Efficacy and safety of the drug mexidol FORTE 250 as part of sequential therapy in patients with chronic ischemia of the brain

Ei, Chukanova; Chukanova, A. S.

doi:10.17116/jnevro201911909139

Cited by 31 publications

(2 citation statements)

References 5 publications

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“…For this reason, anticoagulant drugs are prescribed for atherosclerosis. Unfortunately, these drugs can also cause many serious adverse effects 24,25 . These methods also showed inconsistent efficacy 26‐28 .…”

Section: Discussionmentioning

confidence: 99%

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Targeted Delivery of Salusin‐α Into Rabbit Carotid Arterial Endothelium Using SonoVue

Wang

Luo

Mao

et al. 2021

J of Ultrasound Medicine

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Objectives A new method based on the adhesion of SonoVue to plasmids was assessed to achieve targeted gene delivery into the vascular endothelium. Methods pEGFP‐Salusin‐α and pcDNA3.1‐Salusin‐α plasmids were transfected into the arterial endothelium of different rabbit groups. Western blotting was performed to analyze the expression of EGFP and salusin‐α in the common carotid arteries of rabbits from different groups, and ELISA was performed to detect plasma salusin‐α levels in rabbits from each group; simultaneously, blood parameters of different groups of rabbits were measured. Results Green fluorescence was observed in the right common carotid artery of rabbits transfected with pEGFP‐Salusin‐α, but not in the endothelial cells of not‐transfected control rabbits. The expression of salusin‐α in the transfected animals was higher than that in the control not‐transfected animals (P < .05). In rabbits transfected with pcDNA3.1‐Salusin‐α plasmid, salusin‐α expression was higher than in the not‐transfected control animals (P < .05). However, there was no significant difference in plasma salusin‐α levels between transfected animals and controls (P > .05). Blood parameters were also measured in both groups. Conclusions Our data confirm the establishment of a new method using SonoVue for targeted gene delivery into the arterial endothelium. Our study outcomes propose a new method of intervention in atherosclerosis and a new tool for targeted gene delivery.

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Section: Discussionmentioning

confidence: 99%

“…Unfortunately, these drugs can also cause many serious adverse effects. 24 , 25 These methods also showed inconsistent efficacy. 26 , 27 , 28 Currently, interventions for atherosclerotic stenosis, or occlusion include recanalization, reconstruction, bypass grafting, and endovascular stents.…”

Section: Discussionmentioning

confidence: 99%