Efficacy and tolerability of racecadotril in acute diarrhea in children

Cézard, Jean Pierre; Duhamel, J; Meyer, Martine De; Pharaon, I.; Bellaïche, M.; Maurage, C.; Giniès, J.L.; Vaillant, Jean; Girardet, J.-P.; Lamireau, T.; Poujol, A.; Morali, A.; Sarles, J.; Olives, Jean Pierre; Whately‐Smith, Caroline; Audrain, Sylvie; Lecomte, J

doi:10.1053/gast.2001.22544

Cited by 105 publications

(103 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…14 Baumer et al and Cezard et al also showed similar results. 15,16 Results of present study have established the efficacy of racecadotril in decreasing number of stools passed during first 48 hours significantly. Further our results favors that action of the drug starts immediately.…”

Section: Discussionsupporting

confidence: 63%

Racecadotril in Acute Watery Diarrhea in Children

Singh¹,

Yadav²,

Nanda³

2016

jemds

View full text Add to dashboard Cite

BACKGROUNDHypersecretory state of gut epithelium induced by toxins secreted by microorganisms is the main mechanism of fluid loss in diarrheal illness. Enkephalins (Endogenous Opioids) secreted by gut epithelium have marked pro-absorptive activity and are inactivated by enzyme enkephalinase. Racecadotril, the study drug act by augmenting the levels of enkephalins by inactivating enzyme enkephalinase thus leading to increased intestinal absorption.

show abstract

Section: Discussionsupporting

confidence: 63%

Racecadotril in Acute Watery Diarrhea in Children

Singh¹,

Yadav²,

Nanda³

2016

jemds

View full text Add to dashboard Cite

show abstract

“…Therefore, several efforts have been made to search for promising drugs that could be used to treat cholera more efficiently. These methods include inhibitors of cholera toxin receptor binding (Pickens et al, 2004), 5-hydroxytryptamine receptor antagonists (Mourad et al, 1995;Turvill and Farthing, 1997), somatostatin receptor agonists (Farthing, 1996), enkephalinase inhibitors (Cézard et al, 2001), and CFTR inhibitors (Muanprasat et al, 2004(Muanprasat et al, , 2007. Several natural products isolated from plants have also been used as sources of pharmaceuticals and as ingredients of traditional medicines (Phillipson, 1994).…”

mentioning

confidence: 99%

A Natural Plant-Derived Dihydroisosteviol Prevents Cholera Toxin-Induced Intestinal Fluid Secretion

Pariwat

Homvisasevongsa²,

Muanprasat³

et al. 2007

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Stevioside and its major metabolite, steviol, have been reported to affect ion transport in many types of tissues, such as the kidney, pancreas, and intestine. The effect of stevioside, steviol, and its analogs on intestinal Cl Ϫ secretion was investigated in a human T84 epithelial cell line. Short-circuit current measurements showed that steviol and analogs isosteviol, dihydroisosteviol, and isosteviol 16-oxime inhibited in a dosedependent manner forskolin-induced Cl Ϫ secretion with IC 50 values of 101, 100, 9.6, and 50 M, respectively, whereas the parent compound stevioside had no effect. Apical Cl Ϫ current measurement indicated that dihydroisosteviol targeted the cystic fibrosis transmembrane regulator (CFTR). The inhibitory action of dihydroisosteviol was reversible and was not associated with changes in the intracellular cAMP level. In addition, dihydroisosteviol did not affect calcium-activated chloride secretion and T84 cell viability. In vivo studies using a mouse closed-loop model of cholera toxin-induced intestinal fluid secretion showed that intraluminal injection of 50 M dihydroisosteviol reduced intestinal fluid secretion by 88.2% without altering fluid absorption. These results indicate that dihydroisosteviol and similar compounds could be a new class of CFTR inhibitors that may be useful for further development as antidiarrheal agents.

show abstract

“…There was no difference between racecadotril and placebo in respect of side effects, particularly constipation which often accompanied antidiarrhoeal activity of mu-opioid receptor antagonists. Cezard et al 24 also compared in their study racecadotril with placebo in respect to efficacy and tolerability. It was found that racecadotril was as tolerable as placebo with no significant side effects.…”

Section: Discussionmentioning

confidence: 99%

Tolerability of Racecadotril in Acute Watery Diarrhoea in Children

Singh¹,

Yadav²,

Nanda³

2016

jemds

View full text Add to dashboard Cite

BACKGROUNDAcute diarrhoea remains a major cause of mortality and morbidity in children due to dehydration, dyselectrolytemia and nutrient loss. Racecadotril is found to be effective in reducing the stool output in acute watery diarrhoea in children through its potent antisecretory effect mediated by enkephalinase inhibition in basolateral membrane of enterocytes and promoting selective chloride absorption through delta receptors and may prove to be beneficial in complications associated with acute watery diarrhoea.

show abstract

Efficacy and tolerability of racecadotril in acute diarrhea in children

Cited by 105 publications

References 20 publications

Racecadotril in Acute Watery Diarrhea in Children

Racecadotril in Acute Watery Diarrhea in Children

A Natural Plant-Derived Dihydroisosteviol Prevents Cholera Toxin-Induced Intestinal Fluid Secretion

Tolerability of Racecadotril in Acute Watery Diarrhoea in Children

Contact Info

Product

Resources

About