Health care providers serving vulnerable patients in Los Angeles have developed programs intended to increase diabetes control through more intensive patient education and engagement. We examined two programs, the first using a short-term intensive intervention by a care team including nurses and a specialist, and the second integrating case management and clinical pharmacy programs into primary care in a community clinic. We show evidence that both models improved short-term disease control, as measured by reductions in HbA1c (blood glucose) and low-density lipoprotein (sometimes referred to as ”bad” cholesterol). However, integrating case management and clinical pharmacy programs into a primary care setting was less labor intensive and potentially less expensive than the care team intervention. The challenge is to understand the essential aspects of these interventions; refining their design so that they are cost-effective and fiscally feasible; and identifying long-term health and cost effects.