Efficacy of a hyaluronan derivative gel in postsurgical adhesion prevention in the presence of inadequate hemostasis

Iaco, Pierandrea De; Muzzupapa, Giuseppe; Bigon, E.; Pressato, Daniele; Donà, Massimo; Pavesio, Alessandra; Bovicelli, Luciano

doi:10.1067/msy.2001.115102

Cited by 40 publications

(37 citation statements)

References 9 publications

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“…The effi cacy of ACP gel in postsurgical adhesion prevention during bleeding or inadequate hemostasis was evaluated in a rabbit model [ 84 ] . Exudative abdominal bleeding (oozing model) and severe bleeding (bleeding model) were created on the uterine horn of rabbits.…”

Section: Hyaluronic Acid-based Materialsmentioning

confidence: 99%

Barriers to Prevent Tissue Adhesion

Suzuki

Ikada

2011

Biomaterials for Surgical Operation

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Adhesion often occurs after surgery, especially in abdominal, gynecological, and thoracic surgeries. It can cause serious postsurgical complications such as infertility, chronic pelvic pain, and diffi culties of extensive adhesiolysis in future surgery. Antiadhesive barriers have been developed to provide physical separation between the injured site and the adjacent tissues. Since physical separation is only required during the critical time of wound healing of the damaged area, bioabsorbable polymers have been found to be appropriate. A range of adhesion barriers are commercially available in the forms of solutions, gels, and sheets. Their characteristics and limitations are discussed in this chapter. Recent investigations are also described on newly developed devices that show promising performance such as ease of handling and more effective reduction of adhesion.

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Section: Hyaluronic Acid-based Materialsmentioning

confidence: 99%

Barriers to Prevent Tissue Adhesion

Suzuki

Ikada

2011

Biomaterials for Surgical Operation

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“…[10][11][12][13][14] This information suggests that a similar strategy could also be successfully applied to the prevention of adhesions in other types of surgical intervention including surgery of peripheral nerve lesions. Hyaloglide 1 may have dual effects in minimizing postsurgical adhesions by biological means as well as by acting as a reabsorbable barrier.…”

Section: Hyaloglidementioning

confidence: 99%

“…[7][8][9] A similar product has been shown to be effective in reducing adhesions in gynecologic and intraabdominal surgery in both experimental and clinical trials. [10][11][12][13][14] Moreover, Hyaloglide 1 has been shown to reduce postoperative perineural adhesions in animal models. 15,16 Altogether, these characteristics suggested that such a strategy could be applied successfully to the prevention of adhesions following peripheral nerve repair, with the added advantage of improved nerve regeneration.…”

mentioning

confidence: 99%

Clinical evaluation of a hyaluronan‐based gel following microsurgical reconstruction of peripheral nerves of the hand

Atzei

Calcagni

Breda³

et al. 2007

Microsurgery

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“…The percent encapsulation efficiency (%EE) and drug loading (%DL) were determined indirectly from the supernatant after ultra-centrifugation and appropriate dilution using a high-performance liquid chromatography (HPLC) assay (31). The formulation of HA-gel was based on hydration and internal cross-linking reaction of the native HA at the concentration of 2%w/v in water as previously reported (32).…”

Section: Formulation and Drug Loading Into Ha-nps And Ha-gelmentioning

confidence: 99%

Hyaluronidase-Sensitive Nanoparticle Templates for Triggered Release of HIV/AIDS Microbicide In Vitro

Agrahari

Zhang

et al. 2013

AAPS J

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Abstract. This study was designed to test the hypothesis that a triggered release of a topical microbicide (tenofovir) from hyaluronic acid nanoparticles (HA-NPs) can be achieved under the influence of hyaluronidase (HAase) enzyme. A fractional factorial experimental design was used to examine the factors [molar concentrations of adipic acid dihydrazide (X 1 ) and 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride (X 2 ), volume of acetone (X 3 ) and reaction time (X 4 )] influencing the responses, Y 1 ; particle mean diameter: PMD (nanometers: nm), Y 2 ; polydispersity index: PDI and Y 3 ; zeta (ζ) potential: (millivolts). The amide bond formation between HA and ADH after cross-linking was confirmed by FT-IR and 13 C-NMR analyses. These NPs were also characterized for cytotoxicity on a human vaginal epithelial cell line and L. crispatus. When formulated with factors X 1 ; 2.49 mM, X 2 ; 9.96 mM, X 3 ; 60 mL, X 4 ; 6 h, HA-NPs exhibited a spherical shape with PMD, PDI, ζ potential, encapsulation efficiency, and drug loading of 70.6±4.1 nm, 0.07±0.02, −38.2±2.8 mV, 51.8±2.4% w/w and 26.1±1.2% w/w, respectively, (n=3). Unlike for HA based gel, HAase significantly triggered the drug release and HA degradation from the NPs after 24 h (∼90% w/w and 65% w/w, respectively); whereas, in its absence, these values were ∼39% w/w and 26% w/w, respectively. The NPs were non-cytotoxic to human vaginal VK2/ E6E7, End1/E6E7 cells and Lactobacillus crispatus. These data highlight the potential of HAase-sensitive HA-NPs templates for the controlled and vaginal delivery of anti-HIV/AIDS microbicides.

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Efficacy of a hyaluronan derivative gel in postsurgical adhesion prevention in the presence of inadequate hemostasis

Cited by 40 publications

References 9 publications

Barriers to Prevent Tissue Adhesion

Barriers to Prevent Tissue Adhesion

Clinical evaluation of a hyaluronan‐based gel following microsurgical reconstruction of peripheral nerves of the hand

Hyaluronidase-Sensitive Nanoparticle Templates for Triggered Release of HIV/AIDS Microbicide In Vitro

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