Efficacy of a proprietary combination of Tamarindus indica seeds and Curcuma longa rhizome extracts in osteoarthritis: a clinical investigation

Abstract

Background NXT15906F6 (TamaFlex™) is a proprietary blend containing standardized Tamarindus indica seeds and Curcuma longa rhizome extracts. Earlier, NXT15906F6 supplementation demonstrated reduced knee joint pain and improved musculoskeletal functions in healthy and knee osteoarthritis (KOA) subjects. Objective The present randomized, double-blind, placebo-controlled study was focused on validating the clinical efficacy of NXT15906F6 in a larger number of subjects with KOA. Methods Male and female subjects (age: 40–70 years; body mass index [BMI]: 20–29 kg/m 2 ] were randomized into three groups receiving placebo ( n = 50), NXT15906F6 ( n = 50) or a blend of C. longa and Boswellia serrata extracts (CLBS) ( n = 50). Subjects consumed 250 mg NXT15906F6, 1,000 mg CLBS or a matched placebo daily after breakfast over a period of 30 consecutive days. The primary efficacy outcome was the improvement in total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, and the secondary efficacy measures included various tests on joint pain and musculoskeletal functions and evaluations ofserum high-sensitivity C-reactive protein (hs-CRP) and a cartilage degradation marker, C-terminal telopeptide of type II collagen in urine (uCTX-II). Results NXT15906F6 significantly ( P < 0.001) reduced the WOMAC scores and improved musculoskeletal function scores in the participants as compared with baseline and placebo. NXT15906F6 participants reduced knee pain and improved musculoskeletal functions as early as day 5 of supplementation. In contrast, CLBS supplementation failed to show early efficacies in pain and functional scores, except for 30s-CST and primary knee flexion. The NXT1506F6-supplemented participants significantly reduced serum hs-CRP and uCTX-II levels from baseline and as compared with the placebo. Both supplementations did not alter the subjects’ clinical chemistry, hematology, and vital parameters. Conclusion The anti-inflammatory botanical composition NXT15906F6 supplementation mitigated joint pain and improved musculoskeletal functions and joint motility in KOA subjects. This botanical composition was also well-tolerated by the volunteers.

Calebin A modulates inflammatory and autophagy signals for the prevention and treatment of osteoarthritis

“…The bioavailability of curcumin could serve as an indication here, which, for many years, was considered to be low, but can now be significantly increased through special purification and new formulations that lead to improved intestinal absorption ( 45 ). Overall, the credibility of our new results was strengthened not only by repeated experiments but also by other phytotherapeutics with noticeable anti-OA properties, for example, extracted from Luzula sylvatica ( 46 ), Olea europaea ( 40 ), Uncaria rhynchophylla ( 44 ), Boswellia serrata , Curcuma longa , or Tamarindus indica ( 47 ). Therefore, an establishment of plant-based supplements for OA prevention or co-therapy could represent an approach worth pursuing.…”