Efficacy and Safety of Traditional Chinese Medicine for Diabetes: A Double-Blind, Randomised, Controlled Trial

Ji, Linong; Tong, Xiaolin; Wang, Hongyuan; Tian, Haoming; Zhou, Huimin; Zhang, Lili; Li, Qifu; Wang, Yizhong; Li, Hongmei; Liu, Min; Yang, Hongjie; Gao, Yanbin; Li, Yan; Li, Quanmin; X, Guo; Yang, Gangyi; Zhang, Zhongai; Zhang, Zhou; Ning, Guang; Chen, Yingli; Paul, Sanjoy K.

doi:10.1371/journal.pone.0056703

Cited by 80 publications

(87 citation statements)

References 14 publications

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“…The therapeutic effect of this TCM on diabetes or DN has been identified by previous studies (33)(34)(35). The present study demonstrated that SKC-YJ treatment is effective in improving clinical syndromes, including reducing proteinuria, blood glucose levels, HBAlc, blood lipids and blood viscosity, as well as increasing the serum albumin level.…”

Section: Discussionsupporting

confidence: 72%

Clinical efficacy of ‘Spleen-kidney-care’ Yiqi Huayu and Jiangzhuo traditional Chinese medicine for the treatment of patients with diabetic nephropathy

Liu¹,

Zheng²,

Li³

2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the effect of the traditional Chinese medicine (TCM), ʻSpleen-kidney-careʼ Yiqi Huayu and Jiangzhuo decoction (SKC-YJ), as an adjuvant therapy in diabetic nephropathy (DN) treatment. In total, 72 patients with DN were randomly divided into control (n=54) and experimental (n=18) groups, with the latter administered SKC-YJ treatment. Indicators for determining the condition of the patients included the levels of proteinuria, blood glucose, glycosylated hemoglobin, blood lipids, blood viscosity and C-reactive protein, which were used to analyze the treatment protocols for DN. Following SKC-YJ treatment, the urinary albumin excretion rate, fasting blood glucose, 2 h-postprandial blood glucose, glycosylated hemoglobin, triglyceride, total cholesterol, blood viscosity, fibrinogen and C-reactive protein levels were detected in the two groups, and were all demonstrated to decrease significantly following treatment with SKC-YJ. Furthermore, the results revealed that SKC-YJ treatment exhibited no significant side-effects on the blood, liver and renal functions or gastrointestinal reactions. By contrast, SKC-YJ improved the symptoms of nausea, vomiting and diarrhea in the patients with DN, while showing no allergic reaction during the observation period. Therefore, SKC-YJ treatment was shown to significantly improve the clinical efficacy of DN treatment, illustrating novel roles for TCM in DN treatment. IntroductionAn increasing number of studies have revealed that the incidence of diabetes is based on the relative or absolute deficiency of insulin secretion from islet β-cells, which is caused by high levels of blood glucose (1-3). Diabetes is characterized by chronic, systemic metabolic disorders, while diabetic nephropathy (DN) is a systemic complication of diabetes. DN is a progressive kidney disease caused by angiopathy of the capillaries in the kidney glomeruli (4) and is characterized by nephrotic syndrome and diffuse glomerulosclerosis. DN is one of the most serious, chronic complications of diabetes, seriously affecting the life of patients, and in certain cases, resulting in mortality (5).According to traditional Chinese medicine (TCM) syndrome differentiation typing, DN is classified as a variety of types, including 'Thirsty', 'Consumption' and 'Edema' (6). Specifically, DN is associated with congenital deficiency, diet, emotional disorders, excessive labor and fever. Currently, TCM considers the pathogenesis of DN to be involved in spleen and kidney deficiency. Qi is the driving force of life activities and Yin is the material basis of life activities (7). Damage of Qi is more common in early DN (8), and as the disease progresses, DN gradually causes the damage of Yin (8-10).Disease of the islet β-cells is closely associated with the spleen (11). Modern medicine and TCM considers the kidney to be associated with the nervous, endocrine, reproductive, exercise, breathing, digestion, water metabolism, blood and immune systems, as well as other abnormal physi...

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Section: Discussionsupporting

confidence: 72%

Clinical efficacy of ‘Spleen-kidney-care’ Yiqi Huayu and Jiangzhuo traditional Chinese medicine for the treatment of patients with diabetic nephropathy

Liu¹,

Zheng²,

Li³

2015

Experimental and Therapeutic Medicine

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“…In diabetes patients, TCM herbs such as Rhizoma Coptidis, Radix Rehmanniae Recens, Radix Ginseng, Radix Puerariae, Radix Astragali seu Hedysari, Radix Bupleuri, Radix et Rhizoma Rhei, Radix Scutellariae, Radix Trichosanthis, Fructus Mume and Rhizoma Anemarrhenae have been shown to effectively lower blood glucose and improve clinical outcomes. We assessed 12 RCTs that focused on TCM and diabetes and had the following Jadad scores: 7 (six reports), 6 (one report), 5 (four reports) and 4 (one report). Sample sizes ranged from 79 to 800, and follow‐up duration ranged from 12 to 48 weeks.…”

