Efficacy and tolerance of diclofenac sodium 0.1%, flurbiprofen 0.03%, and indomethacin 1.0% in controlling postoperative inflammation

Diestelhorst, Michael; Schmidl, Bernhard; Konen, Wolfgang; Mester, U; Raj, Palaniswamy Sunder

doi:10.1016/s0886-3350(96)80163-5

Cited by 43 publications

(22 citation statements)

References 17 publications

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“…It was also reported that preservatives may suppress the antiinflammatory efficacy of diclofenac (Yasuda et al 2012). Flurbiprofen and indomethacin were less effective than diclofenac (Diestelhorst et al 1996). Taken together, our results support the earlier findings that nepafenac and diclofenac are comparable in efficacy, and that the choice between them should be made based on other factors, such as tolerability, availability and price.…”

Section: Discussionsupporting

confidence: 89%

Postoperative management in cataract surgery: nepafenac and preservative‐free diclofenac compared

Ylinen

Taipale

Lindholm

et al. 2018

Acta Ophthalmologica

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Purpose: Current cataract surgery guidelines recommend routine use of topical nonsteroidal anti-inflammatory drugs (NSAIDs) in preventing pseudophakic cystoid macular oedema (PCME). Here, we compare the clinical efficacy and tolerability of two potent NSAIDs, nepafenac and preservative-free diclofenac following cataract surgery. Methods: Randomized, double-blind, prospective single-centre study. Ninety-six eyes of 95 patients undergoing routine cataract surgery were randomized 1:1 either to nepafenac (Nevanac, 1 mg/ml) or diclofenac (Dicloabak, 1 mg/ml) for 3 weeks. Seventy-three patients accounting for 73 eyes completed the entire follow-up. Aqueous flare and central retinal thickness (CRT) analysis were conducted preoperatively and at control visits 28 days and 3 months after surgery. A structured home questionnaire and interview were used to record any adverse effects of the topical medications, subjective visual recovery and the dispenser's ease of use. Results: No differences were observed between the groups for aqueous flare, CRT, speed of recovery or visual acuity gain. Seven patients (16%) on nepafenac and 20 patients (48%) on preservative-free diclofenac reported symptoms related to topical use of NSAID medications (p = 0.001). Conclusion: No differences in clinical efficacy were found between potent NSAIDs, while tolerability might be an issue.

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Section: Discussionsupporting

confidence: 89%

Postoperative management in cataract surgery: nepafenac and preservative‐free diclofenac compared

Ylinen

Taipale

Lindholm

et al. 2018

Acta Ophthalmologica

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“…Neither drug had any effect on IOP and no medication-related complications were observed in either treatment group [31]. Very similar findings were obtained in two other studies: diclofenac and ketorolac were equally as effective and safe [29,34].…”

Section: Conjunctival Inflammation ‡supporting

confidence: 81%

“…In a double-masked study in 117 patients undergoing phacoemulsification and IOL implantation, diclofenac was equally as effective as indomethacin, and more effective than flurbiprofen, at reducing anterior chamber flare. Furthermore, patients in the diclofenac group had significantly less burning and stinging than those in the flurbiprofen and indomethacin groups [31]. The result was supported by a study in 65 eyes that showed diclofenac to be a more effective anti-inflammatory than flurbiprofen when both treatments were combined with prednisolone [32].…”

Section: Prevention Of Postoperative Inflammation Following Cataract mentioning

confidence: 80%

Diclofenac sodium 0.1% ophthalmic solution: update on pharmacodynamics, clinical interest and safety profile

Bodaghi

2008

Expert Review of Ophthalmology

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Diclofenac sodium 0.1% ophthalmic solution has a long, well-proven track record as a potent, efficacious, topical, ocular anti-inflammatory agent, especially in the control of miosis during surgery, postsurgical inflammation of the anterior segment, cystoid macular edema and inflammation owing to noninfectious conjunctivitis such as allergic conjunctivitis. Owing to its analgesic properties, it is also widely used for short-duration treatment in pain associated with photorefractive keratectomy and corneal erosion. Therefore, it has been approved by health authorities for a wide range of indications, depending on each country. It has been shown to be at least as effective as other nonsteroidal anti-inflammatory drugs and corticosteroids. Diclofenac is a well-tolerated product and the few serious corneal adverse events that do occur could be avoided by good prescriptive practice and careful follow-up of patients at-risk. This review summarizes the available data on pharmacokinetics and pharmacodynamics, as well as the efficacy, safety and regulatory aspects related to diclofenac.

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“…aspirin, indomethacin, ibuprofen, naproxen, and diclofenac, which is effectively used in the treatment of rheumatoid arthritis [2]. FP is also indicated for the management of vernal keratoconjunctivitis [3], post-operative ocular inflammation [4], herpetic stromal keratitis [5], excimer laser photorefractive keratectomy [6] and ocular gingivitis [7]. Recent reports suggest potential topical and systemic use of FP in inhibition of colon tumor [8], pain management after foot surgery [9] and peridontal surgery [10].…”

Section: Introductionmentioning

confidence: 99%

Cloud point extraction-HPLC method for determination and pharmacokinetic study of flurbiprofen in rat plasma after oral and transdermal administration

Han

Yin

Shi

et al. 2008

Journal of Chromatography B

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Efficacy and tolerance of diclofenac sodium 0.1%, flurbiprofen 0.03%, and indomethacin 1.0% in controlling postoperative inflammation

Cited by 43 publications

References 17 publications

Postoperative management in cataract surgery: nepafenac and preservative‐free diclofenac compared

Postoperative management in cataract surgery: nepafenac and preservative‐free diclofenac compared

Diclofenac sodium 0.1% ophthalmic solution: update on pharmacodynamics, clinical interest and safety profile

Cloud point extraction-HPLC method for determination and pharmacokinetic study of flurbiprofen in rat plasma after oral and transdermal administration

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