Efficacy of antiseptic-impregnated catheters on catheter colonization and catheter-related bloodstream infections in patients in an intensive care unit

Osma, Selcan; Kahveci, Ferda; Kaya, F. N.; Akalın, Halis; Özakın, Cüneyt; Yılmaz, Emel; Kutlay, Oya

doi:10.1016/j.jhin.2005.06.030

Cited by 46 publications

(28 citation statements)

References 26 publications

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“…Antiseptic catheters showed a substantial decrease in bacterial colonisation compared with standard uncoated triple lumen catheters; however, this study was unable to show a significant decrease in CRBSI, possibly because of the low infection rate due to fastidious aseptic technique used during catheter insertion (Rupp et al 2005). In contrast, Osma et al (2006) found that central venous catheters impregnated with chlorhexidine and silver sulfadiazine had no effect on the incidence of CRBSI or catheter colonisation in critically ill patients.…”

Section: Antimicrobial Biomaterialsmentioning

confidence: 56%

Staphylococcus epidermidis device-related infections: pathogenesis and clinical management

McCann

Gilmore

Gorman

2008

Journal of Pharmacy and Pharmacology

159

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Staphylococcus epidermidis, the most frequently isolated coagulase‐negative staphylococcus, is the leading cause of infection related to implanted medical devices (IMDs). This is directly related to its capability to establish multilayered, highly structured biofilms on artificial surfaces. At present, conventional systemic therapies using standard antimicrobial agents represent the main strategy to treat and prevent medical device‐associated infections. However, device‐related infections are notoriously difficult to treat and bacteria within biofilm communities on the surface of IMDs frequently outlive treatment, and removal of the medical device is often required for successful therapy. Importantly, major advances in this research area have been made, leading to a greater understanding of the complexities of biofilm formation of S. epidermidis and resulting in significant developments in the treatment and prevention of infections related to this member of the coagulase‐negative group of staphylococci. This review will examine the pathogenesis of the clinically significant S. epidermidis and provide an overview of the conventional and emerging antibiofilm approaches in the management of medical device‐associated infections related to this important nosocomial pathogen.

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Section: Antimicrobial Biomaterialsmentioning

confidence: 56%

Staphylococcus epidermidis device-related infections: pathogenesis and clinical management

McCann

Gilmore

Gorman

2008

Journal of Pharmacy and Pharmacology

159

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“…One randomized study was analyzed independently, because it was not an interventional sequential study, as were the remaining 6 studies [29].…”

Section: Resultsmentioning

confidence: 99%

“…Turkey [57] 2007 Medical-surgical Adult 241 Turkey [29] 2007 Medical-surgical Adult 133 NOTE. ICU, intensive care unit.…”

mentioning

confidence: 99%

Central Line–Associated Bloodstream Infections in Limited‐Resource Countries: A Review of the Literature

Rosenthal¹

2009

CLIN INFECT DIS

104

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Central line-associated bloodstream infections (CLABSIs) are considered a significant cause of mortality in hospitalized patients; however, the incidence of CLABSIs in limited-resource countries has not been explored analytically. Likewise, the appropriate interventions to prevent, control, and reduce CLABSIs have yet to be analyzed thoroughly. This review demonstrates that the CLABSI rate ranged from 1.6 to 44.6 cases per 1000 central line days in adult and pediatric intensive care units (ICUs) and from 2.6 to 60.0 cases per 1000 central line days in neonatal ICUs and is associated with significant extra mortality, with an odds ratio ranging from 2.8 to 9.5. The results of 6 sequential prospective interventional studies showed that hand hygiene and educational programs were related to a significant reduction in CLABSI rates. CLABSI rates in limited-resource countries are higher than US National Healthcare Safety Network benchmark rates and have a significant impact on mortality. Studies showing successful interventions for a reduction in CLABSIs are few. Subsequently, it can be inferred that additional epidemiological studies need to be conducted to achieve an appreciation of the effects of CLABSIs and to develop more-definitive approaches for CLABSI prevention in the form of practical, low-cost, low-technology measures that are feasible to implement in limited-resource countries.

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“…Management of Candida infection by catheter removal alone is insufficient, because of the high risk of disseminated infections, and treatment of these infections often requires prolonged systemic use of antimicrobial agents [1]. Inhibition of specific and non-specific interactions with microorganisms and release of antimicrobial substances from the bulk or the surface of the medical device are considered the most promising preventive strategies [15][16][17][18][19][20][21]. The design of advanced materials with properties carefully tailored for specific applications can improve the performance of medical devices and reduce the risk of infections [2,22].…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin-functionalized biomaterials loaded with miconazole prevent Candida albicans biofilm formation in vitro

et al. 2010

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Efficacy of antiseptic-impregnated catheters on catheter colonization and catheter-related bloodstream infections in patients in an intensive care unit

Cited by 46 publications

References 26 publications

Staphylococcus epidermidis device-related infections: pathogenesis and clinical management

Staphylococcus epidermidis device-related infections: pathogenesis and clinical management

Central Line–Associated Bloodstream Infections in Limited‐Resource Countries: A Review of the Literature

Cyclodextrin-functionalized biomaterials loaded with miconazole prevent Candida albicans biofilm formation in vitro

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