Efficacy and Safety of Tranexamic Acid for Reduction in Blood Transfusions in Patients Undergoing Major Non-Cardiac Surgeries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Fatima, Maurish; Ahmed, Aleena; Zaheer, Zaofashan; Zain, Ahmad; Azhar, Masood; Chaudhary, Muhammad Ahsan Hanif; Murad, Muhammad Wahaj; Khan, Muhammad Huzaifa Ahmed; Akbar, Usman Ali; Rehman, Mohammad Ebad Ur; Anwer, Faiz

doi:10.1182/blood-2022-165405

Cited by 3 publications

(1 citation statement)

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“…Anti brinolytic drugs have been regarded as safe and effective options for reducing blood loss. Among these drugs, tranexamic acid (TXA), a synthetic analog of lysine that acts as a brinolysis inhibitor, reversibly blocks the lysine sites on brinogen and, as a result, prevents the activation of plasmin and the lysis or breakdown of the polymer brin; TXA has been widely used because of its effectiveness in reducing blood loss in urological, cardiac, and orthopedic surgeries, including knee and hip arthroplasties 4 . TXA e cacy and safety have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the use of tranexamic acid in the postoperative period in patients with scoliosis undergoing posterior fusion

Carvalho,

Silva,

Neto

et al. 2024

Preprint

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Introduction: Scoliosis is the most prevalent type of spinal deformity, with a 2-3% prevalence in the general population. Moreover, surgery for scoliotic deformity may result in severe blood loss and, consequently, the need for blood transfusions, thereby increasing surgical morbidity and the rate of complications. Several antifibrinolytic drugs have been regarded as safe and effective options for reducing blood loss, among these drugs, the tranexamic acid. Therefor the present study aimed to analyze the effectiveness of this drug for controlling bleeding when used intraoperatively and in the first 48 h after surgery. Methods: A prospective randomized study of a cohort of patients included in a mass event for scoliosis treatment using PSF was performed. Twenty-eight patients were analyzed and divided into two groups: 14 patients were selected for intraoperative and postoperative use of tranexamic acid (TXA), and the other 14 were selected only during the intraoperative period. The drainage bleeding rate, length of hospital stay, number of transfused blood units, and rate of adverse clinical effects were compared. Results: All the patients involved had a similar number of fusion levels addressed and a similar scoliosis profile. The postoperative bleeding rate through the drain did not significantly differ between the two groups (p > 0.05). There was no significant difference in the number of transfused blood units between the groups (p=0.473); however, in absolute numbers, patients in the control group received more transfusions. The length of hospital stay was fairly similar between the groups, with no statistically significant difference. Furthermore, the groups had similar adverse effects (p=0.440), with the exception of nausea and vomiting, which were twice as common in the TXA group postoperatively than in the control group. Conclusions: No significant differences were found in the effective use of TXA during the first 48 postoperative hours.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the use of tranexamic acid in the postoperative period in patients with scoliosis undergoing posterior fusion

Carvalho,

Silva,

Neto

et al. 2024

Preprint

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Evaluation of the use of tranexamic acid in the postoperative period in patients with scoliosis undergoing posterior fusion

Carvalho,

da Luz Silva,

da Cruz Neto

et al. 2024

Neurosurg Rev

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Introduction: Scoliosis is the most prevalent type of spinal deformity, with a 2-3% prevalence in the general population. Moreover, surgery for scoliotic deformity may result in severe blood loss and, consequently, the need for blood transfusions, thereby increasing surgical morbidity and the rate of complications. Several anti brinolytic drugs have been regarded as safe and effective options for reducing blood loss, among these drugs, the tranexamic acid. Therefor the present study aimed to analyze the effectiveness of this drug for controlling bleeding when used intraoperatively and in the rst 48 h after surgery.Methods: A prospective randomized study of a cohort of patients included in a mass event for scoliosis treatment using PSF was performed. Twenty-eight patients were analyzed and divided into two groups: 14 patients were selected for intraoperative and postoperative use of tranexamic acid (TXA), and the other 14 were selected only during the intraoperative period. The drainage bleeding rate, length of hospital stay, number of transfused blood units, and rate of adverse clinical effects were compared.Results: All the patients involved had a similar number of fusion levels addressed and a similar scoliosis pro le. The postoperative bleeding rate through the drain did not signi cantly differ between the two groups (p > 0.05). There was no signi cant difference in the number of transfused blood units between the groups (p=0.473); however, in absolute numbers, patients in the control group received more transfusions. The length of hospital stay was fairly similar between the groups, with no statistically signi cant difference. Furthermore, the groups had similar adverse effects (p=0.440), with the exception of nausea and vomiting, which were twice as common in the TXA group postoperatively than in the control group.Conclusions: No signi cant differences were found in the effective use of TXA during the rst 48 postoperative hours.

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The use of tranexamic acid in paediatric adenotonsillectomy – A systematic review and meta-analysis

Hannigan,

Bumbak,

Brennan-Jones

et al. 2024

International Journal of Pediatric Otorhinolaryngology

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Efficacy and Safety of Tranexamic Acid for Reduction in Blood Transfusions in Patients Undergoing Major Non-Cardiac Surgeries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cited by 3 publications

References 0 publications

Evaluation of the use of tranexamic acid in the postoperative period in patients with scoliosis undergoing posterior fusion

Evaluation of the use of tranexamic acid in the postoperative period in patients with scoliosis undergoing posterior fusion

Evaluation of the use of tranexamic acid in the postoperative period in patients with scoliosis undergoing posterior fusion

The use of tranexamic acid in paediatric adenotonsillectomy – A systematic review and meta-analysis

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