Efficacy of a novel formulation of metaflumizone plus amitraz for the treatment of demodectic mange in dogs

Fourie, L.J.; Kok, D. J.; Plessis, A. du; Rugg, Douglas

doi:10.1016/j.vetpar.2007.08.047

Cited by 24 publications

(34 citation statements)

References 11 publications

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“…It is likely that self recovery in LD might be due to cooperative actions of CD8+ and CD4+ T cells against the mites. Conversely, generalized demodicosis is considered to be a severe disease requiring prolonged treatment, which is often difficult and potentially life-threatening (Fourie et al 2007). Compromised CD4+ T cells may not be complementary to CD8+ T cells, thus self recovery in GD may not be encountered.…”

Section: Discussionmentioning

confidence: 99%

Determination of CD4+ and CD8+ T cells in the peripheral blood of dogs with demodicosis

et al. 2010

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The aim of this study was to evaluate the CD4+/CD8+ ratio in peripheral blood of dogs with localized and generalized demodicosis. Sixteen dogs were examined, 8 with localized and 8 with generalized demodicosis, while 8 healthy dogs were used as controls. Peripheral blood was obtained and CD4+ and CD8+ T cells were determined by flow cytometry. Significantly higher numbers of CD8+ T cells and lower numbers of CD4+ T cells were found in dogs with generalized demodicosis compared to dogs with localized demodicosis and healthy controls. Significantly higher numbers of CD8+ T cells and lower numbers of CD4+ T cells were also found in dogs with localized demodicosis compared to healthy controls. The CD4+/CD8+ ratio was also found to be significantly lower in dogs with generalized demodicosis in comparison with dogs with localized demodicosis and healthy controls. It is concluded that significant alteration in the CD4+/CD8+ ratio may be implicated in the pathogenesis of generalized canine demodicosis.

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Section: Discussionmentioning

confidence: 99%

Determination of CD4+ and CD8+ T cells in the peripheral blood of dogs with demodicosis

et al. 2010

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“…Its efficacy had been evaluated in naturally infested dogs in a clinical study (Fourie and others 2007) but, in addition to the bad odour lasting for a while on the dogs and in the environment when applied indoors, a number of treated dogs developed a drug reaction (pemphigus-like syndrome) (Oberkirchner and others 2011). …”

Section: Treatmentmentioning

confidence: 99%

Treatment of canine demodicosis

Cerundolo¹

2016

In Practice

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Demodicosis is a common canine ectoparasitosis. Recognising the clinical presentation, identifying the parasite and choosing the most appropriate therapy are essential for the successful management of a patient. There are various acaricides and the recent advent of safer and more effective drugs has made the treatment of affected animals much easier than previously. This article aims to help veterinary practitioners choose the safest and most efficient therapy for canine demodicosis and focuses on the treatment options available in the UK.

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“…The disease is considered to be chronic and generalized when it persists for at least six months with involvement of no less than 50% of the dog's body or involvement of the four limbs. This form has been reported as being difficult to treat and the outcome is often frustrating (Paradis & Pagé 1998, Fourie et al 2007). Dogs 3, 5, 7, 9, 12, 15 and 18 (7/18) had been developing clinical signs of infestation for at least six months prior to being enrolled into the study and they presented the generalized form of demodicosis.…”

Section: Discussionmentioning

confidence: 99%

“…The success rate was defined as the percentage of dogs in each group that presented negative skin scraping tests (Fourie et al 2007). …”

Section: Methodsmentioning

confidence: 99%

Clinical and parasitological evaluation of pour-on fluazuron and ivermectin for treating canine demodicosis

2014

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RESUMO.-[Avaliação clínica e parasitológica do fluazuron e da ivermectina pour-on no tratamento da demodiciose canina.] O objetivo do presente estudo foi avaliar a eficácia do fluazuron e da ivermectina pour-on em diferentes protocolos terapêuticos no tratamento da demodiciose, através da quantificação de ácaros por raspados cutâneos e exames histológicos, além da avaliação dos cães. Foram avaliados 18 cães com raspados cutâneos positivos para o ácaro Demodex canis, divididos em três grupos. Todos os animais foram tratados a cada 14 dias, totalizando seis tratamentos em cada cão (Dias 0, 14, 28, 42, 56 e 70). No grupo 1 foi utilizado fluazuron 2,5% pour-on na dosagem de 20mg/kg; no grupo 2 foi empregado fluazuron 2,5% pour--on na dosagem de 20mg/kg associado a ivermectina 0,5% pour-on, na dosagem de 0,6mg/kg e, no grupo 3, somente ivermectina 0,5% pour-on 0,6mg/kg. The objective of the study was to evaluate the efficacy of pour-on formulations of fluazuron and ivermectin in different therapeutic protocols for treatment of demodicosis by means of quantifying mites with skin scraping, histological and clinical evaluation in dogs. Eighteen dogs with skin scrapings positive for Demodex canis were evaluated, divided into three groups. All the animals were treated every 14 days, completing 6 treatments for each animal (days 0, 14, 28, 42, 56 and 70). In group 1, pour-on 2.5% fluazuron was used at the dose of 20mg/kg; in the group 2 pour-on 2.5% fluazuron at a dose of 20 mg/kg in association with pour-on 0.5% ivermectin at the dose of 0.6mg/kg; and in group 3, pour-on 0.5% ivermectin alone was used, at the dose of 0.6mg/kg. The treatment was evaluated and monitored through skin scrapings and clinical follow-up of the lesions every 14 days for 84 days, and through histopathological examination at the end of each treatment protocol. The success rate was defined as the percentage of dogs in each group that had negative skin scrapings after the treatment: this was 16.67% for group 1, and 50% for groups 2 and 3. The reduction in mite counts reached effectiveness of 67.66%, 88.99% and 84.29% for groups 1, 2 and 3 respectively. The Wilcoxon test showed that there was a significant difference between the number of mites before and after treatment in groups 2 and 3. The histopathological examination revealed that only group 1 showed no significant difference in the intensity of infestation between days 0 and 84. Clinically, there was no significant difference between the evaluation before and after treatment in the three groups. Pour-on 2.5% fluazuron and pour-on 0.5% ivermectin were not effective for treating canine demodicosis, either in association or as single therapy, when applied every 14 days for a period of 70 days. Quantification of mites using skin scrapings and histological evaluation proved to be ineffective, either one as sole therapeutic evaluation parameters, for canine demodicosis.INDEX TERMS: Demodex canis, control, fluazuron, ivermectin, pour-on. 1095 Clinical and parasitological evaluation of pour-on fluazuro...

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Efficacy of a novel formulation of metaflumizone plus amitraz for the treatment of demodectic mange in dogs

Cited by 24 publications

References 11 publications

Determination of CD4+ and CD8+ T cells in the peripheral blood of dogs with demodicosis

Determination of CD4+ and CD8+ T cells in the peripheral blood of dogs with demodicosis

Treatment of canine demodicosis

Clinical and parasitological evaluation of pour-on fluazuron and ivermectin for treating canine demodicosis

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