgery with general anaesthesia: a meta-analysis

“…Stellate ganglion block (SGB) is currently the most commonly used sympathetic block in medical practice; it has a wide range of indications, including complex regional pain syndrome (CRPS) types 1 and 2, postherpetic neuralgia (PHN), intractable angina, post-traumatic stress disorder (PTSD), hyperhidrosis, arrhythmias, hot flushes, cerebrovascular disease and GI dysfunction [ 6 , 7 ]. It can also modify the immune response and inhibit inflammation after acute trauma [ 8 , 9 ].…”

Effect of stellate ganglion block on postoperative recovery of gastrointestinal function in patients undergoing surgery with general anaesthesia: a meta-analysis.

“…Based on this thesis, sympathetic blockade might play an important role in the recovery of GI function. Blockage of cervical sympathetic nerves has a long history as a medical technique; this approach promotes the establishment of homeostasis via regulation of the neuroendocrine-immune system [26], and the SG, which provides sympathetic input to the ipsilateral upper extremity, chest, face, and head, is the most commonly blockaded cervical ganglion, with wide applications [6,7].…”

Effect of Stellate Ganglion Block on Postoperative Recovery of Gastrointestinal Function in Patients Undergoing Surgery with General Anaesthesia: A Meta-Analysis.

“…Based on this thesis, sympathetic blockade might play an important role in the recovery of GI function. The blockage of cervical sympathetic nerves has a long history; this approach promotes the establishment of homeostasis via regulation of the neuro-endocrine-immune system [27], and the SG, which provides sympathetic input to the ipsilateral upper extremity, chest, face, and head, is the most commonly blockaded cervical ganglion, with wide applications [7,8]. SGB can be applied blindly or with imaging guidance (computed tomography, ultrasound) [6,28].…”

“…Stellate ganglion block (SGB) is currently the most commonly used sympathetic block in medical practice and has a wide range of indications, including complex regional pain syndrome (CRPS) types 1 and 2, postherpetic neuralgia (PHN), intractable angina, post-traumatic stress disorder (PTSD), hyperhidrosis, arrhythmias, hot ushes, cerebrovascular disease and GI dysfunction [7,8]. Additionally, it can modify the immune response and inhibit in ammation after acute trauma [9,10].…”