Efficacy and tolerability of 8 weeks’ treatment with terbinafine in children with tinea capitis caused by Microsporum canis: a comparison of three doses

Abstract

The administration of terbinafine at a dose of either 6-7 or 7-12.5 mg/kg/day for 8 weeks is safe and effective for the treatment in children of tinea capitis caused by M. canis.

Terbinafine hydrochloride oral granules versus oral griseofulvin suspension in children with tinea capitis: Results of two randomized, investigator-blinded, multicenter, international, controlled trials∗

“…Several studies suggest a linear relationship between cure rate and weightadjusted daily dose of terbinafine. 21,26,31,32 A phase II study has demonstrated the efficacy of a 2-week treatment with standard terbinafine tablets (3-6 mg/kg per day) in children with T tonsurans tinea capitis. 21 Terbinafine hydrochloride oral granules have been developed as a new pediatric formulation consisting of miniature granules that can be sprinkled over food and easily swallowed.…”

Tinea capitis caused by Microsporum canis treated with terbinafine

“…The microsporum forms are considerably more resistant than trichophyton; thus it would appear advisable to consider patient groups separately in order to define treatment duration according to the fungi at the root of the disease. Recently, several authors reported that an increase to 7 mg day −1 terbinafine dosage may lead to elevated cure rates within 8 weeks of treatment 17 . We deem that further studies are necessary to standardize this higher dosage, which should be extremely useful for the treatment of tinea capitis caused by M. canis , if free of side effects.…”

“…Recently, several authors reported that an increase to 7 mg day )1 terbinafine dosage may lead to elevated cure rates within 8 weeks of treatment. 17 We deem that further studies are necessary to standardize this higher dosage, which should be extremely useful for the treatment of tinea capitis caused by M. canis, if free of side effects.…”

S1 guidelines: Tinea capitis

“…Though effective against all dermatophyte species in vitro [55], the agent has been shown to be more effective against Trichophyton spp. While efficacy against the latter may be increased by upping the dosage, this renders the drug no more effective than griseofulvin [76]. [2,80].…”

“…than of ectothrix infections (for example, M. canis). Controlled clinical trials have demonstrated that antifungal therapy should be guided by the causative species (Table 1) [68][69][70][71][72][73][74][75][76][77][78][79][80][81][82]. In a recent review, Gupta et al [68] summarized the results of 21 randomized and 17 non-randomized controlled trials.…”