Efficacy of Botulinum Toxin A Intradetrusor Injections for Non-neurogenic Urinary Urge Incontinence: A Randomized Double-Blind Controlled Trial

Jabs, Corrine; Carleton, Erica

doi:10.1016/s1701-2163(15)31049-5

Cited by 12 publications

(3 citation statements)

References 19 publications

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“…Only six studies reported on AEs with bladder BTX. 50,114,[139][140][141][142] All six reported on UTIs, with a wide range across studies (17 to 55%) and a summary estimate of 35% (95% CI 29, 43). UTIs were lower among those receiving periurethral bulking (7.5%; 95% CI 3.5, 13; 5 studies) or placebo (6.4%; 95% CI 2.7, 12; 12 studies).…”

Section: Pharmacologic Interventionsmentioning

confidence: 99%

Adverse Events Associated with Nonsurgical Treatments for Urinary Incontinence in Women: a Systematic Review

et al. 2019

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The Brown Evidence-based Practice Center (EPC) conducted this review based on a systematic review of the scientific literature, using established methodologies. 8 The PROSPERO registration number is CRD42017069903. The literature search and screening methodology, overall eligibility criteria, strength of evidence, and interpretation of findings are Electronic supplementary material The online version of this article (

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Section: Pharmacologic Interventionsmentioning

confidence: 99%

Adverse Events Associated with Nonsurgical Treatments for Urinary Incontinence in Women: a Systematic Review

et al. 2019

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“…These include botulinum toxin injections for urinary incontinence and transanal irrigation and anterograde continence enema for fecal incontinence. However, these surgical alternatives can be burdensome for the patient, are not always successful and carry their own risks of morbidity (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Needs in Children Suffering From Refractory Non-neurogenic Urinary and Fecal Incontinence and Their Caregivers' Needs and Attitudes Toward Alternative Therapies (SNM, TENS)

et al. 2020

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Background: Non-neurogenic urinary and fecal incontinence (UI, FI) affects approximately 6% of North American children with 1% of cases becoming refractory (nonresponsive to standard therapies). Incontinence has major potential long-term physiological and psychological implications for patients and their families. While Sacral Neuromodulation (SNM) and Transcutaneous Nerve Stimulation (TENS) are alternative therapies available for the treatment of refractory UI/FI, these are not approved for use in children in Canada. The present study assessed participants' perception of current treatments, incontinence burden, and attitudes toward novel therapies in a single pediatric institution. Methods: Multiple validated questionnaires including Dysfunctional Voiding Scoring System (DVSS), Bristol Stool Chart (BSC), Pediatric Incontinence measurement (PinQ), and Time-Driven Activity Based Costing were used to perform a needs assessment for patients with non-neurogenic refractory incontinence, and to determine patients' and caregivers' attitudes toward alternative therapies. Results: 75% of patients and 89% of caregivers reported a moderate to severe impact of incontinence on QoL with diminished social interactions among the primary concerns. Caregivers were frustrated with current treatments and were open to trying alternative therapies (SNM and TENS), which, at least in the case of SNM, seems to be less expensive, possibly less burdensome and more effective than current surgical options. Dos Santos et al. Pediatric Incontinence Burden Conclusion: Pediatric refractory UI/FI has a large impact on patients' and caregivers' QoL and alternative therapies with the potential to improve QoL of patients and caregivers should be further investigated as a substitute for surgery.

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“…OnabotulinumtoxinA prevents acetylcholine release at the neuromuscular junction, inducing muscle paralysis [ 13 ]. Although intradetrusor injections of onabotulinumtoxinA are considered to be highly effective in the treatment of OAB, the procedure is invasive and requires performing cystoscopy.…”

Section: Introductionmentioning

confidence: 99%

Can Intradetrusor OnabotulinumtoxinA Injections Alter Heart Function in Patients with Cardiac Arrhythmia?

Miotła

Olejniczak

Futyma

et al. 2018

JCM

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The prevalence of overactive bladder (OAB) increases with age and can be associated with other co-morbidities, such as cardiac arrhythmia. Unfortunately, commonly used anticholinergic drugs for OAB can affect the cardiovascular system, leading to tachycardia. However, there are no data, which consider the influence of intradetrusor onabotulinumtoxinA injections on heart function in idiopathic OAB patients. The aim of the present study was to evaluate the influence of intradetrusor onabotulinumtoxinA injections on electrocardiogram (ECG) parameters. Additionally, changes in ECG were analyzed in OAB patients without cardiac arrhythmia. Thirty-one patients with cardiac arrhythmia and 31 participants without irregular heart rate (HR) completed the study. ECG measurements were performed in supine positions 2 h before onabotulinumtoxinA injections, 1 h after treatment, and at 2 weeks of follow-up. At week 6, a phone-call survey was conducted to collect data about adverse events. OnabotulinumtoxinA injections were performed with rigid cystoscopy under local anesthesia. We did not observe any clinically significant changes in the analyzed ECG parameters between consecutive measurements. While a slight increase of HR was observed in patients without cardiac arrhythmia, it remained within normal range. Intravesical onabotulinumtoxinA injections are, hence, safe for female patients with cardiac arrhythmia and do not significantly influence changes in ECG.

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Efficacy of Botulinum Toxin A Intradetrusor Injections for Non-neurogenic Urinary Urge Incontinence: A Randomized Double-Blind Controlled Trial

Cited by 12 publications

References 19 publications

Adverse Events Associated with Nonsurgical Treatments for Urinary Incontinence in Women: a Systematic Review

Adverse Events Associated with Nonsurgical Treatments for Urinary Incontinence in Women: a Systematic Review

Assessment of Needs in Children Suffering From Refractory Non-neurogenic Urinary and Fecal Incontinence and Their Caregivers' Needs and Attitudes Toward Alternative Therapies (SNM, TENS)

Can Intradetrusor OnabotulinumtoxinA Injections Alter Heart Function in Patients with Cardiac Arrhythmia?

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