Efficacy of caffeic acid in preventing nickel induced oxidative damage in liver of rats

Ameliorative Effects of Caffeic Acid on Lead Accumulation and Oxidative Stress in Lead-Exposed Mice

“…Allicin was markedly effective in decreasing lead-induced lipid peroxidation and increasing the cellular antioxidant enzyme activities and GSH levels [31]. Despite known property of CA as an antioxidant [7,8], its administration in the present work had no significant effect on increased values of MDA in erythrocyte haemolysate of mice in group 3 as compared to lead-exposed animals in group 2. Despite the present findings, Psotova et al [32] reported that CA was able to decrease the augmented levels of lipid peroxidation and to eliminate intracellular GSH decline of hepatocytes intoxicated by Fe (III), Cu (II) and tertbutyl hydroperoxide.…”

“…CA ability in forming complexes with some metal ions has been reported previously, the effect which is favored by the presence of two hydroxyl groups attached to its main ring that may produce a site for chelation [8,9]. Up to authors' knowledge, CA has not been used as a possible therapeutic approach for lead poisoning.…”

“…Up to authors' knowledge, CA has not been used as a possible therapeutic approach for lead poisoning. However, it has been proposed that protective mechanism exerted by CA towards nickel toxicity may be due to its ability to chelate the nickel from liver by forming complexes with metal favoring its elimination [8].…”

“…CA acts as a free-radical scavenger by virtue of its hydrogen-donating ability, forming aryloxyl radicals and stabilization of such radicals by other functional groups in the structure, thus enhancing antioxidant activity [7,8]. It has been reported that administration of CA protects the liver from nickel induced oxidative damage by decreasing the liver marker enzymes, lipid peroxidative markers and by increasing antioxidant cascade [8]. Moreover, beneficial effect of CA on the improvement of chromium induced oxidative stress in rat intestine has been documented [9].…”

Nephrotoxicity of nickel nanoparticles in rat: Effect of different doses

“…The major target organs for Ni compounds include liver, kidney, brain, lung and testes [10]. .Ni was found to cause neurotoxicity, hepatotoxicity, nephrotoxicity, gene toxicity, reproductive toxicity [11]- [12]- [13]- [14].…”