Efficacy of Curcumin and Monochromatic Light in Improving Liver Functions of Sexually Mature Magelang Ducks

Abstract

Hati unggas betina memiliki peran vital sebagai tempat biosintesis prekursor kuning telur, karena perannya ini hati mudah mengalami kerusakan seluler. Tujuan penelitian ini ialah mengkaji efikasi suplementasi kurkumin dan penggunaan cahaya monokromatik dalam menekan histopatologi hati pada biosintesis kuning telur itik lokal. Pada penelitian ini digunakan seratus sembilan puluh dua ekor itik magelang betina. Rancangan penelitian yang digunakan ialah rancangan acak lengkap dengan susunan faktorial 4x4. Faktor pertama berupa dosis kurkumin, yaitu 0, 9, 18, dan 36 mg/ekor/hari. Faktor kedua adalah warna cahaya yang terdiri atas putih, merah, hijau, dan biru. Hasil penelitian menunjukkan bahwa degenerasi hidropik dan perlemakan pada hepatosit masih dalam kategori normal. Terdapat interaksi antara dosis kurkumin dan warna cahaya monokromatik yang menyebabkan penurunan konsentrasi serum glutamic-piruvic transaminase/glutamic-oxaloacetic transaminase (SGPT/GOT) dan malondyaldehid (MDA) hati (P<0,05), secara berurutan menurun hingga 24,63%, 24,75% dan 22,5%. Peningkatan kadar trigliserida dan kolesterol berkorelasi positif dengan peningkatan SGPT/GOT serum dan MDA hati. Suplementasi kurkumin dan penambahan cahaya monokromatik dapat menghambat kerusakan oksidatif hati itik yang sedang mensintesis kuning telur sehingga kondisi patologis dapat ditekan.

Impact of curcumin supplementation in monochromatic light on lipid serum profile of sexually mature female Magelang ducks

“…The plasma lipid concentration increased from 3 mg ml -1 in un-laying turkeys to 21 mg ml -1 during laying period (Bacon et al, 1974). Our previous study also found the increased serum vitellogenin (Kasiyati et al, 2016a) and fat droplet in hepatocytes vacuoles of magelang ducks supplemented with curcumin in exposed to white, red, green, or blue light (Kasiyati et al, 2016b).…”

“…Optimized lipids catabolism increase substrate supply for the biosynthesis of yolk egg precursors. Curcumin supplementation of sexually mature female magelang ducks was closely related with the role of curcumin as hepatoprotector (Kasiyati et al, 2016b), supported by the use of monochromatic light can stimulate secretion of lipolytic hormones so the lipids were (Ke et al, 2011), so that biosynthesis of the egg yolk component in the liver cells more optimal. The liver of laying birds during sexual maturity have a great capability in converting lipids into the egg yolk component and directly taken by the plasma to be deposited into the growing ovarian follicle oocytes.…”

“…The composition of the materials and nutrient content of the feed was the result of the calculation using Excel program ( Table 1). The formula for feed requirements at each stage of laying duck was prepared referring to previous study (Kasiyati et al, 2016b). The curcumin extract (78.94%) in the form of flour was obtained from Plamed Green Science Ltd, China.…”

Reproductive Performances and Egg Qualities in African Catfish (<i>Clarias gariepinus</i>) Broodstocks Supplemented with Curcumin and Thyroxine Hormone

“…In addition to the presence of estradiol, the physiological state of the liver has a major influence on vitellogenin synthesis (Kasiyati et al, 2016b). However, the supplementation of curcumin not only protects the liver cells but also increases their bioactivities as phytoestrogen that binds to the estradiol receptor and further stimulates the synthesis of vitellogenin (Kasiyati et al, 2016a;Dewi et al, 2018b). Research conducted by Turker and Bozcaarmutlu (2009) showed that feed containing high levels of phytoestrogens could increase vitellogenin production in carp.…”

The Role of Turmeric Powder Supplementation in Improving Liver Performances to Support Production of Siam Catfish (Pangasianodon hypophthalmus)

“…Saraswati et al (2013) showed that the increase in turmeric powder supplementation up to 54 mg/quail/day showed the optimal results in improving the physiological conditions of quails. The bioactive Component of curcumin is very important as a hepatoprotector to protect hepatocytes from destruction caused by the free radicals, as was indicated by the decrease in the serum SGPT and SGOT concentrations in the ducks supplemented with curcumin (Kasiyati et al 2016). Figure 1.…”