Efficacy and tolerability of a hyaluronic acid‐based serum and a peptide‐rich cream for the face and neck in subjects with photodamaged skin

Abstract

Skin aging is a complex process resulting in cumulative structural and physiological alterations of the extracellular matrix, which is rich in both collagen and hyaluronic acid. Hyaluronic acid (HA) and peptides are critical ingredients often incorporated into skincare formulations to help supplement and support photoaged skin. HA works by binding and retaining water molecules to hydrate skin; peptides are signaling molecules that regulate fibroblasts and support collagen. 1,2 However, while small molecule (≤500 Da maximum

Macrocystis pyrifera ferment‐containing creams for optimizing facial skin rejuvenation

“…Applying the two products for 12 weeks visibly improved face and neck texture, tone, lines, and wrinkles. No study‐product‐related adverse events were reported, and subjects reported high levels of satisfaction 5 …”

Retinoids—A unique ingredient for skin rejuvenation employing novel drug delivery systems

“…With increasing age, the lysis of thymidine bonds ceases leading to irreversible mutations [62]. Extrinsic aging owes to the lowered expression of type VII collagen in keratinocytes which leads to skin creasing and decreased levels of collagen type I [73]. In contrast, to the healthy skin section, the aged skin tends to show drastically different properties like invagination of the epidermis coupled with decreased collaged and HA deposition as depicted in Figure 2.…”

“…A low concentration of retinol-0.1% when formulated into a cream using HA and DMC in the formulation exhibits a long-term anti-aging benefit on the facial skin [84]. HA is a mucopolysaccharide that helps to hold water molecules in the skin and supports collagen development [73]. Likewise, HA increases keratinocyte expansion through the stimulation of the CD44 receptor in the skin [84].…”