Efficacy and safety of transdermal diclofenac patch versus intramuscular diclofenac injections in postoperative patients of inguinal hernia

Narzaree, Pranjit; Griwan, Mahavir Singh; Singh, Jasbir

doi:10.18203/2319-2003.ijbcp20160760

Cited by 3 publications

(2 citation statements)

References 12 publications

(15 reference statements)

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“…diclofenac in patients with inguinal hernia surgery as assessed by VAS and VRS. 20 In present study, three patients in Group K and six patients in Group D required rescue analgesic in 24 hours. There was no statistical significance was present on comparison of rescue analgesic in our study.…”

Section: Discussionmentioning

confidence: 58%

Comparison of efficacy and safety of ketoprofen patch versus diclofenac patch as post-operative analgesic in hysterectomy patients

Rani¹,

Savant²,

Mahendru³

et al. 2019

Int J Basic Clin Pharmacol

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Background: The objective of the study was to compare the efficacy and safety of ketoprofen patch versus diclofenac patch as post-operative analgesic in hysterectomy patients.Methods: The study was a prospective, single blind, randomized, comparative interventional clinical study conducted in a tertiary care hospital. Sixty female patients were randomly allocated to receive either ketoprofen or diclofenac patch 1 hour prior to the hysterectomy. Pain was assessed postoperatively after an interval of every four hours for 24 hours using visual analogue scale (VAS) and verbal rating scale (VRS).Results: In ketoprofen group, mean VAS was (2.92±0.11) significantly low as compared to diclofenac group (3.25±0.14). The mean VRS score in group ketoprofen (1.62±0.22) was low as compared to group diclofenac (1.83±0.16). Safety analysis revealed no apparent serious adverse events. Inj. Paracetamol 1 gm i.v was given as rescue analgesic to the patients in whom VRS >2 and VAS >5 was noted. Data were analysed using unpaired student’s t-test.Conclusions: Transdermal patches are very convenient to use and causes less discomfort as compared to traditional routes of drug delivery. Ketoprofen patch was found better in providing analgesia after hysterectomy as compared to diclofenac patch with lesser side effects.

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Section: Discussionmentioning

confidence: 58%

Comparison of efficacy and safety of ketoprofen patch versus diclofenac patch as post-operative analgesic in hysterectomy patients

Rani¹,

Savant²,

Mahendru³

et al. 2019

Int J Basic Clin Pharmacol

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“…These patches have increased the bioavailability, painless self-administration, maintenance of constant and stable drug levels, reduction of inter-and intra-patient variability, ease of medication termination, and maintenance of constant and stable drug levels. [6][7][8][9] Diclofenac patch has been studied mostly by dental surgeons after various dental surgeries 10 and our surgical colleagues in hernia surgeries, and the comparison has been with the intramuscular route for the use of inj diclofenac. Our study compared the…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Effects of Injecting Paracetamol and Transdermal Diclofenac Patch as Analgesics After Cesarean Birth

Sharma¹,

Chawla²,

Vivek³

et al. 2023

Journal of Obstetric and Gynaecological Practices POGS

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Introduction:Pain is an inevitable outcome of any surgery and control of postoperative pain is very important to improve patient comfort and reduce morbidity. The present study aims to compare the degree of postoperative pain relief using inj paracetamol and transdermal diclofenac patch after cesarean delivery. Materials and methods: A randomized controlled trial was done involving 200 women (100 women were involved in the transdermal diclofenac patch group and 100 women in the inj paracetamol group) to compare the efficacy of each drug as analgesia following cesarean delivery. Results: Both the statistical and clinical observations among the 200 patients showed that 100 mg diclofenac sodium administered transdermally as a patch has equal efficacy as compared with 1000 mg of paracetamol infusion given every 8 hours. Conclusion: Diclofenac patch and injection paracetamol as infusion have similar efficacy in providing postoperative pain relief for 24 hours after the cesarean delivery.

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Efficacy of diclofenac transdermal patch versus injection as post-cesarean analgesia: A clinical, comparative, single-blind randomized control trial

Dhamankar,

Javali,

Sunkad

2024

WJWCH

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Objectives: Post-operative pain is a common problem following cesarean delivery. The efficacy of topical application of diclofenac in alleviating pain has not been well established. We aim to evaluate the analgesic effect of transdermal diclofenac patch and compare it with the injectable form. Material and Methods: This is a prospective, randomized, single-blind, and placebo-controlled study. The study protocols and ethical considerations were adhered fully. Parturient women (n = 90) undergoing cesarean section were randomized into two equal groups: the transdermal diclofenac patch (Group A) and the injectable diclofenac (Group B). The surgery was performed under spinal anesthesia. The participant’s demographic data, clinical data, pain relief data collected, compiled, and analyzed using the Statistical Package for the Social Sciences 20. The post-operative pain was scored using Visual Analog Scale. Pain relief scores were compared between the groups using Mann–Whitney U-test and Wilcoxon matched-pair test. Results: The participants match in demographic and clinical characters. The pain relief scores at 12 h was – 3.10 ± 0.74 and 3.04 ± 0.21 respectively while at 24 hours was – 2.48 ± 0.51 and 2.09 ± 0.29 respectively in Group A and Group B. The difference between Group A and Group B was statistically significant (P = 0.0022). The pain relief scores in both groups match was statistically significant at 6–24 h and 6–48 h (P = 0.0001, 0.0001). Conclusion: Diclofenac transdermal patch gives equal pain relief as that of routine injectable formulation.

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Efficacy and safety of transdermal diclofenac patch versus intramuscular diclofenac injections in postoperative patients of inguinal hernia

Cited by 3 publications

References 12 publications

Comparison of efficacy and safety of ketoprofen patch versus diclofenac patch as post-operative analgesic in hysterectomy patients

Comparison of efficacy and safety of ketoprofen patch versus diclofenac patch as post-operative analgesic in hysterectomy patients

A Comparison of the Effects of Injecting Paracetamol and Transdermal Diclofenac Patch as Analgesics After Cesarean Birth

Efficacy of diclofenac transdermal patch versus injection as post-cesarean analgesia: A clinical, comparative, single-blind randomized control trial

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