Efficacy of a Mediterranean diet supplemented with fatty fish in ameliorating inflammation in paediatric asthma: a randomised controlled trial

Papamichael, Maria Michelle; Katsardis, Ch.; Lambert, Katrina A.; Tsoukalas, Dimitris; Koutsilieris, M.; Erbas, Bircan; Itsiopoulos, Catherine

doi:10.1111/jhn.12609

Cited by 46 publications

(40 citation statements)

References 52 publications

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“…Subjects with a higher O3I had a significantly lower range of maintenance ICS dose. A similar finding has been shown in a recent RCT by Papamichael et al [41], where children with asthma were prescribed a Mediterranean diet supplemented with two meals of 150 g cooked fatty fish per week for 6 months, compared to a control group following their normal diet. They found that while there was no difference between lung function, asthma control and quality of life scores, there was a significant reduction in medication use for children in the intervention group [41].…”

Section: Discussionsupporting

confidence: 85%

“…A similar finding has been shown in a recent RCT by Papamichael et al [41], where children with asthma were prescribed a Mediterranean diet supplemented with two meals of 150 g cooked fatty fish per week for 6 months, compared to a control group following their normal diet. They found that while there was no difference between lung function, asthma control and quality of life scores, there was a significant reduction in medication use for children in the intervention group [41]. In a study examining exercise-induced bronchoconstriction, n-3 PUFA supplementation (3200 mg EPA + 200 mg DHA for eight weeks) has also been demonstrated to reduce bronchodilator use in adults [42].…”

Section: Discussionsupporting

confidence: 85%

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Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study

et al. 2019

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Asthma is a chronic inflammatory airway disease, associated with systemic inflammation. Omega-3 polyunsaturated fatty acids (n-3 PUFA) have established anti-inflammatory effects, thus having potential as an adjunct therapy in asthma. This study aimed to compare erythrocyte n-3 PUFA in adults with (n = 255) and without (n = 137) asthma and determine the relationship between erythrocyte n-3 PUFA and clinical asthma outcomes. Subjects had blood collected, lung function measured and Juniper Asthma Control Questionnaire (ACQ) score calculated. Fatty acids were measured in erythrocyte membranes by gas chromatography, and the omega-3 index (O3I) was calculated (% eicosapentaenoic acid + % docosahexaenoic acid). O3I was similar in subjects with and without asthma (p = 0.089). A higher O3I was observed in subjects with controlled or partially controlled asthma (ACQ < 1.5) compared to subjects with uncontrolled asthma (ACQ ≥ 1.5) (6.0% (5.4–7.2) versus 5.6% (4.6–6.4) p = 0.033). Subjects with a high O3I (≥8%) had a lower maintenance dose of inhaled corticosteroids (ICS) compared to those with a low O3I (<8%) (1000 μg (400–1000) versus 1000 μg (500–2000) p = 0.019). This study demonstrates that a higher O3I is associated with better asthma control and with lower ICS dose, suggesting that a higher erythrocyte n-3 PUFA level may have a role in asthma management.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 85%

Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study

et al. 2019

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“…Traditional Mediterranean diet is the dietary pattern that has been linked to a number of metabolic and health benefits, including reduced mortality risk and lower incidence of cardiovascular disease[6, 7] and reducing airway inflammation in asthma[8]. The benefits of even short periods of adherence to Mediterranean diet on inflammatory markers have been shown[9] and the adipose tissue inflammatory response, measured by IL-6, MCP-1, leptin and adiponectin gene expression[10], can be modulated by a single meal.…”

Section: Introductionmentioning

confidence: 99%

What is the effect of a Mediterranean compared with a Fast Food meal on the exercise induced adipokine changes? A randomized cross-over clinical trial

et al. 2019

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Background Adipose tissue-derived adipokines are pro-inflammatory cytokines involved in metabolic-related diseases and can be influenced by diet and exercise. We aimed to compare the effect of a Mediterranean (MdM) compared with Fast Food (FFM) meal on the exercise induced adipokines changes. Methods In a double blinded cross over trial, 46 participants were randomly assigned to one of two standardized iso-energy pre-exercise meals: FFM or MdM-type. Three hours after each meal, participants completed a treadmill exercise test (EC). Serum adiponectin, resistin, PAI-1, lipocalin-2/NGAL and adipsin were determined by Luminex magnetic bead immunoassay. Wilcoxon signed rank test compared changes before/after meal and before/after EC and a linear mixed model evaluated the effect of meals on the adipokine response to exercise, adjusted for confounders. Results Thirty-nine participants (mean age of 25, with a standard deviation of 5 years) completed the trial (56% females). For both interventions, a significant reduction of adipsin after each meal and a significant increase of lipocalin, PAI-1, adipsin and resistin, after exercise was observed. When exercise was preceded by a MdM meal a higher increase in adipsin levels was seen. Conclusion Acute exercise induced an increase of circulatory levels of adipsin, resistin, lipocalin and PAI-1, but not adiponectin. A pre-exercise Mediterranean meal potentiated the increase of adipsin after the exercise test, which possibly relates to the immune regulatory role of adipsin. These changes suggest a cross-talk between the immune and metabolic immediate response to exercise and its modulation by the pre-exercise diet composition.

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“…However, a recent Randomized Control Trial, a supplementation of 150 g cooked fatty fish in two meals per week, showed a significant reduction of bronchial inflammation after a 6-month intervention. FeNO values reduced on 14.15 ppb in comparison to those that were not supplemented [40].…”

Section: Discussionmentioning

confidence: 85%

Dietary patterns and asthma among Peruvian children and adolescents

et al. 2020

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Background: Asthma is one of the conditions that contributes to the global burden of respiratory diseases and has been previously associated with diet intake. The goal of this study was to determine the relationship between diet, assessed by a developed score, and asthma in Peruvian children. Methods: This study was a cross sectional analysis nested within an unmatched case-control study of children in two peri-urban communities of Lima, Peru. We evaluated 767 children and adolescents (573 with asthma, 194 controls) between 9 and 19 years. Diet was assessed using a food frequency questionnaire (FFQ), with food groups classified as "healthy" or "unhealthy". Asthma control, Lung function and atopy were assessed by Asthma Control Test, Spirometry and InmunoCAP 250 test, respectively. Results: Mean age of participants was 13.8 years (SD 2.6). Mean diet score was 5 (SD 1.23; range 2-8). Healthy Diet Score was associated with asthma status [OR 0.83, 95% CI (0.72, 0.95), p = 0.009] in adjusted analysis. Thus, participants with higher HDS, had lower odds of asthma. In sensitivity analyses, when adjusting for atopy, results did not change significantly. [OR 0.85, 95% CI (0.72, 0.99); p = 0.04]. No association between the HDS and asthma control, FEV1, nor FeNO were observed. Atopy did not modify the association between diet and asthma outcomes. Conclusions: In our study cohort, better diet quality was associated with lower odds of asthma, but was not associated with asthma control. Diet modification may be a potential intervention to impact the increasing prevalence of this disease.

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Efficacy of a Mediterranean diet supplemented with fatty fish in ameliorating inflammation in paediatric asthma: a randomised controlled trial

Cited by 46 publications

References 52 publications

Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study

Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study

What is the effect of a Mediterranean compared with a Fast Food meal on the exercise induced adipokine changes? A randomized cross-over clinical trial

Dietary patterns and asthma among Peruvian children and adolescents

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