Efficacy of a novel herbal formulation for weight loss demonstrated in a 16‐week randomized, double‐blind, placebo‐controlled clinical trial with healthy overweight adults

Dixit, Kashinath; Kamath, Dinesh; Alluri, KrishnaRaju Venkata; Davis, Barbara

doi:10.1111/dom.13443

Cited by 16 publications

(25 citation statements)

References 18 publications

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“…From day 29, the start of the supplementation phase, the rats received an oral gavage of 0.5% Carboxymethylcellulose Sodium (CMC) alone (G1 and G2) or combined with the selected doses of LI85008F (G3 and G4). The low dose of the herbal blend tested in the present study was approximately equivalent to the clinical dose of LI85008F [10,11].…”

Section: Animal Care and Experimental Designmentioning

confidence: 88%

“…Subsequently, two clinical studies have demonstrated that LI85008F supplementation significantly reduced body weight (BW), along with BMI in overweight and obese human subjects. LI85008F also improved the lipid profile and adiponectin level in serum, compared with the placebo [9][10][11]. Two exciting findings in the earlier clinical studies were enhanced intracellular fat breakdown in the LI85008F treated 3 T3-L1 fat cells, and increased serum adiponectin level in LI85008F supplemented participants.…”

Section: Introductionmentioning

confidence: 88%

“…The Taxonomy Division of Laila Impex R&D Centre, Vijayawada, India, preserved their voucher specimens. Earlier communications described the methods of individual extract preparation from the dried plant raw materials and phytochemical standardization of LI85008F formulation [9][10][11]. The final standardized product contains at least 7.0% total curcuminoids (Curcumin + Bisdemethoxycurcumin + Demethoxycurcumin), 0.1% Mahanine, and 0.2% Quercetin 3-O-glycoside.…”

Section: Study Materialsmentioning

confidence: 99%

“…LI85008F is an herbal extract combination composed of aqueous-ethanol extract of Moringa oleifera leaves, Murrya koenigii leaves, and Curcuma longa rhizomes extract standardized to not less than 95% total curcuminoids [9,10]. This composition showed synergy in inhibiting new adipocyte formation through the PPARγ dependent cell differentiation process in vitro and demonstrated that LI85008F significantly increased lipid breakdown in cultured fat cells [11].…”

Section: Introductionmentioning

confidence: 99%

“…Two exciting findings in the earlier clinical studies were enhanced intracellular fat breakdown in the LI85008F treated 3 T3-L1 fat cells, and increased serum adiponectin level in LI85008F supplemented participants. These observations prompted to postulate whether LI85008F might trigger thermogenic activity in the body [9][10][11]. Earlier animal studies have demonstrated that adiponectin increases energy expenditure via activation of thermogenesis in brown fat cells and suggest this hormone is an essential regulator of energy metabolism [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Combined extracts of Moringa oleifera, Murraya koeingii leaves, and Curcuma longa rhizome increases energy expenditure and controls obesity in high-fat diet-fed rats

et al. 2020

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Background: LI85008F is a proprietary combination of leaf extracts of Moringa oleifera, Murraya koeingii, and extract of Curcuma longa rhizome. This herbal extract combination is an effective weight loss supplement for overweight and obese subjects. The present study aimed to investigate the thermogenic potential of the LI85008F in high-fat diet (HFD)-induced obese Sprague Dawley rats. Methods: Seven rats received a regular diet (RD), and twenty-one rats received a high-fat diet (HFD) for 56 days. On day 28, the HFD-fed rats were randomized into three groups (n = 7). Starting from day 29 through day 56, one HFD-fed group received daily oral gavage of 0.5% Carboxymethylcellulose Sodium (CMC) alone (HFD), and the remaining two groups received 100 and 250 mg/kg LI85008F (LI85008F-100 and LI85008F-250, respectively). Body weight, fat mass, fat cell size, liver weight, liver triglyceride were measured. The energy metabolism parameters were measured using indirect calorimetry. In serum, the metabolic and endocrine markers were analyzed. The adipogenic and thermoregulatory proteins expression in the white adipose tissue (WAT) were analyzed using an immunoblot assay. Results: Supplementation with both doses of LI85008F significantly increased resting energy expenditure (REE) in the obese rats. The LI85008F-250 rats showed significant up-regulation of uncoupling protein-1 (UCP-1) expression, as compared with the HFD rats. LI85008F significantly reduced body weight gain, fat mass, fat cell size, liver weight, and hepatic triglycerides. Serum triglyceride, total cholesterol, glucose, leptin, and fat cell markers were significantly reduced in LI85008F-supplemented rats compared to the HFD rats. Conclusion: The present data suggest that LI85008F reduces body fat mass and controls body weight gain via increasing energy metabolism in combination with reduced lipogenesis in diet-fed obese rats.