Section: Resultsmentioning

confidence: 99%

Evidence and potential mechanisms of traditional Chinese medicine for the treatment of type 2 diabetes: A systematic review and meta‐analysis

Tian

Jin

Bao

et al. 2019

Diabetes Obesity Metabolism

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Traditional Chinese medicine (TCM) has recorded knowledge of diabetes for over 2000 years. Because a considerable number of TCM studies exhibit design defects, such as limited intervention duration, small sample sizes and inconsistent efficacy evaluations, the role of TCM in the treatment of diabetes cannot be fully elucidated. In this review, we evaluate randomized controlled trials of prediabetes, diabetes and diabetic complications published in the past decade. We found that TCM could significantly improve glucose control and clinical indices in patients with diabetes and effectively delay the progression of diabetes. We also summarize potential pharmacological mechanisms underlying the efficacy of TCM medication/herbs and their active ingredients for treating diabetes. More rigorously designed experiments and long-term evaluation of TCM for diabetes will allow for more effective diabetes management. K E Y W O R D S diabetes, diabetic complications, pharmacological mechanisms, prediabetes, randomized controlled trials, traditional Chinese medicine 1 | INTRODUCTION The overall population of patients with diabetes has reached approximately 415 million and is estimated to rise further to nearly 642 million by 2040. 1 Vast amounts of medical resources are spent on diabetes, and the total global health expenditure because of diabetes was estimated to be $673 billion in 2015; however, a decrease in the incidence of diabetes has not been observed. 1,2 About 5 million deaths are attributed to diabetes each year, and patients with an extended duration of complications lose their ability to work, thereby causing heavy social and economic burdens. Therefore, it is urgent to develop effective strategies to prevent the global health threat of diabetes. Traditional Chinese medicine (TCM) has focused on the treatment of diabetes for thousands of years. The "whole view" and "multi-targets" approaches of TCM provide unique advantages in controlling complex diseases such as diabetes. 3 TCM focuses on individualized treatments that are based on the differentiation of syndromes, control of balance and various routes of administration. 4,5 In recent years, large-scale clinical trials have confirmed that TCM has made progress in controlling blood glucose levels. Additionally, the application of modern science and technology has helped to uncover some of the therapeutic mechanisms underlying TCM's potency. Studies have been conducted to *Jiaxing Tian, De Jin and Fengmei Lian contributed equally to this study. Fengmei Lian and Xiaolin Tong are co-corresponding authors.

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“…Xiao Ke Wan is a fixed dose combination drug containing glyburide and various TCMs that have the antihyperglycaemic effect similar to that of glyburide. Compared with glyburide alone, Xiao Ke Wan carries a lower risk of hypoglycaemia …”

Section: Pharmacologic Therapy For Hyperglycaemiamentioning

confidence: 99%

Standards of medical care for type 2 diabetes in China 2019

Jia

Weng

Zhu

et al. 2019

Diabetes Metabolism Res

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518

452

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Summary The prevalence of diabetes in China has increased rapidly from 0.67% in 1980 to 10.4% in 2013, with the aging of the population and westernization of lifestyle. Since its foundation in 1991, the Chinese Diabetes Society (CDS) has been dedicated to improving academic exchange and the academic level of diabetes research in China. From 2003 to 2014, four versions of Chinese diabetes care guidelines have been published. The guidelines have played an important role in standardizing clinical practice and improving the status quo of diabetes prevention and control in China. Since September 2016, the CDS has invited experts in cardiovascular diseases, psychiatric diseases, nutrition, and traditional Chinese medicine to work with endocrinologists from the CDS to review the new clinical research evidence related to diabetes over the previous 4 years. Over a year of careful revision, this has resulted in the present, new version of guidelines for prevention and care of type 2 diabetes in China. The main contents include epidemiology of type 2 diabetes in China; diagnosis and classification of diabetes; primary, secondary, and tertiary diabetes prevention; diabetes education and management support; blood glucose monitoring; integrated control targets for type 2 diabetes and treatments for hyperglycaemia; medical nutrition therapy; exercise therapy for type 2 diabetes; smoking cessation; pharmacologic therapy for hyperglycaemia; metabolic surgery for type 2 diabetes; prevention and treatment of cardiovascular and cerebrovascular diseases in patients with type 2 diabetes; hypoglycaemia; chronic diabetic complications; special types of diabetes; metabolic syndrome; and diabetes and traditional Chinese medicine.

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Efficacy and Safety of Traditional Chinese Medicine for Diabetes: A Double-Blind, Randomised, Controlled Trial

Cited by 80 publications

References 14 publications

Clinical efficacy of ‘Spleen-kidney-care’ Yiqi Huayu and Jiangzhuo traditional Chinese medicine for the treatment of patients with diabetic nephropathy

Clinical efficacy of ‘Spleen-kidney-care’ Yiqi Huayu and Jiangzhuo traditional Chinese medicine for the treatment of patients with diabetic nephropathy

Evidence and potential mechanisms of traditional Chinese medicine for the treatment of type 2 diabetes: A systematic review and meta‐analysis

Standards of medical care for type 2 diabetes in China 2019

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