Efficacy of a topical combination of eprinomectin, praziquantel, fipronil and (S)-methoprene against developing and adult Troglostrongylus brevior lungworms (Nematoda, Crenosomatidae) in cats

Knaus, Martin; Visser, Martin; Mayr, Sandra; Rehbein, Steffen

doi:10.1016/j.vpoa.2020.100032

Cited by 8 publications

(9 citation statements)

References 39 publications

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“…(NexGard ® Spectra) and moxidectin spot-on (2.5%) (Advocate ® ), is effective in preventing thelaziosis in dogs [23,24]. Considering that the topical combination containing fipronil, (S)methoprene, eprinomectin and praziquantel is highly efficacious against developing stages of lungworms and heartworms [25][26][27], its efficacy in preventing the establishment of adult Thelazia in cats is worth of further studies.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of fipronil/(S)-methoprene/eprinomectin/praziquantel (Broadline®) against Thelazia callipaeda in naturally infected cats

et al. 2021

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Background The present clinical field trial was conducted to assess the efficacy of a broad-spectrum parasiticide spot-on formulation containing eprinomectin (Broadline®) against Thelazia callipaeda eyeworm in naturally infected cats. Methods Fifteen privately owned cats harboring at least one live adult T. callipaeda were included in the study. Cats were randomly allocated to an untreated control group of seven cats or to a Broadline®-treated group of eight cats. Cats were treated on Day 0; ocular examinations were performed at inclusion and on Days 7 and 14; eyeworms were recovered and counted on Day 14. The primary efficacy assessment was based on group comparison of number of T. callipaeda on Day 14. Results Seven days after treatment, six of eight treated cats were negative for eyeworm infection per visual examination, and on Day 14 no eyeworms were found in the treated cats while the seven untreated cats were still infected (geometric mean: 1.97). All cats had inflammatory ocular signs at inclusion; on Day 14, five of eight treated cats had recovered while all untreated control cats were still symptomatic. All collected parasites were confirmed to be T. callipaeda by morphology and molecular characterization. Conclusions A single treatment with Broadline® provided 100% efficacy against feline thelaziosis and improved related ocular inflammation signs. Graphical abstract

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Section: Discussionmentioning

confidence: 99%

Efficacy of fipronil/(S)-methoprene/eprinomectin/praziquantel (Broadline®) against Thelazia callipaeda in naturally infected cats

et al. 2021

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“…The equivalent levels of efficacy demonstrated against adult T. cati and D. caninum, which were considered the least sensitive nematode and cestode species for eprinomectin and praziquantel, respectively, may reasonably allow to conclude that the administration of NexGard ® Combo to cats will provide the same range of activity as does the administration of Broadline TM with respect to nematode and cestode infections. Thus, the spectrum of activity of NexGard ® Combo in cats may comprise migrating and intestinal larval T. cati , adult Toxascaris leonina , adult and fourth-stage A. braziliense, A. ceylanicum and A. tubaeforme hookworms, adult and larval Aelurostrongylus abstrusus and Troglostrongylus brevior lungworms, vesical and pulmonary Capillaria ( C. plica, C. aerophila ) and Diplopylidium spp., and J. pasqualei and T. taeniaeformis cestodes [ 19 – 26 , 31 – 33 ] in addition to adult T. cati , D. caninum and E. multilocularis .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel in cats againstToxocara catiandDipylidium caninum

