Efficacy and toxicological evaluation of Coccinia grandis (Cucurbitaceae) extract in male Wistar rats

Attanayake, Anoja Priyadarshani; Jayatilaka, Kamani Ayoma Perera Wijewardana; Pathirana, Chitra; Mudduwa, Lakmini

doi:10.1016/s2222-1808(13)60101-2

Cited by 27 publications

(21 citation statements)

References 16 publications

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“…However, the administration of the selected plant extracts significantly increased the concentrations of C-peptide and insulin indicating their potent antihyperglycemic activity in diabetic rats. The results are in accordance with our previously published data on investigation of detailed antidiabetic mechanisms of the selected extracts in streptozotocin induced diabetic rats [13,15,16,34,35]. In the present study, alloxan induced diabetic rats had an alteration in the lipid profile at the end of the study period.…”

Section: Discussionsupporting

confidence: 93%

Biochemical and Histological Evaluation of Three Selected Medicinal Plant Extracts of Sri Lankan Origin on Dyslipidemia and Oxidative Stress in Alloxan Induced Diabetic Rats

et al. 2018

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The objective of the present study was to investigate the effect of refluxed aqueous extracts of Gmelina arborea, Spondias pinnata, and Coccinia grandis on atherogenicity and oxidative stress in rats with chemically induced type 1 diabetes mellitus. Alloxan monohydrate (150 mg/kg, intraperitoneal) was used to induce diabetes to Wistar rats. Thereafter, diabetic rats (n=6 per group) were treated with the three selected plant extracts at their optimum effective therapeutic doses and glibenclamide (0.50 mg/kg, positive control) for 30 days. Administration of the three extracts in diabetic rats exhibited antihyperglycemic, antiatherogenic, and antioxidant effects in diabetic rats on the 30th day of the study. The atherogenic and coronary risk indices were also reduced in support of the antiatherogenic effects. The results of the study revealed that the bark extracts of G. arborea, S. pinnata, and leaf extract of C. grandis exerted beneficial effects against dyslipidemia, atherogenicity, and oxidative stress in alloxan induced diabetic rats. The selected plant extracts would be beneficial for the development of food supplements targeting main complications associated with diabetes.

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Section: Discussionsupporting

confidence: 93%

Biochemical and Histological Evaluation of Three Selected Medicinal Plant Extracts of Sri Lankan Origin on Dyslipidemia and Oxidative Stress in Alloxan Induced Diabetic Rats

et al. 2018

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“…Reduction in body weight is known to be one of the most common indices to understand the toxicity profile of drugs. 33 Minor insignificant changes in body weight were observed throughout the treatment period. Any changes in food intake or water drinking pattern indicate a toxic impact on or abnormality in metabolism.…”

Section: Discussionmentioning

confidence: 96%

Phytochemical Screening and Toxicological Evaluation of <i>Sargassum wightii</i> Greville in Wistar Rats

