Efficacy of 595nm pulsed dye laser therapy for Mibelli angiokeratoma

Su, Qianya; Lin, Tong; Wu, Qiuju; Wu, Yongkai; Guo, Lanwei; Ge, Yiping

doi:10.3109/14764172.2014.1003242

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…The largest study investigating PDL treatment (fluence 12–13.5 J/cm 2 , spot size 7 mm, pulse duration 10 ms, and ice pack cooling) of angiokeratomas was conducted by Su et al (Su et al, ) and involved 50 patients with angiokeratoma of Mibelli. There was significant improvement (defined as 60–100% clearance) in 80% of patients and 30% showed complete resolution (defined as 95–100% clearance).…”

Section: Resultsmentioning

confidence: 99%

“…An advantage of using the PDL to treat genital angiokeratomas is that it requires minimal anesthesia, and topical agents are often sufficient (Lapidoth et al, ; Oni & Mahaffey, ). Reported adverse effects are modest and include bleeding (lasting minutes) (Lapidoth et al, ), purpura, and edema (lasting 12 hours to several days) (Su et al, ). Permanent side effects may include skin pigment and texture changes (Baumgartner, Simaljakova, & Babal, ), but lower fluence settings can decrease the risk of post‐treatment dyspigmentation (Campbell, Dimitropoulos, & Brown, ).…”

Section: Resultsmentioning

confidence: 99%

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Laser treatment of cutaneous angiokeratomas: A systematic review

Nguyen

Chapman

Korta

et al. 2017

Dermatologic Therapy

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Angiokeratomas can present therapeutic challenges, especially in cases of extensive lesions, where traditional surgical methods carry high risks of scarring and hemorrhage. Argon, pulsed dye (PDL), neodymium-doped yttrium aluminum garnet (Nd:YAG), copper vapor, potassium titanyl phosphate, carbon dioxide, and erbium-doped yttrium aluminum garnet (Er:YAG) lasers have emerged as alternative options. To review the use and efficacy of lasers in treating angiokeratomas. A PubMed search identified randomized clinical trials, cohort studies, case series, and case reports involving laser treatment of cutaneous angiokeratomas. Twenty-five studies were included. Quality ratings were assigned using the Oxford Centre for Evidence-Based Medicine scheme. Several laser modalities are effective in treating multiple variants of angiokeratomas. Vascular lasers like PDL, Nd:YAG, and argon are the most studied and of these, PDL offers the safest side effect profile. Nd:YAG may be more effective for hyperkeratotic angiokeratomas. Combination treatment with multiple laser modalities has also demonstrated some success. Lasers are a promising treatment option for angiokeratomas, but current use is limited by the lack of treatment guidelines. There are limited high quality studies comparing laser treatments to each other and to non-laser options. Additional studies are needed to establish guidelines and to optimize laser parameters.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Laser treatment of cutaneous angiokeratomas: A systematic review

Nguyen

Chapman

Korta

et al. 2017

Dermatologic Therapy

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“…Several types of laser devices have been shown to be effective in the treatment of Mibelli's AK including pulsed dye laser (PDL), Nd:YAG laser, and sequential PDL-Nd:YAG laser [14,15] .…”

Section: Mibelli's Akmentioning

confidence: 99%

Differential Diagnoses of Angiokeratomas

2020

AJODRR

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Review Article AJODRR (2020) 3:34 DIFERENTIAL DIAGNOSES OF ANGIOKERATOMAS Angiokeratomas (AK) are probably the vascular lesions that induce more confusion in the literature. The most accepted classification of AK was performed by Imperial and Helwig [1] , and they divide these lesions into five classical types: Mibelli's AK, Fordyce's AK, corporis diffusum AK, circumscribed naeviforme AK and solitary or multiple adquired angiokeratomas. Nevertheless, in the clinical practice, is not unusual to see AK type lesions associated to different types of vascular anomalies, and these lesions have difficult handling. In ISSVA classification AKs have been included as vascular anomalies provisionally unclassified. We perform the differential diagnoses of AKs and according to clinical picture, histopathological aspect, immunohistochemical markers and radiological findings proposed to divide AKs mainly in two groups. Primary AKs are the classical types. The new inmunohistochemical findings suggest that these lesions might be included as mixed capillary-lymphatic malformations. Secondary AKs are related with different vascular anomalies, secondary to other process with lymphatic obstruction, related to drugs, or associated with no vascular lesions as lymphoid lesions. Different underlying vascular anomelies might be related with AKs including deep capillary-lymphatic malformations (CLM), venous-lymphatic malformations (VLM), capillary-lymphatic-venous malformations (CLVM) (Klippel-Trenaunauy Sd), deep lymphatic malformations (LM), venous malformations (VM) as hyperkeratotic venous malformation, cavenomatous cerebral malformations, traumatic arteriovenous fistula and eccrine angiokeratomatous hamartoma. Clinical aspect, radiological studies and histopathological examination might help to do a correct diagnosis of this heterogenous entity.

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