Efficacy of an Inactivated and a Fowlpox-Vectored Vaccine in Muscovy Ducks Against an Asian H5n1 Highly Pathogenic Avian Influenza Challenge

Steensels, Mieke; Borm, Steven Van; Lambrecht, Bénédicte; Vriese, J. De; Gros, F-X. Le; Bublot, M.; Berg, Thierry van den

doi:10.1637/1933-5334(2007)2[e30:eoaiaa]2.0.co;2

Cited by 1 publication

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both vaccines protected the ducks against clinical signs and mortality and both vaccines were effective in reducing viral excretion through the oropharynx and cloaca. However, the classical inactivated H5N9-It vaccine proved to be significantly more effective than the recombinant vaccine, Trovac TM (42).…”

Section: Recombinant Vaccinesmentioning

confidence: 99%

“…Most published studies show that inactivated whole-virus vaccines are also effective in ducks (1,18,41,42,44,49,52,54,55) and geese (49) but species react differently (40). However, the current inactivated AI vaccines have a limited efficacy in Anseriformes and therefore require twice the antigenic load used for chickens and/or the addition of a strong stimulator for the immune response to be effective (41,42). Recently, it was shown that a double dose of a bivalent vaccine protected ducks against disease and mortality, while only a low antibody response was induced (4 to 8 log 2 ), and virus could be re-isolated from some (13%) of the vaccinated ducks (100% for non-vaccinated ducks) (24,42).…”

Section: Inactivated Vaccinesmentioning

confidence: 99%

“…However, the current inactivated AI vaccines have a limited efficacy in Anseriformes and therefore require twice the antigenic load used for chickens and/or the addition of a strong stimulator for the immune response to be effective (41,42). Recently, it was shown that a double dose of a bivalent vaccine protected ducks against disease and mortality, while only a low antibody response was induced (4 to 8 log 2 ), and virus could be re-isolated from some (13%) of the vaccinated ducks (100% for non-vaccinated ducks) (24,42). The failure of the challenge H5N1 virus to stimulate a secondary antibody response in ducks vaccinated with the closely related H5 of the monovalent vaccine is very strong evidence that there was minimal to no replication of the challenge virus in those vaccinated ducks (24).…”

Section: Inactivated Vaccinesmentioning

confidence: 99%

“…Field experience with vaccination against HPAI, especially in exotic bird species, is scarce (28). Research has mainly been performed on poultry and, most recently, ducks (24,42,44,52). Data on the vaccination of other species remain limited (32,34).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Vaccination of birds other than chickens and turkeys against avian influenza

Koch¹,

Steensels²,

Berg³

2009

Rev. Sci. Tech. OIE

Self Cite

View full text Add to dashboard Cite

Most avian influenza (AI) vaccination and field studies have focused on chickens and turkeys because of their high death rates and the large amounts of highly pathogenic avian influenza (HPAI) virus that they excrete into the environment when infected. Data on vaccination of other species against HPAI remain limited. An increasing number of studies have been conducted to test the efficacy of inactivated vaccines in ducks and geese since it became clear that these species are a source of HPAI H5N1. One problem is the varying susceptibility of waterfowl to H5N1 in general, and to different H5N1 clades in particular. This makes the extrapolation of protection results obtained for a particular waterfowl species against a particular viral strain very difficult. At present, the vaccine industry only produces and licenses products for chickens and turkeys. Since the market for other birds is small, it does not invest heavily in testing products in other species. Most information on vaccination in other birds comes from zoo vaccination, and consists solely of serological data. Whenever experimental challenge was performed in birds other than chickens and turkeys, vaccination using inactivated vaccines always protected against disease and mortality, provided the vaccine was sufficiently matched antigenically with the challenge virus. Inactivated vaccines induce good antibody titres in most species when applied twice and when body weight is taken into account. Until the advent of more specific waterfowl vaccines that can be used in day-old chicks, inactivated vaccines can be applied to protect not only chickens and turkeys but also ducks and other valuable and/or endangered bird species.

show abstract

Section: Recombinant Vaccinesmentioning

confidence: 99%