Efficacy and tolerance: comparative studies with brotizolam and flunitrazepam.

Goetzke, Edda; Findeisen, Peter; Welbers, Inés B.

doi:10.1111/j.1365-2125.1983.tb02316.x

Cited by 9 publications

(2 citation statements)

References 6 publications

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“…For general background to applications of benzodiazepines, see: Ahmed et al (1983); Bird (1996); Di Braccio et al (1990Braccio et al ( , 2001; Goetzke et al (1983); Kavita et al (1988); Sieghart & Schuster (1984); Wolff (1996). For examples of benzodiazepines used as medicine, see: Wolff (1996).…”

Section: Related Literaturementioning

confidence: 99%

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4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one

et al. 2011

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4-Phenyl-1H-1,5-benzodiazepin-2(3H)-one reacts in the presence of a concentrated aqueous solution of sodium hydroxide and a quaternary ammonium salt (as catalyst) in benzene (phase transfer catalysis) with propargyl bromide, affording the title benzodiazepine derivative, C18H14N2O. In the molecule, the mean plane of the propargyl substituent is almost perpendicular with that of the amide group [dihedral angle = 87.81 (8)°]. In the crystal, the molecules are linked by C—H⋯O and C—H⋯N interactions.

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Section: Related Literaturementioning

confidence: 99%

“…(Bird, 1996;Wolff, 1996), as they show antiviral (Di Braccio et al, 2001), analgesic (Di Braccio et al, 1990), and antipsychotic (Kavita et al, 1988) activities. These compounds are used worldwide as anticonvulsant agents (Sieghart & Schuster, 1984) or as sedative or hypnotics (Goetzke et al, 1983;Ahmed et al, 1983).…”

Section: Data Collectionmentioning

confidence: 99%

4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one

et al. 2011

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Sedative‐Hypnotics

Vida¹,

Yevich

2003

Burger's Medicinal Chemistry and Drug Discovery

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This chapter focuses on sedative‐hypnotic drugs that are sued to alleviate the condition of sleep disturbances. One‐third of our life is spent in sleep; the lack, of which, can cause serious physical, social, and psychological problems. This chapter describes the features of an ideal hypnotic drug and provides a classification of sedative‐hypnotic drugs currently in use. These include the barbiturates, benzodiazepines, halogenated sedative‐hypnotics, heterocyclic sedative‐hypnotics, antihistamines, and other sedative‐hypnotics. Individual members of all of these classes of drugs are discussed in detail. The chapter also describes the physiology of sleep and the sleep cycle, including the nonrapid eye movement and rapid eye movement sleep. A list of neurotransmitters and nonhypnotic drugs that have a direct and indirect action on the sleep cycle are provided. The pharmacology including the evaluation of sedative‐hypnotics are also given. The chapter refers to the discovery of one of the most frequently prescribed hypnotic drugs, Zolpidem. The chapter also examines structure‐activity relationships, recent developments, things to come, and available websites.

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Benzodiazepines and related drugs for insomnia in palliative care

Hirst¹,

Sloan

2001

Cochrane Database of Systematic Reviews

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Efficacy and tolerance: comparative studies with brotizolam and flunitrazepam.

Cited by 9 publications

References 6 publications

4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one

4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one

Sedative‐Hypnotics

Benzodiazepines and related drugs for insomnia in palliative care

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