Efficacy of amiodarone and voriconazole combination therapy in cutaneous leishmaniasis in the mice experimentally infected with Leishmania major

Bahrami, Somayeh; Oryan, Ahmad; Bemani, Effat

doi:10.1016/j.jiac.2021.02.011

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…Recent works have shown that combination therapy for leishmaniasis has progressively been recommended to increase treatment tolerance and efficacy, reduce cost and treatment duration, and limit the growth of drug resistance [72][73][74][75]. For the treatment of leishmaniasis, WHO has recommended combination therapy based on many studies showing the efficacy of this therapeutic tool; the combinations include novel synthesized drugs, nanoparticles developed for drug delivery, repositioned drugs, old medicines, and immunomodulatory agents [76][77][78][79]. Indeed, several studies have reported the superior efficacies of combination therapies against leishmaniasis.…”

Section: Therapeutic Combination: What Do We Know?mentioning

confidence: 99%

“…In vitro studies against L. amazonensis suggest that combinations between compounds that act in different biosynthetic pathways of the parasite, such as sterol biosynthesis, are promising [32]. Interestingly, a recent study showed that sterol biosynthesis inhibitors and alkylphosphocholine analogs, combined with medicines available to treat other diseases, are efficient against trypanosomatids [32,36,78,84]. Besides, another study showed the in vivo efficacy of the combination therapy between miltefosine, an alkylphosphocholine, and amphotericin B or paromomycin [85], a therapeutic alternative to treat antimony-resistant VL cases in India.…”

Section: Therapeutic Combination: What Do We Know?mentioning

confidence: 99%

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Use of Cell Biology to Identify Cellular Targets in Drug Development Process against Leishmania Sp.

Miranda¹,

Godinho²,

Macedo-Silva³

et al. 2022

Leishmaniasis - General Aspects of a Stigmatized Disease

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Leishmaniasis is one of the most important neglected tropical diseases. The chemotherapy for its treatment uses very toxic compounds with a low efficacy rate. Thus, there is an urgent need to develop new chemotherapeutic agents to help countries control this devasting disease. In drug development, different approaches can be used to identify potential cellular targets that allow us to understand better the cell biology of eukaryotic cells. Several groups are dedicated to studying new molecules, searching for promising candidates against Leishmania. Different techniques have been used to characterize the cell biology, biochemistry, and molecular biology alterations induced by the treatments, trying to understand the mechanisms of action. The main goal of this chapter is to describe an overview of the literature exploring the several studies published about the chemotherapy of anti-Leishmania concerning the mechanisms of action of different classes of molecules or therapeutic alternatives.

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Section: Therapeutic Combination: What Do We Know?mentioning

confidence: 99%

Section: Therapeutic Combination: What Do We Know?mentioning

confidence: 99%

Use of Cell Biology to Identify Cellular Targets in Drug Development Process against Leishmania Sp.

Miranda¹,

Godinho²,

Macedo-Silva³

et al. 2022

Leishmaniasis - General Aspects of a Stigmatized Disease

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“…This compound has been tested against different protozoan parasites such as Trypanosoma cruzi [39][40][41][42], Acanthamoeba castellanii [43], Leishmania spp. [42,[44][45][46], and Plasmodium [47].…”

Section: Amiodaronementioning

confidence: 99%

New Uses for Old Drugs and Their Application in Helminthology

Río-Araiza¹,

Hernández-Bello²,

Morales‐Montor³

2022

Parasitic Helminths and Zoonoses - From Basic to Applied Research

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Parasitic infection research, performed on both humans and domestic animals, has been mostly focused on vaccines, diagnostic methods, epidemiology, and the evolutionary origins of parasites, thanks to the emergence of genomics and proteomics. However, the basic biology of the host-parasite interactions of several medical or veterinary important parasites has not been fully studied. Limited information has been obtained on the intricate neuroimmunoendocrine effects of host-parasite interplay in particular; therefore, the consequences of these interactions, and their possible therapeutic applications, are in need of thorough research. The current manuscript attempts to review the available literature regarding the host-parasite neuroimmunoendocrine network and to discuss how this basic research can be used to design new treatments using hormones, antihormones, and hormone analogs as a novel therapy against parasitic diseases. In addition, these studies may also contribute in identifying alternative treatments for parasitic diseases in the future. The complex immune-endocrine network may also help in explaining the frequently conflicting results observed in infections with regards to host sex and age and offer helpful insight into other research avenues besides parasite treatment and control strategies. Finally, several natural products isolated from plants, used in traditional medicine, offer an alternative approach for natural products in the preparation of inexpensive and effective antiparasitic drugs.

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Target-Based Rational Improvement Strategies and Pitfalls in Leishmania Drug Discovery

Gupta,

Goicoechea,

Vance

et al. 2023

Natural Product Based Drug Discovery Against Human Parasites

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Efficacy of amiodarone and voriconazole combination therapy in cutaneous leishmaniasis in the mice experimentally infected with Leishmania major

Cited by 5 publications

References 25 publications

Use of Cell Biology to Identify Cellular Targets in Drug Development Process against Leishmania Sp.

Use of Cell Biology to Identify Cellular Targets in Drug Development Process against Leishmania Sp.

New Uses for Old Drugs and Their Application in Helminthology

Target-Based Rational Improvement Strategies and Pitfalls in Leishmania Drug Discovery

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