No abstract

Ultrasonic velocities (u), densities (ρ), viscosities (η), relative permittivities (ε), and refractive indicies (n D) of mixtures of acetonitrile with dimethylacetamide, dimethyl sulfoxide, nitrobenzene, and methanol have been measured at 25 °C. From u, ρ, and η, isentropic compressibilities (κs), and its deviation from ideal behavior and excess viscosities (Δη) have been computed. From n D and ε, the Kirkwood correlation factor, g, has also been evaluated.

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Diabetic nephropathy (DN) has emerged as the major causative pathology in patients entering end-stage renal disease (ESRD) worldwide and it is responsible for 30-40% of all ESRD cases. Treatments for DN are centered on control of hyperglycemia and blood pressure control. However, current therapeutic regimens have not yet provided satisfactory prevention from the onset of DN. Protein kinase C (PKC) is an intracellular signaling molecule and activation of it plays an important role in the development of diabetic complications. In numerous experimental and clinical studies, inhibition of PKC (LY333531) has been shown to delay/halt the progression of diabetic complications. Presently, the drug is submitted in USA-FDA for new drug application in moderate to severe diabetic retinopathy. This review selectively discusses the role of PKC in DN and therapeutic effects produced by PKC inhibitors in DN. The role of PKC inhibitor in other diabetic complications is also discussed.

The research suggests that the root extract was significantly effective when compared with control and standard in the treatment of hyperlipidemia and hyperglycemia in diabetic rats. Therefore, it may be beneficial to diabetic patients.