1999
DOI: 10.2165/00044011-199918030-00010
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Efficacy and Tolerability of Once-Daily Grepafloxacin Compared with Clarithromycin in the Treatment of Acute Bacterial Exacerbations of Chronic Bronchitis*

Abstract: Objectives: The clinical and bacteriological efficacies and tolerability of grepafloxacin 400mg once daily for 10 days were compared with clarithromycin 500mg twice daily for 10 days in patients with acute bacterial exacerbations of chronic bronchitis (ABECB). Patients and Study Design: 379 patients with signs and symptoms of ABECB were enrolled in a randomised, double-blind clinical trial conducted at 15 outpatient centres in the USA. Eligible patients were randomly assigned to receive either grepafloxacin pl… Show more

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