Efficacy of cancer vaccines in selected gynaecological breast and ovarian cancers: A 20-year systematic review and meta-analysis

Dafni, Urania; Lluesma, Silvia Martin; Balint, Klara; Tsourti, Zoi; Vervita, Katerina; Chenal, J.; Coukos, George; Zaman, Khalil; Sarivalasis, Apostolos; Kandalaft, Lana E.

doi:10.1016/j.ejca.2020.10.014

Cited by 25 publications

(36 citation statements)

References 111 publications

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“…In this regard, BC represents the third most studied tumour for cancer vaccination, following melanoma and cervical cancer [ 23 ]. Historically, the most common TAAs targeted in BC are HER2, Mucin 1, cell surface associated (MUC-1), carcinoembryonic antigen (CEA) and human telomerase reverse transcriptase (hTERT) [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic vaccines for breast cancer: Has the time finally come?

Corti

Giachetti

Eggermont

et al. 2022

European Journal of Cancer

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Section: Introductionmentioning

confidence: 99%

Therapeutic vaccines for breast cancer: Has the time finally come?

Corti

Giachetti

Eggermont

et al. 2022

European Journal of Cancer

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“…[101][102][103] Overall, most trials demonstrated low therapeutic effects with a median PFS of 13.0 months, mainly due to the low expression of the target antigen, tumor heterogeneity, and the patient population. 100,104 A prolongation of PFS and OS in recurrent EOC was demonstrated in several clinical trials investigating the efficacy of NY-ESO-1-based vaccines, 105,106 dendritic cell (DC) vaccines based on a pool of peptides (Her2/neu, hTERT, and PADRE peptides), 107 or whole-tumor vaccines of autologous tumor cells infected with Newcastle disease virus, 108 or viral oncolysate vaccine generated from EOC cell lines infected with influenza-A virus. 109 DC vaccination with whole-tumor lysate might be a relevant strategy for EOC treatment, as surgery is a crucial component of EOC treatment, and therefore sufficient tumoral material should be available (Figure 1).…”

Section: Dendritic-cell Vaccinationmentioning

confidence: 99%

Cell therapies in ovarian cancer

et al. 2021

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Epithelial ovarian cancer (EOC) is the most important cause of gynecological cancer-related mortality. Despite improvements in medical therapies, particularly with the incorporation of drugs targeting homologous recombination deficiency, EOC survival rates remain low. Adoptive cell therapy (ACT) is a personalized form of immunotherapy in which autologous lymphocytes are expanded, manipulated ex vivo, and re-infused into patients to mediate cancer rejection. This highly promising novel approach with curative potential encompasses multiple strategies, including the adoptive transfer of tumor-infiltrating lymphocytes, natural killer cells, or engineered immune components such as chimeric antigen receptor (CAR) constructs and engineered T-cell receptors. Technical advances in genomics and immuno-engineering have made possible neoantigen-based ACT strategies, as well as CAR-T cells with increased cell persistence and intratumoral trafficking, which have the potential to broaden the opportunity for patients with EOC. Furthermore, dendritic cell-based immunotherapies have been tested in patients with EOC with modest but encouraging results, while the combination of DC-based vaccination as a priming modality for other cancer therapies has shown encouraging results. In this manuscript, we provide a clinically oriented historical overview of various forms of cell therapies for the treatment of EOC, with an emphasis on T-cell therapy.

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“…Currently, the incidence of OC is increasing worldwide with the affected population getting younger. In 2018, globally, there were more than 290,000 new cases and approximately 185,000 OC-related deaths (4,5). At present, the main treatment methods include radical OC surgery, cytoreductive surgery, and platinum combined with paclitaxel chemotherapy; however, the 5-year survival rate remains poor (6).…”

Section: Introductionmentioning

confidence: 99%

Plasma exosome-derived fragile-site associated tumor suppressor is a powerful predictor of prognosis in patients with ovarian cancer

Chen

Zhang

et al. 2021

Bosn J of Basic Med Sci

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Objective: To investigate the levels of plasma exosome-derived fragile-site associated tumor suppressor (FATS) and evaluate its predictive ability in ovarian cancer (OC) patients. Patients and Methods: Exosome-rich fractions were isolated from the plasma of enrolled 90 patients with OC. The levels of plasma exosome-derived FATS were detected with ELISA. Results: The levels of exosome-derived FATS in OC patient were significantly lower than in healthy controls (P < 0.001). The levels of plasma exosome-derived FATS were obviously higher in OC patients with low grade (1/2), FIGO stages I/II than high grade (3/4), stages III/ IV disease (P = 0.003; P < 0.001). The levels of plasma exosome-derived FATS were significantly higher in OC patients with no lymph node metastasis, no ascites than those with lymph node metastasis, ascites (both P < 0.001). The levels of plasma exosome-derived FATS were obviously higher in OC patients with CA-125 less than 35U/ml than more than 35U/ml (P < 0.001). Among all enrolled OC patients, both 5-DFS and 5-OS were shorter in patients who had low plasma exosome-derived FATS levels than that high levels (both P < 0.001). The AUROC of plasma exosome-derived FATS were 0.85(95% CI: 0.76-0.91) for 5-DFS, 0.91(95% CI: 0.83-0.96) for 5-OS prediction in patients with OC, respectively. Conclusions: Plasma exosome-derived FATS levels in OC patient were significantly down-regulated. Low levels of plasma exosome-derived FATS had close relationship with FIGO stages I/II, low grade, ascites, higher levels of CA-125, lymph node metastasis and prognosis of OC patients. Our findings may provide a new strategy in treating OC.

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Efficacy of cancer vaccines in selected gynaecological breast and ovarian cancers: A 20-year systematic review and meta-analysis

Cited by 25 publications

References 111 publications

Therapeutic vaccines for breast cancer: Has the time finally come?

Therapeutic vaccines for breast cancer: Has the time finally come?

Cell therapies in ovarian cancer

Plasma exosome-derived fragile-site associated tumor suppressor is a powerful predictor of prognosis in patients with ovarian cancer

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