Efficacy and Safety of Washed Microbiota Transplantation to Treat Patients with Mild-to-Severe COVID-19 and Suspected of Having Gut Microbiota Dysbiosis: Study Protocol for a Randomized Controlled Trial

Wu, Li‐Hao; Ye, Zhi-Ning; Peng, Ping; Xie, Wen-Rui; Xu, Jia-Ting; Zhang, Xueyuan; Xia, Harry Hua‐Xiang; He, Xiaofu

doi:10.1007/s11596-021-2475-2

Cited by 13 publications

(17 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some articles also evaluated the effect of probiotics on COVID-19 infection. The majority of the studies found the probiotics bene cial for COVID-19 patients' recovery [23,[30][31][32][33][34][35][36][37][38][39][40][41]. One study evaluated the positive e cacy of FMT (Fecal microbial transplantation) for COVID-induced GI upset [35].…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies included in our review assessed the effects of probiotic implementations on symptoms, morbidity, and mortality rates among COVID-19 patients [23,[30][31][32][33][34][35][36][37][38][39][40][41]. Probiotics are live microorganisms whose administration in su cient quantities has been demonstrated to ameliorate immune response, participate in metabolism, and balance the host microbiome [166,167].…”

Section: Probiotic Implementationmentioning

confidence: 99%

“…In addition, few studies had utilized other less common probiotics as follows; Bos taurus, Morone, Leuconostoc, Lachesana, Limulus, Oryctolagus, Pentadiplandra, Rhamnosus, and Enterococcus [30,33,40]. Moreover, two studies utilized distinguished methods for balancing patients' altered microbiome including; Fecal microbiota transplantation (FMT) [35] and washed microbiota transplantation (WMT) [39], and two studies didn't specify the exact type of studied probiotic [32,34]. Almost all these studies reported a diverse variety of probiotics' bene cial effects in combat against COVID-19 symptoms, prognosis, and outcome.…”

Section: Probiotic Implementationmentioning

confidence: 99%

“…Finally, Fecal microbiota transplantation (FMT) was reported to be a novel therapy with bene cial effects as follows; increasing microbial richness, restoring gut microbiota through decreasing Proteobacteria, and increasing Bi dobacterium, Faecalibacterium, and Actinobacteria, and alleviating GI symptoms [35]. Similarly, washed microbiota transplantation (WMT) was reported to be effective and safe for COVID-19 patients [39]. Therefore, Lactobacilli and Bi dobacteria can be considered the main probiotics that can assist the most with balancing gut microbiome and possibly correct the dysbiosis caused by COVID-19.…”

Section: Probiotic Implementationmentioning

confidence: 99%

See 3 more Smart Citations

Gut microbiota and COVID-19: A systematic review

SeyedAlinaghi

Afzalian

Pashaei

et al. 2022

Preprint

View full text Add to dashboard Cite

Introduction: Alteration in humans’ gut microbiota was reported in patients infected with SARS-CoV-2. The gut and upper respiratory tract microbiota harbor a dynamic and complex population of microorganisms and have strong interaction with host immune system homeostasis. However, our knowledge about microbiota and its association with SARS-CoV-2 is still limited. We aimed to systematically review the effects of gut microbiota on the COVID-19 infection and its severity and the impact that SARS-CoV-2 could have on the gut microbiota.Methods: We searched the keywords in the online databases of Web of Science, Scopus, PubMed, and Cochrane on December 31st, 2021. After duplicate removal, we performed the screening process in two stages; title/abstract and then full-text screening. The data of the eligible studies were extracted into a pre-designed word table. This study adhered to the PRISMA checklist.Results: Sixty-three publications were included in this review. It appeared that COVID-19 infection could affect the microbiome in patients, particularly in moderate and severe cases. The severity of COVID-19 disease may also be influenced by the microbiota's composition through immunological responses or some other unknown mechanisms.Conclusion: Our study showed that there was a significant change in the composition of the upper respiratory tract and gut microbiome in patients with COVID-19 compared to healthy individuals. These apparent changes suggested gut and upper respiratory tract microbiota as a possible indicator for diagnosis and strategy for the treatment of COVID-19.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Probiotic Implementationmentioning

confidence: 99%

Section: Probiotic Implementationmentioning

confidence: 99%

Section: Probiotic Implementationmentioning

confidence: 99%

See 2 more Smart Citations

Gut microbiota and COVID-19: A systematic review

SeyedAlinaghi

Afzalian

Pashaei

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Given the gut microbiota-targeted positive effects by means of probiotics on GI and clinical symptoms in COVID-19 patients [ 222 ], Wu and colleagues (2021) are currently undertaking a clinical trial to establish whether FMT can treat gut microbiota dysbiosis. In particular, they will assess FMT clinical efficacy on GI symptoms, COVID-19 status, recovery from the disease, the inflammatory response, the intestinal mucosal barrier function, as well the clearance time of SARS-CoV-2 from feces [ 223 ].…”

