Efficacy of adapalene/benzoyl peroxide combination in moderate inflammatory acne and its impact on patient adherence

Abstract

Adapalene-BPO is effective and safe in the treatment of moderate inflammatory acne. The fixed-dose combination and easy application simplifies the therapeutic regimen, leading to good treatment adherence in the majority of patients.

Azelaic acid 20 % cream: effects on quality of life and disease severity in adult female acne patients

“…Treatment with azelaic acid 20 % cream for a period of twelve weeks resulted in statistically significant improvement of acne severity and quality of life. As already reported for younger patient populations , this shows that effective treatment is able to alleviate the physical and psychological stress associated with adult acne. Both the DLQI scores and IGA grades already showed marked improvement at 4–8 weeks post treatment initiation, which became even more pronounced between follow‐up visits 1 and 2.…”

Current treatments of acne: Medications, lights, lasers, and a novel 650‐μs 1064‐nm Nd: YAG laser

“…In response to these recommendations, the use of fixed‐dose adapalene in combination with BPO has been explored recently in 2,780 young adults and adolescents with moderate inflammatory acne, 73 Brazilian patients with papular‐pustular acne, more than 2,300 patients with inflammatory and noninflammatory lesions by meta‐analysis, and 503 patients with moderate and severe acne in 31 centers . Advantages of this fixed‐dose combination are that it is efficacious, well tolerated, useful in all forms of acne, not associated with antibiotic resistance, improves quality of life, reduces factors associated with adherence, and can be used for long‐term treatment of chronic acne …”

Verantwortlicher Umgang mit Antibiotika: Notwendigkeit der Antibiotikareduktion in der Aknetherapie

“…Während man bei der Acne comedonica die alleinige Gabe von Retinoiden als Primärtherapie empfiehlt , ist die Standardtherapie bei Acne vulgaris topische Retinoide und Benzylperoxid (BPO) . Bei Akne mit mildem bis moderatem Verlauf zeigte die standard‐dosierte Kombination von Adapalen‐BPO überzeugende Resultate bei Kurzzeit‐ sowie Langzeitbehandlungen . Als Resultat komplementärer Mechanismen zielt die topische retinoidbasierte Kombinationstherapie, erstmals 2003 durch die Global Alliance to Improve Outcomes in Acne empfohlen , auf drei der vier wichtigsten pathogenen Faktoren von Akne ab: die gestörte Keratinisierung und verminderte Desquamation im Infundibulum, die Hyperproliferation von P. acnes sowie primäre und sekundäre Entzündungsvorgänge .…”