Efficacy of anti‐inflammatory moisturizer vs hydrophilic cream in elderly patients with moderate to severe xerosis: A split site, triple‐blinded, randomized, controlled trial

Lueangarun, Suparuj; Soktepy, Bith; Tempark, Therdpong

doi:10.1111/jocd.13183

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…Xerosis, also known as dry skin, xeroderma, or xerosis cutis, is determined by structural and functional changes in keratinocytes due to an imbalance between hydrophilic and lypophilic content [ 79 ]. Generally, there is a decrease in water and lipid components in the stratum corneum, and consequently a decrease in stratum corneum hydration and an increase in TEWL [ 80 ]. The symptoms of this very common dermatological condition include pruritus and a feeling of tightness.…”

Section: Discussionmentioning

confidence: 99%

Stability Profile and Clinical Evaluation of an Innovative Hydrogel Containing Polymeric Micelles as Drug Delivery Systems with Oregano Essential Oil against Fibroepithelial Polyps

et al. 2023

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Skin tags, also known as fibroepithelial polyps (FPs) or acrochordons, are soft, pigmented excrescences, with a prevalence of 50–60% in the population, occurring especially in the fourth decade of life. To date, FPs have been efficiently eliminated using minimum invasive methods such as surgical removal, cauterization, laser irradiation, and cryosurgery. Over-the-counter treatments are also of interest for patients due to their non-invasive character, but their clinical efficiency has not been clearly demonstrated. This study was designed in order to evaluate the efficacy of a modern-pharmaceutical-formulation-type poloxamer-based binary hydrogel, having Origanum vulgare L. essential oil (OEO-PbH) as an active ingredient in the management of FPs. The formulation has been shown to possess good qualities in terms of stability and sterility. Non-invasive measurements revealed changes in some physiological skin parameters. An increase in transepidermal water loss (TEWL) and erythema index was noted, while skin surface water content (SWC) decreased during eight weeks of treatment. The macroscopic evaluation revealed that the FPs dried and shrunk after topical treatment with OEO-PbH. Clinically, patients presented a lowering of the number of lesions on the treated area of 20–30% after one month of treatment and around 50% after the second month. Histopathological examination suggests that topical treatment with OEO-PbH may induce histological changes in the epidermis, dermis, and fibrovascular cores of FPs, including a loss of thickness, reduced size and number of blood vessels, and low cellularity. These changes may contribute to the observed reduction in size of FPs after treatment with OEO-PbH.

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Section: Discussionmentioning

confidence: 99%

Stability Profile and Clinical Evaluation of an Innovative Hydrogel Containing Polymeric Micelles as Drug Delivery Systems with Oregano Essential Oil against Fibroepithelial Polyps

et al. 2023

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“…Comments : Many studies of moisturizers containing different moisturizing components involving elderly patients with asteatosis were conducted. Moisturizers containing heparinoids, 66–68 urea, 67,69 ceramide, 70 glycerol, 46 urea/ceramide NP/lactate, 71 diethylene glycol/dilinoleic copolymer, 72 glyceryl glucoside/natural moisturizing factors, 73 or vitis vinifera, vitamin C, vitamin E, telmesteine, hyaluronic acid, glycyrrhetinic acid, and shea butter 74 significantly reduced clinical findings of asteatosis and pruritus, improving the stratum corneum function (stratum corneum water content, TEWL, pH) in comparison with a control drug/base, untreated group, or state before administration. A systematic review of moisturizers for asteatosis in the elderly also concluded that moisturizers significantly reduced dry skin 75 .…”

Section: Cq1 Are Moisturizers Useful For Treating Age‐related Asteato...mentioning

confidence: 99%

English version of guidelines for the management of asteatosis 2021 in Japan

Saeki

Tsunemi

Arai

et al. 2021

The Journal of Dermatology

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This is the English version of guidelines for the management of asteatosis 2021 in Japan. Asteatosis is a synonym of xerosis found in a wide range of diseases that induce dry skin through impaired functions of either water retention of the stratum corneum or skin covering with acid mantle. Patients with asteatosis may be accompanied by pruritus. Moisturizers are the first‐line treatment for asteatosis and their adequate use must be recommended. The main purpose of the present guidelines is to define skin symptoms requiring treatment with moisturizers for medical use in patients with asteatosis. If the deterioration of marked scaling or scratch marks is predicted, therapeutic intervention with moisturizers for medical use should be considered even in the absence of pruritus. Regarding six important points requiring decision‐making in clinical practice (clinical questions), we evaluated the balance between the benefits and harm of medical interventions in reference to previous reports of clinical research, and presented the recommendation grades and evidence levels to optimize the patient outcome by medical interventions.

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“…[1][2][3][4][5][6][7][8][9][10][11] In severe cases, topical steroids and antihistamines may be needed in addition to moisturisers. 12 Recognition of the physiological changes to the skin caused by ageing has gained importance in recent years due to an increasing population of older individuals. To the best of our knowledge, no study has measured the knowledge level of older people regarding skin dryness and the use of moisturisers.…”

Section: Introductionmentioning

confidence: 99%

“…Regular skin moisturising is very useful for delaying skin ageing and is also the most important step in the treatment of xerosis 1‐11 . In severe cases, topical steroids and antihistamines may be needed in addition to moisturisers 12 . Recognition of the physiological changes to the skin caused by ageing has gained importance in recent years due to an increasing population of older individuals.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of awareness regarding skin moisturisation and moisturiser usage frequency in individuals over 65 years of age

2020

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Objective: Skin dryness is a common dermatological problem among older people. We aimed to evaluate the frequency of moisturiser use and awareness of its benefits among older people. Methods: This cross-sectional descriptive study included 556 individuals over 65 years of age, all of whom were patients at family medicine and dermatology outpatient clinics at a tertiary teaching hospital. Data were summarised descriptively and analysed using binary logistic regression analysis. Results: Of the 556 individuals who participated in the study, 241 were women and 315 were men. Moisturisers were being used by 217 patients (39%), and 91 patients (16.4%) classified the use of skin moisturisers as skincare. Conclusion: We found that individuals over 65 years of age had insufficient knowledge regarding the use and benefits of skin moisturisers.

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Efficacy of anti‐inflammatory moisturizer vs hydrophilic cream in elderly patients with moderate to severe xerosis: A split site, triple‐blinded, randomized, controlled trial

Cited by 5 publications

References 23 publications

Stability Profile and Clinical Evaluation of an Innovative Hydrogel Containing Polymeric Micelles as Drug Delivery Systems with Oregano Essential Oil against Fibroepithelial Polyps

Stability Profile and Clinical Evaluation of an Innovative Hydrogel Containing Polymeric Micelles as Drug Delivery Systems with Oregano Essential Oil against Fibroepithelial Polyps

English version of guidelines for the management of asteatosis 2021 in Japan

Evaluation of awareness regarding skin moisturisation and moisturiser usage frequency in individuals over 65 years of age

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