Efficacy and tolerability of a pasteurised human fibrinogen concentrate in patients with congenital fibrinogen deficiency

The use of fibrinogen concentrate to correct hypofibrinogenaemia rapidly during obstetric haemorrhage

“…A number of recent case series and retrospective studies have indicated that fibrinogen concentrate is well tolerated and effective in arresting haemorrhage in patients with congenital and acquired hypofibriniogenaemia. [10][11][12][13][14][15] Furthermore, it appears to be effective in reversing dilutional coagulopathy following crystalloid and colloid administration during orthopaedic surgery. 16 We report the use of fibrinogen concentrate to rapidly correct hypofibrinogenaemia during six cases of obstetric haemorrhage with diverse aetiology.…”

Dysfibrinogenemia in a patient undergoing artificial abortion after misdiagnosis and review of the literature

“…The normal fibrinogen concentration ranges from 2.0 to 4.5 g/l [7]. Fibrinogen is synthesized in the rough endoplasmic reticulum of liver cells and secreted into the circulation through various processing, folding, and assembly maneuvers [8].…”

Disseminated Intravascular Coagulation in Obstetrics: Ethiopathogenesis and up to date Management Strategies

“…Since the fibrinogen consumption may be faster , fibrinogen concentrates should be administered for values above 1gm/L in DIC. 4 gm of fibrinogen concentrates, increase serum fibrinogen levels to 1gm/L (68) . In a study done on 30 patients with acquired hypofibrinogenemia, i.e.…”