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Section: Animal Care and Experimental Designmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 88%

Section: Study Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Combined extracts of Moringa oleifera, Murraya koeingii leaves, and Curcuma longa rhizome increases energy expenditure and controls obesity in high-fat diet-fed rats

et al. 2020

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Effect of watercress extract supplementation on lipid profile and oxidative stress markers in overweight people with physical disability: A randomized, double‐blind, and placebo‐controlled trial

Clemente

Miguel

Gribner

et al. 2021

Phytotherapy Research

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Studies have demonstrated that diet rich in cruciferous vegetables of the Brassicaceae family can reduce the risk of cardiovascular diseases and oxidative stress levels. Nasturtium officinale (Brassicaceae), commonly known as watercress is a perennial dicotyledonous plant usually found close to water. Although previous investigations have demonstrated the beneficial effects of watercress on hypercholesterolemia in animal studies, until now no such studies have been conducted with humans, up to this time. This study aimed to investigate whether overweight individuals were able to improve or maintain their serum lipid and oxidative stress markers when given standardized extract of Nasturtium officinale (SENO) as a supplement. This was a randomized, double‐blind, and placebo‐controlled trial conducted over 5 weeks. Thirty‐four overweight people with physical disabilities were selected randomly to participate in this study and then they were assigned randomly to two groups, one treated with 750 mg//kg/d of SENO and the other treated with 750 mg/kg/d of placebo. The results indicated that SENO caused a significant improvement in the levels of low‐density lipoprotein cholesterol, creatinine, and lipid peroxidation. However, SENO did not cause a significant statistical change in total serum cholesterol, triacylglycerol, and high‐density lipoprotein levels; catalase, superoxide dismutase, creatinine, alanine aminotransferase, aspartate aminotransferase, and urea parameters. The present data might provide supportive evidence that SENO did not cause any harm and positively affected low‐density lipoprotein cholesterol profile and creatinine as well as lipid peroxidation levels in the participants. Nevertheless, further studies are suggested to clarify the results presented in this clinical trial.

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Functional foods - dietary or herbal products on obesity: application of selected bioactive compounds to target lipid metabolism

Sandner

König

Wallner

et al. 2020

Current Opinion in Food Science

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Efficacy of a novel herbal formulation for weight loss demonstrated in a 16‐week randomized, double‐blind, placebo‐controlled clinical trial with healthy overweight adults

Abstract: The unique herbal extract blend LI85008F, combined with modest calorie restriction and physical activity, is well tolerated, safe, and effective for weight management in overweight men and women.

Cited by 16 publications

References 18 publications

Combined extracts of Moringa oleifera, Murraya koeingii leaves, and Curcuma longa rhizome increases energy expenditure and controls obesity in high-fat diet-fed rats

Combined extracts of Moringa oleifera, Murraya koeingii leaves, and Curcuma longa rhizome increases energy expenditure and controls obesity in high-fat diet-fed rats

Effect of watercress extract supplementation on lipid profile and oxidative stress markers in overweight people with physical disability: A randomized, double‐blind, and placebo‐controlled trial

Functional foods - dietary or herbal products on obesity: application of selected bioactive compounds to target lipid metabolism

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