Efficacy of a new mouthrinse formulation on the reduction of oral malodour in vivo. A randomized, double-blind, placebo-controlled, 3 week clinical study

Abstract

The present study was conducted to assess the efficacy of a new mouthrinse formulation in reducing oral malodour compared to that of commercially available products containing chlorhexidine (CHX) and a negative control. 174 healthy volunteers, each with an organoleptic score of at least 2 and an H(2)S level as part of the volatile sulfur compounds (VSC) higher than 50 ppb, were divided into four groups. Participants were stratified according to their organoleptic ratings (OR). Group I: mouthrinse I (250 ppm F(-) from amine fluoride/stannous fluoride (ASF), 0.2% zinc lactate, oral malodour counteractives); group II: mouthrinse II (0.05% CHX, 0.05% cetylpyridinium chloride, 0.14% zinc lactate); group III: mouthrinse III (0.12% CHX); group IV: tap water. All groups were instructed to perform standardized oral hygiene measures and to apply the respective test rinse twice daily after tooth brushing. Malodour was assessed by organoleptic measurement and by VSC levels at baseline, day 1, day 7, day 14 and day 21 into the study. To evaluate discolouration of the teeth, the colour was assessed at baseline and final visit. The ASF mouthrinse showed superior efficacy as compared to the negative control. A significant reduction in OR and VSC readings was achieved after single application as well as after 7 and 21 days of continuous use. Between test groups I-III no statistically significant differences were found at any time point. There was also a trend towards fewer side effects caused by the ASF product compared to the products containing CHX. The newly developed mouthrinse product significantly reduces oral malodour in patients with increased values both in OR and in VSC.

The effect of mouthrinses on oral malodor: a systematic review

“…The optimal mouthrinses for oral malodor are thought to be antiseptic agents with proven, long-lasting efficacy in reducing organoleptic scores and VSC levels. Furthermore, these products should have little or no side effects because it may be necessary to use them over longer periods of time (48). A significant number of studies have investigated this issue over the last 30 years.…”

The effect of a tooth/tongue gel and mouthwash regimen on morning oral malodour

“…10 A possible explanation for the difference with the present finding may be in the method used for organoleptic scoring. The research group conducting these studies 9,11,12 used the same 6-point scale but positioned the study participants in a room adjacent to the room with the organoleptic judges. The participants exhaled through a hole, and on the opposite side of the dividing wall, the judges smelled and rated their breath.…”

“…Clinical trials evaluating morning oral malodour have shown that this mouthwash was effective compared to a negative control. 9,10 In addition, there is also a tooth/tongue gel available that contains the same ingredients as the commercially available mouthwash. This gel can be used in combination with a tongue cleaner.…”

Role of Stabilized Stannous Fluoride in Halitosis Prevention and Treatment – Literature Review

“…That is why this compound has been listed on the hazardous chemicals list. The counter-argument to the above-mentioned reports is recent, short-term in vivo research, led by Wigger-Alberti et al [20], who have investigated the effect of mouth rinses with active ingredients (see below) on the decrease in OR and VSC. The authors have used following formulas: I -containing SnF 2 with zinc lactate, II -containing chlorhexidine with cetylpyridinium chloride, III -containing chlorhexidine and IV -containing water.…”