Efficacy of chloroquine in the treatment of malaria in children under five years in Baissa (Gongola State, Nigeria)

Daniel, H.; Molta, N. B.

doi:10.1080/00034983.1989.11812353

Cited by 10 publications

(6 citation statements)

References 14 publications

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“…The present work has shown the effectiveness of a scheme using a single dose of chloroquine, comparable to the classical schemes. Similar results have been obtained in Asia and Africa 6,7 .…”

Section: Discussionsupporting

confidence: 88%

“…There is a possibility that, within a mean period of 20 days after beginning treatment, the patients present a limited parasitological recrudescence per si, without a manifest clinical picture. This phenomenon has been demonstrated byDANIEL & MOLTA (1989). They used a single dose of chloroquine in the treatment of 53 children, in which the failure of schizonticide action of chloroquine was demonstrated and this was not associated with clinical disease7 .…”

mentioning

confidence: 94%

“…This phenomenon has been demonstrated byDANIEL & MOLTA (1989). They used a single dose of chloroquine in the treatment of 53 children, in which the failure of schizonticide action of chloroquine was demonstrated and this was not associated with clinical disease7 .…”

mentioning

confidence: 94%

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Assessment of chloroquine single dose treatment of malaria due to Plasmodium vivax in Brazilian Amazon

Pinto

Azevedo²,

Silva³

et al. 2003

Rev. Inst. Med. trop. S. Paulo

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Malaria regions of the Amazon basin have been characterized by difficult access and non-compliance of the patients to treatment. In an attempt to assess the schizonticide efficacy of chloroquine in a single dose of 600 mg, the authors realized a double-blind, placebo-controlled trial in 132 outpatients with vivax malaria. Patients were distributed into two groups: group CPLA, given chloroquine 600 mg (single dose) on the first day of treatment, and two doses of placebo on second and third days. Group CHLO, given chloroquine 600 mg on first day and 450 mg on second and third day. Geometric means of the parasite density during the follow-up was similar in both groups. No differences were observed in the parasitological cure between the two groups (p = 0.442). There was clinical and parasitological efficacy in treatment of patients given a single-dose of chloroquine. This suggests that its restricted use could be indicated in remote areas of Brazilian Amazon Region, nevertheless the inadequate response of three patients indicates the need for further studies.

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Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 94%

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Assessment of chloroquine single dose treatment of malaria due to Plasmodium vivax in Brazilian Amazon

Pinto

Azevedo²,

Silva³

et al. 2003

Rev. Inst. Med. trop. S. Paulo

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“…Malaria is a disease of immense public importance. Available data suggest that there are 200-300 million cases, with more than two million deaths each year (Krogtad et al, 1990) out of which one million is from the African continent alone (Daniel and Molta, 1989). Chloroquine, a 4-aminoquinolone, has been the mainstay of malaria chemotherapy for almost 50 years now.…”

Section: Introductionmentioning

confidence: 99%

“…This is because of its rapid onset of action, low toxicity and, almost low expense. It has remained the cheapest and most widely used antimalarial drug in West Africa (Adubofour, 1992) and in Nigeria (Daniel and Molta, 1989). A WHO scientifc group has drawn the attention of the emergence of chloroquine-resistant Plasmodium falciparum in Sub -saharan Africa (WHO 1994).…”

Section: Introductionmentioning

confidence: 99%