Efficacy of autologous serum in fixing conjunctival autografts of various sizes in different types and grades of pterygium

Abstract

Purpose: To evaluate the efficacy of autologous serum in fixing conjunctival autografts of various sizes in different grades and types of pterygium and to determine the largest successfully secured graft size. Methods: This prospective interventional study comprised 151 eyes of 151 patients belonging to age group of 21 to 64 years with different grades and types of primary and recurrent pterygium that underwent excision with inferior conjunctivo - limbal autograft secured with autologous serum. The autografts were measured with calipers and were grouped by size into three categories: Group A, small (5 × 5 mm); Group B, medium (5–7 × 5 mm); and Group C, large (>7 × 5 mm). The adhesive fixation power of autologous serum for the various conjunctival autograft sizes was determined for each group using the following criteria: graft stability, cosmetic appearance and complications in the immediate ( first week) and two-months postoperative follow-up visits. Descriptive statistical analysis was used to calculate the percentage frequency of the variables. Results: The groups A, B, and C included 48%, 22%, and 30% of the autografts, respectively. Overall, 93.34% of the grafts were stable with good cosmetic appearance. However, subconjunctival hemorrhage (36%), graft edema (36%) and graft retraction (13.5%) were the most common complications. The largest successfully fixed graft was 14 × 5 mm in size. Conclusion: Autologous serum is efficient in securing conjunctival autografts of various sizes with minimal complications and satisfactory results, including good cosmesis.

Long term evaluation of pterygium excision with conjunctival autografting using autologous blood

“…In our study also there was 1case (2.5%) with early graft retraction, graft size was 7*9mm, which subsided with medical management after 1 week. Thatte S et al 15 has also reported retraction in 9 case (5.96%) where graft size was bigger (>7-5mm) which correlates well with our study.…”

“…Suryavanshi MP et al 16 also reported grafthost junction gap in 7 eyes (20%) which healed completely and epithelialised in 1 month. Thatte S et al 15 had not reported any case of graft-host junction gap in their study of 151 eyes.…”

“…Hemlatha BC et al 12 had also reported zero recurrence rate in 6-30 months of follow-up. Thatte S et al 15 had followed cases for 6 months to 5 yrs. and reported recurrence in3 cases (1.98%) in large and fleshy primary pterygium.…”

Comparison of Sutureless, Glue-Less Conjunctival Autograft Versus Sutured Limbal Conjunctival Autograft for Primary Pterygium

“…Our study revealed the patients age ranged between 22 and 62 years and the maximum number of patients were found to be in the age group of 41-50 years in both the groups. The study by Thatte et al [17] conducted on a total of 151 patients, the age ranged between 21 and 64 years. This study had most patients in the age group of 35-50 years.…”

Autologous Serum for Fixation of Limbal Conjunctival Autograft in Primary Pterygium Surgery

“…13 It has been known that thick grafts not covering the limbus may increase the risk of recurrence. 14 Sabahattin Sul et al, used autologous serum drops in pterygium surgery. They found it better than conventional tears in accelerated corneal epithelial healing following pterygium surgery.…”