Efficacy of 2% metronidazole gel in moderate acne vulgaris

Abstract

Background:Acne vulgaris is an inflammatory disease of the pilosebaceous units. Various systemic and topical options are available for its treatment.Aims:This study aimed to evaluate the efficacy of 2% metronidazole gel in acne vulgaris.Materials and Methods:Double-blind, randomized, placebo-controlled, split-face clinical trial. Seventy young adults with moderate acne vulgaris received 2% metronidazole gel on the right side of their face and placebo on the left side of their face twice daily for 8 weeks. The number of inflamed and noninflamed facial lesions and side effects of treatment were documented on weeks 1, 2, 4, and 8. The patients’ overall satisfaction was recorded at the end of the study. For statistical analysis we used the repeated-measures analysis, the chi-square test, Fisher's exact test, and the independent-samples t-test as appropriate.Results:Counts of inflamed and noninflamed facial lesions were comparable between the two sides at baseline. The number of the lesions was significantly lower on the metronidazole-treated side at all follow-up visits. Erythema and oily face decreased by 85.7% and 87.1%, respectively, on the metronidazole-treated side. Mild burning sensation and dryness on the metronidazole-treated side was reported by 3.4% and 22.9% of the patients, respectively. Eighty-eight percent of the patients were satisfied with the results of treatment on the metronidazole-treated side.Conclusions:Metronidazole gel (2%) is an effective, safe, and well-tolerated topical medication for moderate acne vulgaris.

Identifying and appraising patient‐reported outcome measures on treatment satisfaction in acne: a systematic review*

“…Studies that only used the PROM as an outcome measurement instrument were excluded, but study details were tabulated, per protocol. We identified 188 studies that reported treatment satisfaction as an outcome: 91 on treatment of acne 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 ,…”

Comparative antimicrobial efficacy of selected root canal irrigants on commonly isolated microorganisms in endodontic infection

“…Similarly, Effat Khodeinae et al . [23] demonstrated that 2% metronidazole showed adequate efficacy against P. acnes while evaluating the efficacy of 2% metronidazole gel against acne vulgaris. In contrast to the above results, few studies reveal no effect of metronidazole against P. acnes .…”

The rate and pattern of Bcl-2 and cytokeratin 15 expression in trichoepithelioma and nodular basal cell carcinoma: A comparative study

“…However, it was previously shown that the basal layer of normal epidermis is usually negative for CK15. [11] Finally, like in any other dermatological pathology, the role of possible confounding factors such the skin type[3435] and age of the patients[36] should be investigated in further studies…”