et al. 2021

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NexGard® Combo, a novel topical antiparasitic product for cats, combines the insecticide/acaricide esafoxolaner with the nematocide eprinomectin and cestodicide praziquantel. The efficacy of this combination product was evaluated against two common endoparasites of global occurrence in cats, the nematode Toxocara cati and the cestode Dipylidium caninum, in five controlled studies using naturally or experimentally infected cats with parasites of North American, South African or European origin. Cats evaluated in these studies harbored patent infection of the target parasite confirmed through a pre-treatment fecal examination. In each study, cats were allocated randomly to two groups of equal size (8 or 10 cats per group per study), one group treated with a placebo (mineral oil) and the other with NexGard® Combo. Both treatments were administered once as a spot-on at 0.12 mL per kg body weight to deliver the minimum label dosage (1.44 mg/kg esafoxolaner, 0.48 mg/kg eprinomectin, and 10.0 mg/kg praziquantel) to the NexGard® Combo-treated cats. To determine efficacy, geometric mean parasite counts seven to 12 days after treatment of placebo-treated (control) cats and NexGard® Combo-treated cats were compared. The efficacy of NexGard® Combo was 98.8% and 100% against adult T. cati in two studies; and 98.0%, 98.3% and 93.2% against D. caninum in three studies. No adverse events related to treatment were observed throughout the studies. These studies demonstrate high efficacy against these major feline endoparasites and excellent acceptability of the novel topical antiparasitic combination of esafoxolaner, eprinomectin and praziquantel.

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“…In this latter case, a false negative result cannot be ruled out and the lack of L1 in the faeces does not exclude a transplacental infection, that might take place when the pregnant cat ingests L3 and passes L4 to the foetuses, without patency in the queen. A transplacental transmission cannot be ultimately excluded either in the 18-days-old kittens [ 72 ], as the prepatent period for T. brevior reported in the literature is 24-28 days [ 54 , 73 ] and recent experimental data indicate that L1 are shed the at earliest 20 days after infection, when cats get infected with L3 (Raue K. and Strube C., Institute for Parasitology, Center for Infectious Diseases, University of Veterinary Medicine Hannover, personal communication). Regardless if the parasite is transmitted in utero and/or lactogenically, it is unknown whether the vertical transmission takes place after recent infection in a late phase of pregnancy (as for the roundworm Toxocara cati [ 74 ]), or in already infected queens that become pregnant.…”

Section: Novel Biological Acquisitions: Hypotheses and Factsmentioning

confidence: 99%

Felid Cardiopulmonary Nematodes: Dilemmas Solved and New Questions Posed

et al. 2021

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In the past decade cardiopulmonary nematodes affecting felids have become a core research topic in small animal parasitology. In the late 2000s, an increase in studies was followed by unexpected findings in the early 2010s, which have stimulated research teams to start investigating these intriguing parasites. Prolific scientific debate and exchanges have then fostered field and laboratory studies and epizootiological surveys. New data have improved basic and applied knowledge, solved dilemmas and posed new questions. This article discusses the past and present background to felid cardiopulmonary nematodes after the last few years of intense scientific research. New data which have demonstrated the key role of Aelurostrongylus abstrusus and Troglostrongylus brevior in causing respiratory infections in domestic cats, and on the nil to negligible current importance of other species, i.e., Troglostrongylus subcrenatus, Oslerus rostratus and Angiostrongylus chabaudi, are presented. Biological information and hypothesized alternative routes of infection are analysed and discussed. Novel identification and taxonomical data and issues are reported and commented upon. On the whole, recent biological, ecological and epizootiological information on felid metastrongyloids is critically analysed, with the aim to answer outstanding questions, stimulate future studies, and underline new research perspectives.

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Efficacy of a topical combination of eprinomectin, praziquantel, fipronil and (S)-methoprene against developing and adult Troglostrongylus brevior lungworms (Nematoda, Crenosomatidae) in cats

Abstract: Highlights Broadline® is 100 % effective against Troglostrongylus brevior in cats. A treatment has beneficial effects on pathology and health status of the cats.

Cited by 8 publications

References 39 publications

Efficacy of fipronil/(S)-methoprene/eprinomectin/praziquantel (Broadline®) against Thelazia callipaeda in naturally infected cats

Efficacy of fipronil/(S)-methoprene/eprinomectin/praziquantel (Broadline®) against Thelazia callipaeda in naturally infected cats

Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel in cats againstToxocara catiandDipylidium caninum

Felid Cardiopulmonary Nematodes: Dilemmas Solved and New Questions Posed

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