Efficacy and therapeutic reactions of tri-needle-pretreatment combined with painless ALA-PDT for the treatment of moderate-to-severe acne vulgaris: A randomized controlled trial

Shi, Lei; Yang, Yutong; Zhang, Linglin; Jia, Yan; Zhang, Haiyan; Li, Chunxiao; Zhang, Yunfeng; Liu, Xiaojing; Zhou, Zhongxia; Wang, Xiuli

doi:10.1016/j.pdpdt.2021.102680

Cited by 11 publications

(2 citation statements)

References 20 publications

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“…Similarly, good results were achieved for acne by reducing the drug dose to 5% [31,32]. However, a limit to ALA dose reduction has been recently presented by He et al, showing that too low concentrations of ALA (0.1/0.5 mmol/L) might promote the growth of C. acnes, whereas higher doses (1.0 /2.5 mmol/L) inhibit it [33].…”

Section: Discussionmentioning

confidence: 98%

Long-Term Improvement of Different Types of Acne Vulgaris Using a Mild Photodynamic Therapy Protocol with BF-200 ALA Gel: A Series of Cases

Serra-Guillén,

Llombart,

Sanmartín

2024

JCM

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Background: Photodynamic therapy (PDT) can be a promising alternative for patients with acne vulgaris. Our study aimed to evaluate the efficacy and safety of red light photodynamic therapy with BF-200 ALA gel in the treatment of different types of acne vulgaris. Methods: We performed a retrospective, observational study of a series of 22 cases. All patients were treated according to a mild PDT protocol. After a careful wash of the affected skin areas, BF-200 ALA gel was applied to the skin in a thin layer and incubated for 30 min, followed by illumination using narrow-spectrum red light (635 nm) at a dose of 4 J/cm2. Most patients received one (36.4%), two (27.3%), or three (22.7%) PDT sessions. About a third of the patients received concomitant acne treatment with topical retinoids. Results: Patients of 25.1 ± 8.9 years suffering from papulopustular (45.5%), nodular (27.3%), and comedonal acne (27.3%) in the face were included. Irrespective of acne type or severity, 95.5% of patients had good or excellent responses to the treatment with PDT (≥60% lesion clearance). We found no association between concomitant acne medication and the favorable results achieved by PDT. Most patients reported no adverse events (72.7%), except for six patients who experienced erythema. The good efficacy results were maintained over a follow-up period of 12.5 ± 10.8 months. Conclusions: In this study, we show that PDT with BF-200 ALA gel and low light dose is an effective and long-lasting option for the treatment of different acne types.

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Section: Discussionmentioning

confidence: 98%

Long-Term Improvement of Different Types of Acne Vulgaris Using a Mild Photodynamic Therapy Protocol with BF-200 ALA Gel: A Series of Cases

Serra-Guillén,

Llombart,

Sanmartín

2024

JCM

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“…17 It is also considered an effective treatment for skin diseases such as psoriasis, vitiligo, and acne. [18][19][20] According to the literature review, fire needle therapy can accelerate local blood circulation and reduce pathological changes in local tissue such as edema, congestion, and exudation. 21 Furthermore, the fire needle directly stimulates the lesion and raises the skin temperature around the lesion, thus accelerating metabolism and promoting the repair of damaged tissue.…”

Section: Introductionmentioning

confidence: 99%

Fire Needle Combined Topical Mupirocin for the Treatment of Simple Skin Abscesses in Pediatric Patients: A Case Series

Li¹,

Zhu²,

Cao³

et al. 2023

IDR

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Background: Skin abscesses are a common skin condition usually caused by bacterial infections and their incidence is increasing in children. Its current management strategy is still mainly incision and drainage, sometimes with antibiotics. In pediatric patients, surgical incision and drainage of skin abscesses is challenging compared to in adults because of their specific age and psychological characteristics and high aesthetic requirements. Therefore, it is important to seek better treatment options. Patients and methods: We reported 17 cases of skin abscesses in pediatric patients aged 1 to 9 years. Ten cases had lesions on the face and neck and 7 cases on the trunk and limbs. They all received treatment based on fire needle combined with topical mupirocin. Results:The lesions of all 17 pediatric patients healed within 4 to 14 days, with a median time of 6 days, and all achieved satisfactory results with no scarring left behind. No adverse events were observed in all patients, and no recurrence occurred within 4 weeks. Conclusion: For skin abscesses in pediatric patients, early application of a combination therapy based on fire needle is convenient, aesthetic, economical, safe and clinically important as an alternative to incision and drainage, and deserves further clinical promotion.

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5-Aminolevulinic acid photodynamic therapy versus minocycline for moderate-to-severe rosacea: A single-center, randomized, evaluator-blind controlled study

Yang,

Liu,

Cao

et al. 2023

Journal of the American Academy of Dermatology

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Efficacy and therapeutic reactions of tri-needle-pretreatment combined with painless ALA-PDT for the treatment of moderate-to-severe acne vulgaris: A randomized controlled trial

Cited by 11 publications

References 20 publications

Long-Term Improvement of Different Types of Acne Vulgaris Using a Mild Photodynamic Therapy Protocol with BF-200 ALA Gel: A Series of Cases

Long-Term Improvement of Different Types of Acne Vulgaris Using a Mild Photodynamic Therapy Protocol with BF-200 ALA Gel: A Series of Cases

Fire Needle Combined Topical Mupirocin for the Treatment of Simple Skin Abscesses in Pediatric Patients: A Case Series

5-Aminolevulinic acid photodynamic therapy versus minocycline for moderate-to-severe rosacea: A single-center, randomized, evaluator-blind controlled study

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