Efficacy of a Proprietary Fenugreek Seed Extract (<i>Trigonella foenum-graecum</i>, Furocyst®) in Women with Polycystic Ovary Syndrome (PCOS): a Randomized, Double-Blind, Placebo-Controlled Study

Singh, Amarjeet; Gainder, Shalini; Banerjee, Pradipta; Goel, Apurva; Kumar, Pawan; Mondal, Banashree; Banik, Samudra Prosad; Bagchi, Debasis

doi:10.1080/27697061.2022.2126410

Cited by 4 publications

(1 citation statement)

References 42 publications

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“…Fenugreek is another option for plan-based treatment for women with PCOS. Two recent studies showed that a Fenugreek seed extract has a beneficial effect on serum lipoproteins, causing a small but significant increase of HDL-C after 12 weeks of therapy in one study ( 35 ) and a decrease in TC, LDL-C, and TG when compared to placebo in another trial ( 36 ). The benefits of propolis administration in PCOS have been examined by a recent randomized, triple-blinded, placebo-controlled trial.…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

Lipoprotein alterations in endocrine disorders - a review of the recent developments in the field

Olejarz,

Szczepanek-Parulska,

Ruchala

2024

Front. Endocrinol.

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Dyslipidemia is one of the most common disorders worldwide, which, if left untreated, results in a multitude of complications. Thus proper diagnostics, which includes identifying of secondary causes of dyslipidemia is crucial. Endocrine disorders are an important cause of secondary dyslipidemia. This paper aims to review the publications on lipoprotein alterations in endocrine disorders from the past two years and provide an overview of the recent discoveries in this dynamically developing and large field. Significant changes in lipoprotein serum concentrations are present in most endocrinological diseases and can be modified with proper treatment. Some lipoproteins have also been proposed as markers in some endocrine diseases, e.g., thyroid carcinoma. From the scope of endocrine disorders, the largest number of studies explored the lipoprotein changes in polycystic ovary syndrome and in women during the menopausal and peri-menopausal period. Even though the association of thyroid disorders with dyslipidemia is already well studied, new research has delivered some exciting findings about lipoprotein alterations in euthyroid patients with either positive antithyroid peroxidase antibodies or reduced sensitivity to thyroid hormones. The problem of the adverse metabolic profile, including dyslipidemia in hypoprolactinemia has been recognized. Moreover, this review describes other significant discoveries encompassing lipoprotein alterations in disorders of the adrenals, thyroid, parathyroid glands, pituitary, and gonads. The up-to-date knowledge of the influence of endocrine disorders and hormonal changes on serum lipoproteins is prudent as it can significantly impact therapeutic decisions.

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Section: Polycystic Ovary Syndromementioning

confidence: 99%

Lipoprotein alterations in endocrine disorders - a review of the recent developments in the field

Olejarz,

Szczepanek-Parulska,

Ruchala

2024

Front. Endocrinol.

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Fenfuro®-mediated arrest in the formation of protein-methyl glyoxal adducts: a new dimension in the anti-hyperglycemic potential of a novel fenugreek seed extract

Prosad Banik,

Kumar,

Bagchi

et al. 2024

Toxicology Mechanisms and Methods

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Current perspectives on fenugreek bioactive compounds and their potential impact on human health: A review of recent insights into functional foods and other high value applications

Alu'datt,

Rababah,

Al‐ali

et al. 2024

Journal of Food Science

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Despite long‐standing uses in several food and medicine traditions, the full potential of the leguminous crop fenugreek (Trigonella foenum‐graecum L.) remains to be realized in the modern diet. Not only its seeds, which are highly prized for their culinary and medicinal properties, but also its leaves and stems abound in phytochemicals with high nutritional and health promoting attributes. Fenugreek dual food‐medicine applications and reported metabolic activities include hypoglycemic, antihyperlipidemic, antioxidative, anti‐inflammatory, antiatherogenic, antihypertensive, anticarcinogenic, immunomodulatory, and antinociceptive effects, with potential organ‐protective effects at the cardiovascular, digestive, hepatic, endocrine, and central nervous system levels. Effectiveness in alleviating certain inflammatory skin conditions and dysfunctions of the reproductive system was also suggested. As a food ingredient, fenugreek can enhance the sensory, nutritional, and nutraceutical qualities of a wide variety of foods. Its high nutritive density can assist with the design of dietary items that meet the demand for novelty, variety, and healthier foods. Its seeds provide essential protective nutrients and other bioactive compounds, notably galactomannans, flavonoids, coumarins, saponins, alkaloids, and essential oils, whose health benefits, alone or in conjunction with other bioactives, are only beginning to be tapped into in the food industries. This review summarizes the current state of evidence on fenugreek potential for functional food development, focusing on the nutrients and non‐nutrient bioactive components of interest from a dietary perspective, and their applications for enhancing the functional and nutraceutical value of foods and beverages. New developments, safety, clinical evidence, presumed mechanisms of action, and future perspectives are discussed.Highlights Fenugreek seeds and leaves have long‐standing uses in the food‐medicine continuum. Fenugreek phytochemicals exert broad‐spectrum biological and pharmacological activities. They show high preventive and nutraceutical potential against common chronic diseases. Current evidence supports multiple mechanisms of action mediated by distinct bioactives. Opportunities for fenugreek‐based functional foods and nutraceuticals are expanding.

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Efficacy of a Proprietary Fenugreek Seed Extract (Trigonella foenum-graecum, Furocyst®) in Women with Polycystic Ovary Syndrome (PCOS): a Randomized, Double-Blind, Placebo-Controlled Study

Cited by 4 publications

References 42 publications

Lipoprotein alterations in endocrine disorders - a review of the recent developments in the field

Lipoprotein alterations in endocrine disorders - a review of the recent developments in the field

Fenfuro®-mediated arrest in the formation of protein-methyl glyoxal adducts: a new dimension in the anti-hyperglycemic potential of a novel fenugreek seed extract

Current perspectives on fenugreek bioactive compounds and their potential impact on human health: A review of recent insights into functional foods and other high value applications

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