Toxicological evaluation of Sargassum Wightii greville derived fucoidan in wistar rats: Haematological, biochemical and histopathological evidences

Ramu, Sathiya; Murali, Anita; Narasimhaiah, Geetha; Anbu, J.

doi:10.1016/j.toxrep.2020.07.009

Cited by 16 publications

(6 citation statements)

References 37 publications

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“…Similar to these findings, orally administered neonicotinoid insecticide imidacloprid caused significant elevations in the leukocyte count (WBC) and decreases in the erythrocyte count (RBC), HGB level, and erythrocyte sedimentation rate (ESR) in mice [32] whereas acetamiprid decreased total leukocyte count (TLC), HGB concentration, HCT value and total erythrocyte count (TEC), as well as caused variations in MCV, MCHC and MCH in mice [18]. Studies have reported that fucoidan is a very safe molecule that does not cause toxic effects in mammals at high doses [33][34][35]. Furthermore, fucoidan does not have toxic effects on hematological parameters at low doses in rats (50-150 mg/kg) [36].…”

Section: Discussionmentioning

confidence: 99%

Fucoidan Protects against Acute Sulfoxaflor-Induced Hematological/Biochemical Alterations and Oxidative Stress in Male Mice

2021

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Fucoidan is a sulfated polysaccharide which can be found among a number of macroalgea species. It has a broad spectrum of biological activities including anti-oxidant, anti-tumor, immunoregulation, anti-viral and anti-coagulant. The current study was performed to investigate possible protective effects of fucoidan for sulfoxaflor-induced hematological/biochemical alterations and oxidative stress in the blood of male Swiss albino mice. For this purpose, sulfoxaflor was administered at a dose of 15 mg/kg/day (1/50 oral LD50), and fucoidan was administered at a dose of 50 mg/kg/day by oral gavage alone and combined for 24 h and 7 days. Hematological parameters (RBC, HGB, HCT, MCV, MCH, MCHC, Plt, WBC, Neu, Lym and Mon), serum biochemical parameters (AST, ALT, GGT, LDH, BUN, Cre and TBil), and serum oxidative stress/antioxidant markers (8-OHdG, MDA, POC and GSH) were analyzed. The results indicated that sulfoxaflor altered hematological and biochemical parameters and caused oxidative stress in mice; fucoidan ameliorated some hematological and biochemical parameters and exhibited a protective role as an antioxidant against sulfoxaflor-induced oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Fucoidan Protects against Acute Sulfoxaflor-Induced Hematological/Biochemical Alterations and Oxidative Stress in Male Mice

2021

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“…Kim et al likewise observed that an oral gavage of fucoidan (2000 mg/kg/day) did not induce cytotoxicity or genotoxicity in mice [53]. Also, acute and subacute toxicity studies involving the oral administration of 2000 mg/kg of fucoidan revealed no adverse reactions, mortality, or alterations in physiological parameters in mice over a 28-day period [214]. The safety of fucoidan is further revealed in another study involving the oral administration of fucoidan (up to 1000 mg/kg) for 14 days in Sprague-Dawley rats [215].…”

Section: Toxicity Studiesmentioning

confidence: 95%

Fucoidan’s Molecular Targets: A Comprehensive Review of Its Unique and Multiple Targets Accounting for Promising Bioactivities Supported by In Silico Studies

Zayed,

Al-Saedi,

Mensah

et al. 2023

Marine Drugs

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Fucoidan is a class of multifunctional polysaccharides derived from marine organisms. Its unique and diversified physicochemical and chemical properties have qualified them for potential and promising pharmacological uses in human diseases, including inflammation, tumors, immunity disorders, kidney diseases, and diabetes. Physicochemical and chemical properties are the main contributors to these bioactivities. The previous literature has attributed such activities to its ability to target key enzymes and receptors involved in potential disease pathways, either directly or indirectly, where the anionic sulfate ester groups are mainly involved in these interactions. These findings also confirm the advantageous pharmacological uses of sulfated versus non-sulfated polysaccharides. The current review shall highlight the molecular targets of fucoidans, especially enzymes, and the subsequent responses via either the upregulation or downregulation of mediators’ expression in various tissue abnormalities. In addition, in silico studies will be applied to support the previous findings and show the significant contributors. The current review may help in understanding the molecular mechanisms of fucoidan. Also, the findings of this review may be utilized in the design of specific oligomers inspired by fucoidan with the purpose of treating life-threatening human diseases effectively.

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“…Especially in the aspect of antitumor activity, many studies have reported the prominent effect of fucoidan, including in prostate cancers (Rui, Pan, Shao, & Xu, 2017), breast cancers (Zhang et al, 2016), liver cancers (Wu et al, 2020), colorectal cancers (Bai et al, 2020), and ovarian cancers (Liu, Yang, Peng, Li, & Zhu, 2020). And it is worth noting that fucoidan is characterized by high safety and nontoxic side effects, and its oral safety has been confirmed in animal and clinical studies (Ramu, Murali, Narasimhaiah, & Jayaraman, 2020). Furthermore, fucoidan has been widely studied in different models for autophagy, and results demonstrated that it could participate in the regulation of autophagy (Cheng et al, 2020;Guo et al, 2016;Zhang et al, 2020).…”

Section: Introductionmentioning

confidence: 98%

Inhibition of fucoidan on breast cancer cells and potential enhancement of their sensitivity to chemotherapy by regulating autophagy

Zhang

Xue

Wang

et al. 2021

Phytotherapy Research

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Fucoidan is a marine‐origin sulfated polysaccharide that has gained attention for its anticancer activities. However, the inhibitory effect of fucoidan on breast cancers by regulating autophagy and its mechanism are not clear, and the chemotherapeutic sensitization of fucoidan is largely unknown. In the present study, the anticancer potential of fucoidan was revealed in MCF‐7 and MDA‐MB‐231 cells. Additionally, we also studied the chemotherapeutic sensitization of fucoidan by combining chemotherapeutic drugs doxorubicin (ADM) and cisplatin (DDP) with fucoidan on breast cancer cells. In the two kinds of human breast cancer cells, cell viability was determined by 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) assay. Apoptosis was examined with flow cytometry. Transfection assay was used to examine autophagy flow. Western blot was used to examine the expressions of related proteins. Results suggested that fucoidan could induce autophagy and might enhance the sensitivity of breast cancer cells to chemotherapeutic drugs. Mechanistically, fucoidan induced autophagy in breast cancer cells by down‐regulating m‐TOR/p70S6K/TFEB pathway. In conclusion, our research revealed that fucoidan could induce autophagy of breast cancer cells by mediating m‐TOR/p70S6K/TFEB pathway, thus inhibiting tumor development. Furthermore, fucoidan might enhance the sensitivity of breast cancer cells to ADM and DDP, and this enhancement was related to autophagy.

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Toxicological evaluation of Sargassum Wightii greville derived fucoidan in wistar rats: Haematological, biochemical and histopathological evidences

Abstract: Graphical abstract

Cited by 16 publications

References 37 publications

Fucoidan Protects against Acute Sulfoxaflor-Induced Hematological/Biochemical Alterations and Oxidative Stress in Male Mice

Fucoidan Protects against Acute Sulfoxaflor-Induced Hematological/Biochemical Alterations and Oxidative Stress in Male Mice

Fucoidan’s Molecular Targets: A Comprehensive Review of Its Unique and Multiple Targets Accounting for Promising Bioactivities Supported by In Silico Studies

Inhibition of fucoidan on breast cancer cells and potential enhancement of their sensitivity to chemotherapy by regulating autophagy

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