Efficacy of a novel microneedle patch for rejuvenation of the nasolabial fold

Pruettijarai, Ungsuthorn; Meephansan, Jitlada; Prapapan, Ornicha; Pureesrisak, Purit; Sirithanabadeekul, Punyaphat; Tantisantisom, Kittipong; Thongma, Sattra; Rayanasukha, Yossawat; Adulyaritthikul, Punyanuch; Khanchaitit, Paisan

doi:10.1111/srt.13199

Cited by 6 publications

(4 citation statements)

References 17 publications

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“… 6 Nasolabial folds look like wrinkles, because both are shaped by folding of the dermis. Several aesthetic techniques are used for nasolabial rejuvenation like microneedle, 7 , 8 radiofrequency, 9 and filler injection 10 , 11 , 12 , 13 but each method has its own risks. Ablative laser resurfacing by erbium: YAG (Er:YAG) laser and carbon dioxide laser is an effective method for rejuvenation of the skin but has probable side effects like, infection, prolonged erythema, and scarring.…”

Section: Introductionmentioning

confidence: 99%

Efficacy evaluation of endolift laser for treatment of nasolabial folds and marionette lines

Nilforoushzadeh,

Heidari‐Kharaji,

Fakhim

et al. 2023

Skin Research and Technology

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BackgroundThe nasolabial folds are the most marked sign of aging. Endolift laser was used for the treatment of nasolabial folds and marionette lines (one of the facial danger zones).MethodsTen female subjects were engaged in this study. Patients underwent Endolift laser for nasolabial folds and marionette lines treatment. The efficacy of the Endolift technique on the nasolabial folds and marionette lines was evaluated by biometric assessment with Cutometer, Visioface, and the Skin Ultrasound Imaging system. Also, patient's satisfaction and blinded dermatologists’ assessment were assessed.ResultsThe Visoface results displayed that the Endolift laser treatment significantly declined the depth and area of the nasolabial wrinkles. The skin ultrasonography results reported that the epidermis and dermis density and thickness were significantly increased. Also, the cutometer outcomes showed that the Endolift laser treatment can increase skin elasticity. The results showed that a large number of patients were very satisfied with the technique.ConclusionIn conclusion, Endolift laser has an effective technique for decreasing the nasolabial folds, marionette lines, and improve the appearance of the face without any sever side effect. This technique does not need general anesthesia and recovery time.

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Section: Introductionmentioning

confidence: 99%

Efficacy evaluation of endolift laser for treatment of nasolabial folds and marionette lines

Nilforoushzadeh,

Heidari‐Kharaji,

Fakhim

et al. 2023

Skin Research and Technology

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“…In a recent study in Thailand, 23 female Thai participants were treated with MNP and 1.8% hyaluronic acid (HA) to the right and left nasolabial folds. Patients treated with the MNP alone experienced significant improvements in their scores [18], with no differences reported in the improvement in wrinkles between the two groups. Similarly, treatment with 0.23 mm non-absorbable magnesium MNP under the eyes showed improvement in the grade of skin wrinkles and the index of dermal thickness after 12 weeks [15].…”

Section: Discussionmentioning

confidence: 87%

“…Moreover, the same type of MNP has also been developed for combined use with drug delivery and LED light therapy. In previous studies, it was found to be effective and free of adverse effects [18,24].…”

Section: Discussionmentioning

confidence: 98%

The Comparative Efficacy and Safety of 250 μm versus 350 μm Long Microneedle Patch on Under-Eye Skin

Arepagorn,

Meephansan,

Sirithanabadeekul

et al. 2024

Cosmetics

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Background: Microneedle patch (MNP) technology is now applied for many purposes, including transdermal drug delivery and percutaneous collagen induction in the cosmetic and dermatology fields. Previous research showed that a MNP effectively improved skin appearance, while treatments using larger or deeper microneedles were not easily tolerated by human subjects. Few studies have compared MNP designs in humans. Study Objective: To compare novel MNP designs with high length and low density versus low length and high density for rejuvenating skin wrinkles under the eyes. Methods: This non-randomized split-face clinical trial was conducted as a double-blind study with 36 Thai female participants. Each participant was treated with two different MNP designs, one on each side of the face. The microneedle lengths were 250 μm with a density of 945 needles/cm2 on the left side of the face under the eye and 350 μm with a density of 482 needles/cm2 on the right side of the face under the eye. The treatments were applied for 12 weeks, with the assessment outcomes evaluated at the baseline and 2, 4, 6, 8, 10, and 12 weeks. Results: The application of these two novel MNP designs successfully rejuvenated under-eye wrinkles with low pain level scores. Increasing the length of the needle or having a 350 μm long MN can better reduce under-eye wrinkles without statistical significance. During the study period, there was an improvement in skin surface roughness in both groups accompanied by a consistent reduction in under-eye skin wrinkles, without statistically significant differences observed between the groups when using the Antera 3D system. However, the 350 μm long MN also slightly increased the pain compared to the shorter needles (250 μm long MN) with a higher density of needles. There were no side effects associated with the two designs. Conclusions: The two novel MNPs gave favorable results as a safe non-invasive treatment for the rejuvenation of skin wrinkles under the eyes. Increasing the number of needles and increasing the length of the needles were both effective in safely reducing under-eye wrinkles without any adverse effects. Additionally, participants could self-apply them at home and were highly satisfied. However, increasing the length of the needles may result in slightly more pain compared to increasing the number of needles.

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“…Henry et al were the first to apply microneedles in the mainstream drug delivery field, sparking a boom in the industrialization of microneedles [ 139 ]. The length, height, and shape of microneedles can be individually tailored according to therapeutic requirements [ 140 , 141 ], and they can be categorized based on their morphology as solid, hollow, coated, dissolvable, and hydrogel microneedles. Microneedles based on BP, which exhibit photothermal conversion properties, have garnered significant attention in the field of skin tissue repair [ 142 ].…”

Section: Bp-based Composite Biomaterials For Tissue Repairmentioning

confidence: 99%

Advances in the Application of Black Phosphorus-Based Composite Biomedical Materials in the Field of Tissue Engineering

Qi,

Zhang,

Wang

et al. 2024

Pharmaceuticals

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Black Phosphorus (BP) is a new semiconductor material with excellent biocompatibility, degradability, and optical and electrophysical properties. A growing number of studies show that BP has high potential applications in the biomedical field. This article aims to systematically review the research progress of BP composite medical materials in the field of tissue engineering, mining BP in bone regeneration, skin repair, nerve repair, inflammation, treatment methods, and the application mechanism. Furthermore, the paper discusses the shortcomings and future recommendations related to the development of BP. These shortcomings include stability, photothermal conversion capacity, preparation process, and other related issues. However, despite these challenges, the utilization of BP-based medical materials holds immense promise in revolutionizing the field of tissue repair.

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Efficacy of a novel microneedle patch for rejuvenation of the nasolabial fold

Cited by 6 publications

References 17 publications

Efficacy evaluation of endolift laser for treatment of nasolabial folds and marionette lines

Efficacy evaluation of endolift laser for treatment of nasolabial folds and marionette lines

The Comparative Efficacy and Safety of 250 μm versus 350 μm Long Microneedle Patch on Under-Eye Skin

Advances in the Application of Black Phosphorus-Based Composite Biomedical Materials in the Field of Tissue Engineering

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