Efficacy of Collagen Particles in Chronic Non Healing Ulcers

Chalimidi, Karunakar Reddy; Kumar, Yogesh; Kini, UllalAnand

doi:10.7860/jcdr/2015/11782.6001

Cited by 9 publications

(12 citation statements)

References 12 publications

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“…10 Chalimidi et al noted that dressing with collagen particles was effective in early healing of chronic ulcer by formation of early granulation tissue and also by wound contraction. 11 There was difference of 13.20% of healing ulcer in the test group when compared to controls. 33.30% of the patients in test group had healed ulcer at 8 th week follow up whereas it was 20% in control group who received saline dressings.…”

Section: Discussionmentioning

confidence: 78%

Clinical study of sterile collagen (Biofil) particles in the management of chronic non healing ulcers and their comparison with saline dressings

et al. 2020

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Background: Chronic non healing ulcers are a challenge to the patient and health care professional. They require special care and intensive treatment often for prolonged periods. These ulcers do not generally heal with conventional types of treatment within a reasonable time period and need special types of treatment like collagen particles, vacuum dressing, chemical debridement etc. The aim of the study was to compare the effect of sterile collagen particles with saline dressings in treatment of chronic non healing ulcers.Methods: 30 test subjects were dressed using sterile collagen particles and 30 controls using saline gauze on day 2 and every 3rd day. The condition of the ulcer was followed up using the Bates-Jensen wound assessment score (BJWA score).Results: BJWA score was significantly lesser at 4th week in test group. The p value was 0.00021. Test group mean score was 17.23 and for control group it was 21.467. BJWA score was significantly lesser even at 8th week in Test group. The p value was 0.00026. Test group mean score was 12.47 and control group it was 17.43. This signifies that healing rate is better in test group compared to control group.Conclusions: Comparing the components in BJWA score we can conclude from our study that; collagen dressings are superior to saline dressing in all type of ulcers and irrespective of gender and age of a person. The best response was seen in non diabetic ulcer without Saphenofemoral incompetence who are non smokers.

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Section: Discussionmentioning

confidence: 78%

Clinical study of sterile collagen (Biofil) particles in the management of chronic non healing ulcers and their comparison with saline dressings

et al. 2020

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“…2 Ulcer healing was assessed by measuring reduction in size, epithelialization at margins, appearance of granulation tissue at floor. 6,9,10 Study by Quillien and Goel et al favour similar results. 11,12 Appearance of red granulation tissue and clearance of slough were taken as a sign of healing and time was recorded for comparison.…”

Section: Excluded Criteriamentioning

confidence: 75%

“…6 After debridement nano collagen particles application adhere to ulcer floor, reduces plasma oozing, bacterial colonization and pain, thus boost the process of epithelialization and early ulcer healing. 2,5,7,9,10,13,14 Most common pathogen isolated from ulcer discharge was staphylococcus aureus followed by Klebsiella, Pseudomonas, Proteus, Streptococcus and E. coli in decreasing order, in 13% culture found sterile. 73% patients complained of itching and burning sensation at ulcer site after collagen application.…”

Section: Discussionmentioning

confidence: 99%

Role of nano-collagen particles dressing in the management of chronic ulcer: a prospective non-randomized trial on 100 cases

Kochar

Singh

2020

Int Surg J

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Background: Collagen has unique property of adhere to the ulcer floor thus reduces plasma oozing, bacterial colonization, pain and ulcer size which boost the process of granulation and epithelialization thus healing.Methods: In this prospective, non-randomized study 100 patients of different age and sex having chronic ulcer situated on various parts of the body were taken. Nano collagen particles preparation “collofibre” of TNC health care was used.Results: Most of the patients fall in their most productive life (3rd and 4th decade), restricted mobility due to pain. Thus anaemia, diabetes, old age, debility, bed ridden situations, other associated injuries and certain medical conditions contribute to delay in ulcer healing and hospital stay. Bacterial contamination, presence of necrotic tissue and slough delay the healing process. 73% of patients complain of itching and burning sensation after application otherwise no major side effect detected.Conclusions: Use of nano collagen particles dressing accelerate the healing process in chronic ulcers.

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“…Besides that, it hinders the normal proliferation and migration of fibroblasts to the wound area and eventually slows down the wound healing [ 47 ]. Scientifically, it was proven that collagen accelerates wound healing and enhances re-epithelisation [ 48 , 49 ]. A study that was conducted by Ulrich and co-workers (2011) [ 43 ] recorded 32 DFU outpatients were successfully managed with oxidised regenerated cellulose (ORC) or collagen matrix.…”

Section: Collagen-based Treatment For Dfumentioning

confidence: 99%

“…These proteins (protease, plasmin, and elastase) distinctively act to degrade the fibronectin, endogenous protease inhibitors, and GF that are the essential elements in the wound healing process. In contrast, the intervention with ORC or collagen matrix at the specified wound region demonstrated an acceleration in ulcer healing on the 28th day as well as providing an optimum microenvironment for wound healing [ 48 ].…”

Section: Collagen-based Treatment For Dfumentioning

confidence: 99%

Cellulose/Collagen Dressings for Diabetic Foot Ulcer: A Review

Naomi

2020

Pharmaceutics

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Diabetic foot ulcer (DFU) is currently a global concern and it requires urgent attention, as the cost allocation by the government for DFU increases every year. This review was performed to provide scientific evidence on the advanced biomaterials that can be utilised as a first-line treatment for DFU patients. Cellulose/collagen dressings have a biological property on non-healing wounds, such as DFU. This review aims to analyse scientific-based evidence of cellulose/collagen dressing for DFU. It has been proven that the healing rate of cellulose/collagen dressing for DFU patients demonstrated a significant improvement in wound closure as compared to current standard or conventional dressings. It has been scientifically proven that cellulose/collagen dressing provides a positive effect on non-healing DFU. There is a high tendency for cellulose/collagen dressing to be used, as it highly promotes angiogenesis with a rapid re-epithelisation rate that has been proven effective in clinical trials.

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Efficacy of Collagen Particles in Chronic Non Healing Ulcers

Cited by 9 publications

References 12 publications

Clinical study of sterile collagen (Biofil) particles in the management of chronic non healing ulcers and their comparison with saline dressings

Clinical study of sterile collagen (Biofil) particles in the management of chronic non healing ulcers and their comparison with saline dressings

Role of nano-collagen particles dressing in the management of chronic ulcer: a prospective non-randomized trial on 100 cases

Cellulose/Collagen Dressings for Diabetic Foot Ulcer: A Review

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