Section: Fecal Microbiota Transplantation In Human Diseasesmentioning

confidence: 99%

Fecal Microbiota Transplantation as New Therapeutic Avenue for Human Diseases

Biazzo

Deidda

2022

JCM

View full text Add to dashboard Cite

The human body is home to a variety of micro-organisms. Most of these microbial communities reside in the gut and are referred to as gut microbiota. Over the last decades, compelling evidence showed that a number of human pathologies are associated with microbiota dysbiosis, thereby suggesting that the reinstatement of physiological microflora balance and composition might ameliorate the clinical symptoms. Among possible microbiota-targeted interventions, pre/pro-biotics supplementations were shown to provide effective results, but the main limitation remains in the limited microbial species available as probiotics. Differently, fecal microbiota transplantation involves the transplantation of a solution of fecal matter from a donor into the intestinal tract of a recipient in order to directly change the recipient’s gut microbial composition aiming to confer a health benefit. Firstly used in the 4th century in traditional Chinese medicine, nowadays, it has been exploited so far to treat recurrent Clostridioides difficile infections, but accumulating data coming from a number of clinical trials clearly indicate that fecal microbiota transplantation may also carry the therapeutic potential for a number of other conditions ranging from gastrointestinal to liver diseases, from cancer to inflammatory, infectious, autoimmune diseases and brain disorders, obesity, and metabolic syndrome. In this review, we will summarize the commonly used preparation and delivery methods, comprehensively review the evidence obtained in clinical trials in different human conditions and discuss the variability in the results and the pivotal importance of donor selection. The final aim is to stimulate discussion and open new therapeutic perspectives among experts in the use of fecal microbiota transplantation not only in Clostridioides difficile infection but as one of the first strategies to be used to ameliorate a number of human conditions.

show abstract

Retracted: Gut microbiota and COVID‐19: A systematic review

SeyedAlinaghi

Afzalian

Pashaei

et al. 2023

Health Science Reports

View full text Add to dashboard Cite

Background and Aims Alteration in humans' gut microbiota was reported in patients infected with severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). The gut and upper respiratory tract (URT) microbiota harbor a dynamic and complex population of microorganisms and have strong interaction with host immune system homeostasis. However, our knowledge about microbiota and its association with SARS‐CoV‐2 is still limited. We aimed to systematically review the effects of gut microbiota on the SARS‐CoV‐2 infection and its severity and the impact that SARS‐CoV‐2 could have on the gut microbiota. Methods We searched the keywords in the online databases of Web of Science, Scopus, PubMed, and Cochrane on December 31, 2021. After duplicate removal, we performed the screening process in two stages; title/abstract and then full‐text screening. The data of the eligible studies were extracted into a pre‐designed word table. This study adhered to the PRISMA checklist and Newcastle−Ottawa Scale Bias Assessment tool. Results Sixty‐three publications were included in this review. Our study shows that among COVID‐19 patients, particularly moderate to severe cases, the gut and lung microbiota was different compared to healthy individuals. In addition, the severity, and viral load of COVID‐19 disease would probably also be influenced by the gut, and lung microbiota's composition. Conclusion Our study concludes that there was a significant difference in the composition of the URT, and gut microbiota in COVID‐19 patients compared to the general healthy individuals, with an increase in opportunistic pathogens. Further, research is needed to investigate the probable bidirectional association of COVID‐19 and human microbiome.

show abstract

Efficacy and Safety of Washed Microbiota Transplantation to Treat Patients with Mild-to-Severe COVID-19 and Suspected of Having Gut Microbiota Dysbiosis: Study Protocol for a Randomized Controlled Trial

Cited by 13 publications

References 27 publications

Gut microbiota and COVID-19: A systematic review

Gut microbiota and COVID-19: A systematic review

Fecal Microbiota Transplantation as New Therapeutic Avenue for Human Diseases

Retracted: Gut microbiota and COVID‐19: A systematic review

Contact Info

Product

Resources

About