Efficacy of Banana Peel in Reduction of Aflatoxin Toxicity in Rats

Abstract

An experiment was conducted to determine the efficiency of banana peel to reduce the toxic effect of aflatoxins (AFS) in male albino rats. Seventy eight male albino rats were assigned to 13 experimental diets. The first one served as control received basal diet only, the second served as control DMSO (basal diet and 5ml DMSO /kg B.W.) daily, but the third and fourth one were received 1mg and 2mg AFs/ml respectively. The three following groups were received basal diet only supplemented with banana peel in percentage of 1,2 and 3%,then three groups received basal diet and orally (1mg AFS suspended in 5ml DMSO /kg B.W.) low dose of aflatoxins with the same levels of banana peel. The last three groups received basal diet and orally (2mg AFS suspended in 5ml DMSO /kg B.W.) high dose of aflatoxins with the same levels of banana peel .The duration of this experiment was 6 weeks. Results showed that, albino rats received 38mg and 76mg/kg aflatoxins revealed a significant elevation in the serum levels of AST, ALT, ALP, creatinine, urea, cholesterol and triglyceride, while decrease in total protein (TP) and albumin. Results of hematological parameters showed decrease in red blood cells (RBCs), hemoglobin (HB), packed cell volume (PCV), mean Corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and mean corpuscular hemoglobin (MCH) and platelets while increase in total leucocyte count (TLC).Body weights and organ weights were determined to study its changes. The treatments with banana peel can play a practical role in detoxification of aflatoxins in albino rats. G3Received orally low dose of AF S (1mg AFS suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday G4 Received orally high dose of AF S (2mg AFS suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday G5 Received basal diet supplemented with banana peel at level 1% G6 Received basal diet supplemented with banana peel at level 2% G7 Received basal diet supplemented with banana peel at level 3% G8 Received orally low dose of AF S (1mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +1% banana peel G9 Received orally low dose of AF S (1mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +2% banana peel G10 Received orally low dose of AF S (1mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +3% banana peel G11 Received orally high dose of AF S (2mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +1% banana peel G12 Received orally high dose of AF S (2mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +2% banana peel G13 Received orally high dose of AF S (2mg AF S suspended in 5ml DMSO/ kg B.W.) twice/ week on Monday and Thursday +3% banana peel

Control of carbendazim toxicity using banana peel powder in rats

“…Also, these results are in harmony with the study of Abdel-Rahman et al . [ 32 ] who found that the banana peel had a practical role in detoxification of aflatoxins in albino rats due to decrease the levels of AST, ALT, ALK-P in the serum.…”

Unveiling the Effects of Fennel (Foeniculum vulgare) Seed Essential Oil as a Diet Supplement on the Biochemical Parameters and Reproductive Function in Female Common Carps (Cyprinus carpio)

“…In the present study, the amount of blood creatinine in the treatments of 200 and 400 mg/kg was not significantly different from the control group, indicating that this level of essence did not negatively affect the kidney and vital organs, but the 600 mg/kg treatment was associated with a notable increase in the creatinine content. Studies by Abdel Rahman et al [48] showed that in the case of aflatoxin poisoning in Oreochromis niloticus, fennel essential oils can significantly lower the level of blood creatinine, which was elevated due to poisoning.…”

In vitro and in vivo assessment of banana peel powder as an aflatoxins biosorbent

“…The concentration of AFs extracted from A. flavus fermentation medium as described by Abdel-Rahman et al (2017) was determined using HPLC technique (Agilent 1200 Series U.S.A with column C 18 , Lichrospher 100 RP-18, 5µm×25cm). The mobile phase constituted of water: methanol: acetonitrile (54:29:17, v/v/v) at flow rate of 1ml/min.…”