Efficacy of Constraint-Induced Movement Therapy in Early Stroke Rehabilitation

Thrane, Gyrd; Askim, Torunn; Stock, Roland; Indredavik, Bent; Gjone, Ragna Ingeborg; Erichsen, Anne Spendrup; Anke, Audny

doi:10.1177/1545968314558599

Cited by 40 publications

(51 citation statements)

References 31 publications

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“…Our result was consistent with a randomized controlled trial, which did not find a favorable effect of CIMT during the 6-month follow-up (Thrane et al, 2015). Recently, a home-based CIMT in patients with upper limb dysfunction after stroke showed that patients in both the groups showed improvement in the QOM.…”

Section: Discussionsupporting

confidence: 93%

“…The exclusion criteria were: (1) inability to provide informed consent; (2) a history of stroke; (3) deviation greater than 2 cm on the line bisection test; (4) morbidity of the affected upper extremity resulting in functional limitation prior to stroke; (5) life expectancy less than 1 year; or (6) other neurological conditions affecting motor function or assessment (Thrane et al, 2015). Following informed consent, the patients were assigned to mCIMT or the control group using random odd- and even-numbered tickets in sealed envelopes.…”

Section: Methodsmentioning

confidence: 99%

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The Effects of Modified Constraint-Induced Movement Therapy in Acute Subcortical Cerebral Infarction

Wang

Yue

et al. 2017

Front. Hum. Neurosci.

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Background: Constraint-induced movement therapy (CIMT) promotes upper extremity recovery post stroke, however, it is difficult to implement clinically due to its high resource demand and safety of the restraint. Therefore, we propose that modified CIMT (mCIMT) be used to treat individuals with acute subcortical infarction.Objective: To evaluate the therapeutic effects of mCIMT in patients with acute subcortical infarction, and investigate the possible mechanisms underlying the effect.Methods: The role of mCIMT was investigated in 26 individuals experiencing subcortical infarction in the preceding 14 days. Patients were randomly assigned to either mCIMT or standard therapy. mCIMT group was treated daily for 3 h over 10 consecutive working days, using a mitt on the unaffected arm for up to 30% of waking hours. The control group was treated with an equal dose of occupational therapy and physical therapy. During the 3-month follow-up, the motor functions of the affected limb were assessed by the Wolf Motor Function Test (WMFT) and Motor Activity Log (MAL). Altered cortical excitability was assessed via transcranial magnetic stimulation (TMS).Results: Treatment significantly improved the movement in the mCIMT group compared with the control group. The mean WMF score was significantly higher in the mCIMT group compared with the control group. Further, the appearance of motor-evoked potentials (MEPs) were significantly higher in the mCIMT group compared with the baseline data. A significant change in ipsilesional silent period (SP) occurred in the mCIMT group compared with the control group. However, we found no difference between two groups in motor function or electrophysiological parameters after 3 months of follow-up.Conclusions: mCIMT resulted in significant functional changes in timed movement immediately following treatment in patients with acute subcortical infarction. Further, early mCIMT improved ipsilesional cortical excitability. However, no long-term effects were seen.

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

The Effects of Modified Constraint-Induced Movement Therapy in Acute Subcortical Cerebral Infarction

Wang

Yue

et al. 2017

Front. Hum. Neurosci.

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“…However, the attrition rate at the primary end-point of outcome (end of the 6-week intervention phase) was only 11%, and the attrition rate at both time points was comparable to other randomised controlled trials in stroke rehabilitation [31].…”

Section: Of 25supporting

confidence: 72%

Functional strength training and movement performance therapy produce analogous improvement in sit-to-stand early after stroke: early-phase randomised controlled trial

et al. 2017

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“…Rehabilitation techniques rely on the idea that learning mechanisms remain preserved and will support re-learning. This may be most obvious when applied to motor learning and constraint therapy (Thrane et al, 2015), but it is also clearly required for many occupational and cognitive therapies. Therapy frequently presumes that with practice, the effective actions will come to be the predominant actions.…”

Section: Discussionmentioning

confidence: 99%

Statistical Learning Impairments as a Consequence of Stroke

Shaqiri

Danckert

Burnett

et al. 2018

Front. Hum. Neurosci.

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Statistical learning is the implicit learning of the contingencies between sequential stimuli, typically from mere exposure. It is present from infancy onward, and plays a role in functions from language learning to selective attention. Despite these observations, there are few data on whether statistical learning capacity changes with age or after brain injury. In order to examine how brain injury affects the ability to learn and update statistical representations, we had young control and healthy elder participants, as well as participants with either left or right brain injury, perform an auditory statistical learning task. Participants listened to two languages with made-up words that were defined by the transition probability between syllables. Following passive listening, learning was assessed with a two-alternative forced choice test for the most familiar word. As in previous studies, we found that young controls have a learning capacity limitation for statistical learning; a second language is less well learned than the first, and this statistical learning capacity limit is attenuated with age. Additionally, we found that brain damaged patients, whether with left or right hemispheric damage, showed impaired statistical learning. This impairment was not explained by aphasia or cognitive deficits. As statistical learning is a critical skill for daily life, a better appreciation of the nature of this impairment will improve our understanding of the cognitive effects of brain injury and could lead to new rehabilitation strategies.

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Efficacy of Constraint-Induced Movement Therapy in Early Stroke Rehabilitation

Abstract: Despite a favorable effect of CIMT on timed movement measures immediately after treatment, significant effects were not found after 6 months.

Cited by 40 publications

References 31 publications

The Effects of Modified Constraint-Induced Movement Therapy in Acute Subcortical Cerebral Infarction

The Effects of Modified Constraint-Induced Movement Therapy in Acute Subcortical Cerebral Infarction

Functional strength training and movement performance therapy produce analogous improvement in sit-to-stand early after stroke: early-phase randomised controlled trial

Statistical Learning Impairments as a Consequence of Stroke

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