Efficacy and safety of Xiaofeng powder (xiao feng san) in treating urticaria

Chen, Guo-Ming; Zhao, Jinlong; Chen, Tengyu; Zhang, Zhaoping; Huang, Chuyao; Xu, Zhirui; Xu, Haowen

doi:10.1097/md.0000000000013039

Cited by 4 publications

(1 citation statement)

References 26 publications

(18 reference statements)

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“…The main reason they quote this is that MFEP requires ensemble averages. SDP when used properly can accelerate the optimization of MFEP [11].…”

Section: Literature Reviewmentioning

confidence: 99%

A comparison between steepest descent and non-linear conjugate gradient algorithms for binding energy minimization of organic molecules

Akshaya,

Rahul,

Rishi Karthigayan

et al. 2023

J. Phys.: Conf. Ser.

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The main intention of optimization is to bring about the “best” of any model by prioritizing the needs along with a given set of constraints. There is a wide range of optimization problems, among which, unfortunately, the problems that are formulated from nature are not convex in nature. Solving non-convex optimization problems are quite trickier than the conventional method of derivatives. One such problem is Computing the minimum value of binding free energy of various molecules. Minimization of free energy of a molecule is highly significant in the field of Molecular mechanics which is the foundation of computational biology. For any molecule, free energy refers to the amount of energy needed to separate an individual particle from a system of particles or to disseminate all particles in a system. The significance of free energy is that it can be used to compute the lowest energy conformation, which corresponds to the least Steric energy. Hence, this paper aims at computing the minimum value of binding free energy of various organic molecules in isolated conditions using the steepest descent algorithm and conjugate gradient algorithm and comparing them.

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“…The main reason they quote this is that MFEP requires ensemble averages. SDP when used properly can accelerate the optimization of MFEP [11].…”

Section: Literature Reviewmentioning

confidence: 99%

A comparison between steepest descent and non-linear conjugate gradient algorithms for binding energy minimization of organic molecules

Akshaya,

Rahul,

Rishi Karthigayan

et al. 2023

J. Phys.: Conf. Ser.

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Emerging treatments for chronic urticaria

Wedi

2022

Expert Opinion on Investigational Drugs

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Efficacy and safety of modified Xiao-Feng Powder in the treatment of chronic urticaria: protocol of a randomized double-blind placebo-controlled study

et al. 2022

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Background Chronic Urticaria (CU), a common skin disorder known as Yin Zhen in Chinese medicine, is characterized by recurrent, pruritic, pink-to-red edematous lesions and wheals on the skin. Xiao-Feng Powder (XFP, meaning Wind-Dispersing Powder), is reported to be one of the most frequently used Chinese herbal formulae for CU. In this study, we aim to investigate the effectiveness and safety of modified Xiao-Feng Powder (mXFP) for the treatment of CU. Methods In this randomised double-blind placebo-controlled clinical trial, 58 subjects identified as having mild to severe urticaria (Urticaria activity score greater than 10) will be recruited and randomised into two groups to receive antihistamine Bilastine with either mXFP or placebo for 12 weeks, followed by post treatment visits at week 16. The primary outcome measure is the change of weekly urticaria activity score (UAS7) at week 12. Secondary outcome measures include the Urticaria Control Test (UCT), Visual Analog Scale of Itch Severity (VAS), Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL), Angioedema Activity Score (AAS), immunoglobulin E (IgE) test, gut microbiota test and use of antihistamines during study period. The trial will be conducted at three Chinese medicine clinics in Hong Kong. Expected outcomes The results of this study will establish robust clinical evidence about the efficacy and safety of mXFP in the treatment of CU. A specific feature of this trial is that it is a integrative medicine trial with subjects being allowed to take the Western and Chinese medicine together for the treatment. Trial registration This is registered on ClinicalTrials.gov, ID: NCT04967092. Register date: July 19, 2021. https://clinicaltrials.gov/ct2/show/NCT04967092.

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Efficacy and safety of Xiaofeng powder (xiao feng san) in treating urticaria

Cited by 4 publications

References 26 publications

A comparison between steepest descent and non-linear conjugate gradient algorithms for binding energy minimization of organic molecules

A comparison between steepest descent and non-linear conjugate gradient algorithms for binding energy minimization of organic molecules

Emerging treatments for chronic urticaria

Efficacy and safety of modified Xiao-Feng Powder in the treatment of chronic urticaria: protocol of a randomized double-blind placebo-controlled study

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