Efficacy of a Standardized Oral Vitamin D Dosing Regimen in Nursing Home Residents

Toren-Wielema, Marlous; Veenhuizen, Ruth B.; Kappelle, J.W.; Veeger, Nic J. G. M.; Roon, Eric van

doi:10.1007/s40266-018-0601-z

Cited by 4 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The final number of articles included in the review was 58. Of the 58 studies, we identified 26 observation studies (Table 2), 18 vitamin D-intervention studies to improve vitamin D status (Table 3), [47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64] and 14 studies that intervened with vitamin D alone or in combination with other nutrients or therapies and assessed health outcomes (Table 4). [65][66][67][68][69][70][71][72][73][74][75][76][77][78] For cohort, case-control, and cross-sectional studies, 2 of 32 studies scored 13 of 13 stars and 10 studies scored !10 stars.…”

Section: Resultsmentioning

confidence: 99%

“…Duration of supplementation ranged from 4 weeks to 1 year, and the dose regimen ranged from 0 to 4000 IU/d, 5600 to 100 000 IU/wk, or 400 000 IU every 2 weeks. Method of administration included loading doses (100 000 IU 3-4 times every 2 wk) 59 followed by a maintenance dose (monthly dose of 25 000 IU or 50 000 IU, or 100 000 IU every 13 wk), 57,61 a single "megadose" (600 000 IU), 53 a daily dose (0 to 2000 IU), 47,[49][50][51] and a daily dose (800 IU) vs weekly supplementation (8000-50 000 IU). 55,58,60 Vitamin D supplementation regimens to normalize vitamin D status in nursing home residents with severe deficiency, deficiency, or insufficiency were investigated in 4 studies.…”

Section: Supplementation Of Vitamin D and Its Effect On Raising Vitam...mentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D deficiency in nursing home residents: a systematic review

et al. 2022

View full text Add to dashboard Cite

Context Vitamin D deficiency is a global public health issue, particularly in nursing home residents. Objective This review critically summarizes the prevalence of vitamin D deficiency in nursing home residents worldwide. In addition, it outlines the effect of vitamin D intervention, alone or in combination with other nutrients or therapies, on improving vitamin D status and associated health outcomes in nursing home residents. Data Sources, Extraction, and Analysis Searches were conducted of electronic databases for articles published from 2010 to May 2021. After screening of the 366 papers initially identified, 58 articles were included. Conclusions A paucity of observational studies in nursing homes suggests a high prevalence of vitamin D deficiency ranging from 8% [25(OH)D <25 nmol/L], up to 94% [25(OH)D <50 nmol/L] in some cohorts where supplement use was low. Reported factors associated with deficiency and suboptimal vitamin D status include lack of sunlight exposure, poor dietary intake of vitamin D, limited vitamin D food fortification, frailty, poor renal function, and low use of vitamin D supplements. Residents who are severely deficient, deficient, or insufficient in vitamin D require remedial vitamin D supplementation prior to maintenance supplementation at doses >800 IU/day. High-dose vitamin D supplementation may reduce respiratory illness; however, supportive data are limited. Oral nutritional supplements, in combination with exercise, may benefit physical function and performance, whereas supplementation with vitamin D– and calcium-fortified foods has been associated with improved quality of life and reduced bone resorption. Globally, vitamin D deficiency is highly prevalent in nursing home residents. There is an urgent need for standardized dietary and supplementation guidelines to prevent deficiency in this vulnerable group.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Supplementation Of Vitamin D and Its Effect On Raising Vitam...mentioning

confidence: 99%

Vitamin D deficiency in nursing home residents: a systematic review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…An alternative approach using the loading dose of 200,000 IU and maintenance dose (100,000 IU) administered every 13 weeks also failed to reach and maintain the vitamin D concentration of 75-220 nmol/L in nursing home residents ( 30 ). Another study suggested that an individualized loading dose of vitamin D be given to those with severe 25(OH)D deficiency ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

The effect of standard-dose wintertime vitamin D supplementation on influenza infection in immunized nursing home elderly residents

Hauptman¹,

Lukić-Grlić²,

Vraneš³

et al. 2021

Croat Med J

View full text Add to dashboard Cite

“…However, instead of attributing these discrepancies to genetic susceptibility or unavoidable effects of aging there is an evolving recognition that asymmetries of socioeconomic status , chronic stress, the availability of routine and acute medical care, and exposure to toxic environmental factors may be primarily responsible for the increased morbidity being suffered by these groups [3,8]. These same groups are also known to be disproportionately 25-hydroxyvitamin D (25VD) insu cient (serum levels of 20-30 ng/dL) or de cient (serum levels<20 ng/dL) [9,10,11]. While the etiology of the necrotizing pulmonary process is no doubt multifactorial, vitamin D de ciency has been targeted as is a candidate factor for abetting some of the dysfunctional hyperin ammation [12,13] occurring in these patients.…”

mentioning

confidence: 99%

Vitamin D Deficiency is Associated with Increased COVID-19 Severity: Prospective Screening of At-Risk Groups is Medically Indicated

Pepkowitz

Hobel

Mirocha

et al. 2020

Preprint

View full text Add to dashboard Cite

Non-classical actions of Vitamin D are involved in regulation of the immune system including a role in mitigation of excessive inflammation. We hypothesized that vitamin D deficiency existing prior to SARS-CoV-2 infection could contribute to patients developing severe pulmonary compromise as a result of dysfunctional hyperinflammation. Serum vitamin D concentrations of patients experiencing such severe COVID-19 manifestations that they required ICU care at any point of their hospitalization were compared to serum vitamin D concentrations of patients achieving discharge without the need for any ICU care. Having serum vitamin D < 20 ng/mL was significantly associated with increased COVID-19 severity, p=0.001. It is conjectured that population groups know to have low serum vitamin D should be prospectively screened for deficiency and if found emergently treated. Such action could both decrease the maximum severity suffered by infected individuals and lessen the strain on medical resources by decreasing the percentage of COVID-19 hospital admissions requiring ICU care.

show abstract

Efficacy of a Standardized Oral Vitamin D Dosing Regimen in Nursing Home Residents

Abstract: Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Cited by 4 publications

References 35 publications

Vitamin D deficiency in nursing home residents: a systematic review

Vitamin D deficiency in nursing home residents: a systematic review

The effect of standard-dose wintertime vitamin D supplementation on influenza infection in immunized nursing home elderly residents

Vitamin D Deficiency is Associated with Increased COVID-19 Severity: Prospective Screening of At-Risk Groups is Medically Indicated

Contact Info

Product

Resources

About