RAMU¹,

MURALI²,

Anbu³

2019

tjps

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Bu çalışma, Sargassum wightii'nin farklı ekstrelerinde bulunan fitokimyasalları tanımlamak ve etanol ekstresinin toksisitesini değerlendirmek için yapılmıştır. Gereç ve Yöntemler: S. wightii'den total etanol ekstraksiyonu ve ardışık çözücü ekstraksiyonu yapılarak ekstreler üzerinde ön fitokimyasal tarama yapılmıştır. S. wightii'nin etanol ekstresinin (ESW) akut toksisitesi araştırılmıştır. ESW'nin subkronik toksisitesi, 100, 200 ve 400 mg/kg'lik dozlarla test edilmiştir. Hayvanlar, vücut ağırlığındaki ve yiyecek ve su alımındaki değişiklikler için gözlenmiştir. Çalışmanın sonunda, hayati organların relatif ağırlıkları, ardından histopatolojik incelemeler yapılmıştır. Çeşitli hematolojik ve biyokimyasal değerlendirmeler de yapılmıştır. Bulgular: S. wightii'nin fitokimyasal taraması, alkaloitler, karbonhidratlar, glikozitler, fenolik bileşikler ve tanenlerin varlığını ortaya koymuştur. ESW, akut toksisite çalışmasında mortalite veya terminal öncesi ölüme neden olmamıştır. Hayvanlar, vücut ağırlığındaki ve yem ve su tüketimindeki değişiklikler yönünden gözlenmiştir. Çalışmanın sonunda, hayati organların (beyin hariç) relatif ağırlıkları, yem ve su tüketiminde kontrol grubuna kıyasla anlamlı farklılıklar bulunamamıştır. Histopatolojik incelemede patolojik lezyonların olmadığını gösteren normal bir yapı izlenmiştir. Hematolojik ve biyokimyasal parametreler, yararlı olduğu düşünülen glukoz ve kolesterol seviyelerinde azalma haricinde, kontrol grubu ile de karşılaştırılabilir düzeyde bulunmuştur. Sonuç: S. wightii'de çeşitli fitokimyasalların varlığı, farklı hastalıkların tedavisi için potansiyel bir kaynak olabileceğinin kanıtıdır. ESW ile tedaviden sonra önemli bir toksik etki gözlenmemiştir. Bu nedenle, güvenli olduğu ve uzun süreli tedavide kullanılabilirliği önerilmiştir. Anahtar kelimeler: Sargassum wightii, fitokimyasal tarama, akut toksisite, subkronik toksiste Objectives: The present study was conducted to identify the phytoconstituents present in different extracts of Sargassum wightii and to assess the toxicity of its ethanol extract. Materials and Methods: Successive solvent extraction and total ethanol extraction of S. wightii were performed and preliminary phytochemical screening was carried out. The acute toxicity of ethanol extract of S. wightii (ESW) was studied. The subchronic toxicity of ESW was tested with doses of 100, 200, and 400 mg/kg. The animals were observed for changes in body weight and food and water intake. At the end of the study, the relative weights of vital organs were noted, followed by histopathological examinations. Various hematological and biochemical estimations were also carried out. Results: Phytochemical screening of S. wightii revealed the presence of alkaloids, carbohydrates, glycosides, phenolic compounds, and tannins. ESW did not induce any mortality or pre-terminal death in the acute toxicity study. There were no significant differences in body weight, relative weight of vital organs (except the brain), or food or water intake compared to the control group. The histopatho...

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“…The non-significant differences in body weight of animals taken on weekly basis in the present study indicates the normal physiology of growth with proportionate food and water intake at the dose of 100, 200 and 400 mg/kg. Any significant changes in food and water intake indicates the negative impact of test drug on the metabolism [ 38 ]. Non-significant differences in food and water intake indicate that fucoidan was safe on long term administration and did not induce any alteration to metabolic system.…”

Section: Discussionmentioning

confidence: 99%

Toxicological evaluation of Sargassum Wightii greville derived fucoidan in wistar rats: Haematological, biochemical and histopathological evidences

et al. 2020

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Efficacy and toxicological evaluation of Coccinia grandis (Cucurbitaceae) extract in male Wistar rats

Cited by 27 publications

References 16 publications

Biochemical and Histological Evaluation of Three Selected Medicinal Plant Extracts of Sri Lankan Origin on Dyslipidemia and Oxidative Stress in Alloxan Induced Diabetic Rats

Biochemical and Histological Evaluation of Three Selected Medicinal Plant Extracts of Sri Lankan Origin on Dyslipidemia and Oxidative Stress in Alloxan Induced Diabetic Rats

Phytochemical Screening and Toxicological Evaluation of <i>Sargassum wightii</i> Greville in Wistar Rats

Toxicological evaluation of Sargassum Wightii greville derived fucoidan in wistar rats: Haematological, biochemical and histopathological evidences

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